List of autoimmune diseases

Last updated

This article provides a list of autoimmune diseases . These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed with the condition. Each disorder is also categorized by its acceptance as an autoimmune condition into four levels: confirmed, probable, possible, and uncertain. This classification is based on the current scientific consensus and reflects the level of evidence supporting the autoimmune nature of the disorder. Lastly, the prevalence rate, specifically in the United States, is included to give a sense of how common each disorder is within the population.

Contents

Integumentary system

The integumentary system, composed of the skin, hair, nails, and associated glands, serves as a protective barrier between the body and the environment. It also plays a critical role in regulating body temperature and maintaining fluid balance.

DiseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Alopecia areata Hair follicles None specificConfirmed2.1% [1] [2]
Autoimmune angioedema Skin C1 inhibitor ProbableLess than 5,000 [3]
Autoimmune progesterone dermatitis Skin Progesterone ProbableExtremely rare [4]
Autoimmune urticaria Skin IgG against IgE or IgE receptor ProbableNot well established [5] [6]
Bullous pemphigoid SkinAnti-BP180, Anti-BP230Confirmed6-30 per 100,000 (mostly older adults) [7]
Cicatricial pemphigoid Mucous membranes, sometimes skinAnti-BP180, Anti-BP230ConfirmedRare [8]
Dermatitis herpetiformis SkinAnti-tissue transglutaminase Confirmed10 per 100,000 [9]
Dermatomyositis Skin and muscles Anti-Jo1, Anti-Mi2, Anti-SRP, Anti-TIF1Confirmed9 in 1,000,000 [10]
Discoid lupus erythematosus SkinANA, Anti-dsDNA, Anti-SmConfirmedPart of SLE prevalence (20-150 per 100,000) [11]
Epidermolysis bullosa acquisita SkinAnti-type VII collagenConfirmedExtremely rare [12]
Erythema nodosum SkinNone specificPossibleNot well established [13]
Gestational pemphigoid SkinAnti-BP180, Anti-BP230ConfirmedRare [14]
Hidradenitis suppurativa SkinNone specificUncertain1-4% [15]
Lichen planus Skin, mucous membranesNone specificProbable1% [16]
Lichen sclerosus SkinNone specificProbableRare [17]
Linear IgA disease SkinAnti-epidermal basement membrane IgAConfirmedExtremely rare [18]
Morphea SkinNone specificProbableNot well established [19]
Psoriasis SkinVarious, not specificConfirmed2-3% [20]
Pemphigus vulgaris Skin and mucous membranesAnti-desmoglein 3, Anti-desmoglein 1Confirmed1-5 per 100,000 [21]
Scleroderma (systemic sclerosis)Skin, organsANA, anti-Scl-70, anti-centromereConfirmed240 per 1,000,000 [22]
Vitiligo SkinVarious, not specificConfirmed1% [23]

Digestive system

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Autoimmune enteropathy Small intestine Anti-enterocyte antibodiesProbableRare [24]
Autoimmune hepatitis Liver ANA, ASMA, anti-LKM1Confirmed1 in 10,000 to 1 in 50,000 [25]
Celiac disease Small intestine Anti-tissue transglutaminase antibodies (tTG), Endomysial antibody (EMA), Deamidated gliadin peptide (DGP)Confirmed1 in 100 [26]
Crohn's disease Digestive tractASCA, Anti-OmpC, Anti-CBir1, ANCAProbable201 per 100,000 adults [27]
Pernicious anemia StomachAnti-IF, Anti-parietal cellConfirmed0.1% [28]
Ulcerative colitis Colon and rectumpANCA, ASCAProbable249 per 100,000 adults [29]

Heart and vascular system

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Rheumatic heart disease Heart valves Anti-streptolysin O (ASO), anti-DNase BConfirmedDeclining due to improved treatment of strep throat [30]
Kawasaki disease Coronary arteries UnknownProbable20 per 100,000 children under age 5 [31]
Giant cell arteritis Large and medium arteries, can affect coronary arteriesNone specificConfirmed200 per 100,000 (over age 50) [32] [33]
Takayasu's arteritis Large arteries, including the aorta None specificConfirmedRare, more common in East Asia [33] [34]
Behçet's disease Small to large vessels in mouth, genitals, eyes, skinNone specificProbable [35]
Eosinophilic granulomatosis with polyangiitis (EGPA) Small to medium vessels in respiratory tract, skin, heart, kidneys, nervesANCAConfirmed [36]
Granulomatosis with polyangiitis (GPA) Small to medium vessels in respiratory tract, kidneysc-ANCA/PR3-ANCAConfirmed [36]
IgA vasculitis (IgAV) Small vessels in skin, joints, kidneys, gastrointestinal tractIgA immune complexesProbable [37]
Leukocytoclastic vasculitis Small vessels in skinVarious immune complexesProbable [38]
Lupus vasculitis Small to medium vessels in multiple organsANA, anti-dsDNA, anti-Smith, othersConfirmed [39]
Rheumatoid vasculitis Small to medium vessels in skin, nerves, eyes, heartRheumatoid factor, ACPAProbable [40]
Microscopic polyangiitis (MPA) Small vessels in kidneys, lungs, nerves, skinp-ANCA/MPO-ANCAConfirmed [41]
Polyarteritis nodosa (PAN) Medium to small vessels in kidneys, skin, muscles, joints, nervesNone specificProbable [42]
Polymyalgia rheumatica Large to medium vessels in shoulders, hipsNone specificPossible [43]
Urticarial vasculitis Small vessels in skinC1q antibodiesProbable [44]
Vasculitis All vessel sizes in multiple organsDepends on specific typeUncertain [45]

Urinary system

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Goodpasture syndrome Kidneys, lungs Anti-GBM antibodiesConfirmed1 per million people [46]
IgA nephropathy Kidneys IgA autoantibodiesConfirmed3.5 per 100,000 [47]
Membranous nephropathy Kidneys Anti-PLA2R antibodiesConfirmed10 per 100,000 [48]
Lupus nephritis Kidneys Anti-dsDNA, Anti-Sm, Anti-nuclear antibodiesConfirmedUp to 60% of those with Lupus [49]
Interstitial nephritis Kidneys Various autoantibodiesProbableVaries widely, often drug-induced [50]
Interstitial cystitis Bladder Anti-urothelial and anti-nuclear antibodiesProbable100-450 per 100,000 women, less common in men [51]
Primary sclerosing cholangitis Bile ducts, can affect gallbladder P-ANCA, Anti Smooth Muscle Antibodies (ASMA)Confirmed1 per 100,000 [52]

Nervous system

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Acute disseminated encephalomyelitis Central nervous system UnknownConfirmed0.8 per 100,000 [53]
Acute motor axonal neuropathy Peripheral nerves Anti-GM1 ConfirmedPart of Guillain-Barré syndrome prevalence [54]
Anti-NMDA receptor encephalitis Brain Anti-NMDA receptor Confirmed1.5 per million [55]
Autoimmune encephalitis BrainVarious, depending on subtype (e.g., NMDA receptor antibodies, LGI1 antibodies)ConfirmedRare [56]
Balo concentric sclerosis Central nervous systemUnknownProbableRare [57]
Bickerstaff's encephalitis BrainAnti-GQ1bConfirmedRare [58]
Chronic inflammatory demyelinating polyneuropathy Peripheral nervesVarious, including anti-MAGConfirmed1-2 per 100,000 [59]
Guillain-Barré syndrome Peripheral nervesVarious, including anti-GM1, anti-GD1aConfirmed1-2 per 100,000 [60]
Hashimoto's encephalopathy BrainAnti-thyroid (TPO, Tg)ProbableRare [61]
Idiopathic inflammatory demyelinating diseases Central nervous systemVariesProbableVaries by specific disease [62]
Lambert–Eaton myasthenic syndrome Neuromuscular junction (affecting both CNS and PNS)Anti-VGCCConfirmed0.5-2 per million [63]
Multiple sclerosis Central nervous systemUnknown, but Oligoclonal bands often present in CSFConfirmed90 per 100,000 [64]
Myasthenia gravis Neuromuscular junction (affecting both CNS and PNS)Anti-AChR, anti-MuSKConfirmed20 per 100,000 [65]
Neuromyelitis optica (Devic's disease)/NMOSD Optic nerves and spinal cordAQP4-IgG (NMO-IgG)Confirmed0.5 - 4 per 100,000 [66]
Restless legs syndrome Central nervous system (thought to involve dopaminergic pathways)UnknownUncertain5-15% (more common in older adults) [67]
Stiff-person syndrome Central nervous systemAnti-GAD, anti-amphiphysinConfirmedRare [68]
Sydenham's chorea BrainAnti-basal gangliaConfirmedRare (linked to Group A streptococcal infection) [69]
Transverse myelitis Spinal cordVarious, including anti-AQP4Probable1-8 per million [70]
Undifferentiated connective tissue disease (UCTD) VariousANA (antinuclear autoantibody) (HEp-2 cells)Confirmed2 per 100,000 [71]

Endocrine system

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Addison's disease Adrenal glands 21-hydroxylase antibodiesConfirmed0.93-1.4 per 10,000 [72]
Autoimmune oophoritis Ovaries Anti-ovarian antibodiesProbableRare [73]
Autoimmune orchitis Testes Anti-sperm antibodiesProbableRare [74]
Autoimmune pancreatitis Pancreas IgG4, Anti-CA2 antibodiesConfirmed0.82-1.3 per 100,000 [75]
Autoimmune polyendocrine syndrome type 1 (APS1) Multiple endocrine organsVarious autoantibodies depending on the organs affectedConfirmed1 in 100,000 to 200,000 [76]
Autoimmune polyendocrine syndrome type 2 (APS2) Multiple endocrine organsVarious autoantibodies depending on the organs affectedConfirmed1 in 20,000 [77]
Autoimmune polyendocrine syndrome type 3 (APS3) Multiple endocrine organsVarious autoantibodies depending on the organs affectedConfirmedRare [77]
Diabetes mellitus type 1 Pancreas Anti-insulin, anti-IA-2, anti-GAD, anti-ZnT8 antibodiesConfirmed1.6 per 1,000 [78]
Endometriosis Endometrium Anti-endometrial antibodiesProbable6-10% of women of reproductive age [79]
Graves' disease Thyroid gland TSI, TPO, TG antibodiesConfirmed1.2% of the population [80]
Hashimoto's thyroiditis Thyroid gland TPO, TG antibodiesConfirmed5% of the population [81]
Ord's thyroiditis Thyroid gland TPO, TG antibodiesConfirmedRare [82]
Sjögren syndrome Exocrine glands (salivary and lacrimal glands)Anti-SSA/Ro, Anti-SSB/La antibodiesConfirmed0.1-4% of the population [83]

Respiratory system

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Goodpasture syndrome See urinary system [lower-alpha 1] See urinary system ConfirmedSee urinary system
Eosinophilic granulomatosis with polyangiitis (EGPA) See vascular system [lower-alpha 2] See vascular system ConfirmedSee vascular system
Granulomatosis with polyangiitis (GPA) See vascular system [lower-alpha 3] See vascular system ConfirmedSee vascular system
Idiopathic pulmonary fibrosis LungsNone specificPossible20 per 100,000 (men), 13 per 100,000 (women) [84]
Interstitial lung disease LungsDepends on the subtype (e.g. Anti-Jo1 in Anti-synthetase syndrome)Probable31.5 per 100,000 (men), 26.1 per 100,000 (women) [85]
Pulmonary alveolar proteinosis LungsAnti-GM-CSF antibodiesConfirmed6.2 per million [86]
Rheumatoid lung disease LungsRheumatoid factor, Anti-CCP antibodiesConfirmedPart of RA prevalence (about 1%) [87]
Sarcoidosis Lungs and other organsNone specificConfirmed10 - 40 per 100,000 [88]

Blood

Autoimmune diseaseAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Autoimmune hemolytic anemia Anti-red blood cell antibodiesConfirmed1-3 per 100,000 [89]
Immune thrombocytopenia Anti-platelet antibodiesConfirmed3.3 per 100,000 (adults), 50 per 100,000 (children) [90]
Thrombotic thrombocytopenic purpura ADAMTS13 autoantibodiesConfirmed1-2 per million [91]
Antiphospholipid syndrome Antiphospholipid antibodiesConfirmed40-50 per 100,000 [92]
Paroxysmal nocturnal hemoglobinuria None specific, mutation causes self-cells to become susceptible to attackPossible1-2 per million [93]

Reproductive system

The reproductive system is responsible for the production and regulation of sex hormones, the formation of germ cells, and the nurturing of fertilized eggs. In women, it includes structures such as ovaries, fallopian tubes, a uterus, and a vagina, while in men, it includes testes, vas deferens, seminal vesicles, prostate, and the penis. Autoimmune diseases of the reproductive system can affect both male and female fertility and reproductive health.

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Autoimmune orchitis Testes Anti-sperm antibodiesProbableNot well established [94]
Autoimmune oophoritis Ovaries Anti-ovarian antibodiesProbableNot well established [94]
Endometriosis Uterus, ovaries, and pelvic tissueVarious, including anti-endometrial antibodiesProbableApprox. 10% of women of reproductive age [95]
Premature ovarian failure OvariesAnti-ovarian antibodies, Anti-adrenal antibodiesConfirmed1% of women under 40 years [96]

Eyes

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune diseasePrevalence rate (US)Cit.
Autoimmune retinopathy Retina VariousConfirmed [97]
Autoimmune uveitis Uvea VariousConfirmed [98]
Cogan syndrome Inner ear and eyeNone specificProbable [99]
Graves' ophthalmopathy Eye muscles and connective tissue TSH receptor antibodiesConfirmed [100]
Intermediate uveitis Uvea (pars plana)VariousProbable [101]
Ligneous conjunctivitis Conjunctiva Plasminogen deficiencyPossibleRare [102]
Mooren's ulcer Cornea None specificProbableRare [103]
Neuromyelitis optica Optic nerve and spinal cord Anti-AQP4Confirmed [104]
Opsoclonus myoclonus syndrome Central nervous system, eye movement controlAnti-neuronal antibodiesPossible [105]
Optic neuritis Optic nerveVariousConfirmed [106]
Scleritis Sclera VariousPossible [107]
Susac's syndrome Retina, cochlea, and brainNone specificProbable [108]
Sympathetic ophthalmia Uveal tract VariousProbableRare [109]
Tolosa–Hunt syndrome OrbitNone specificUncertainRare [110]

Muscular system

These autoimmune diseases are primarily associated with the muscles and neuromuscular function.

Autoimmune diseasePrimary organ/body part affectedAutoantibodiesAcceptance as an autoimmune disorderPrevalence rate (US)Cit.
Dermatomyositis See integumentary system [lower-alpha 4] See integumentary system ConfirmedSee integumentary system
Fibromyalgia Musculoskeletal system, pain perceptionNone specificPossible [111]
Inclusion body myositis Proximal and distal musclesNone specificProbable [112]
Myositis Skeletal musclesVarious, depends on subtypeConfirmed [113]
Myasthenia gravis Voluntary muscles, neuromuscular junctionsAnti-acetylcholine receptor, Anti-MuSKConfirmed [114]
Neuromyotonia Peripheral nerves affecting muscle controlAnti-voltage-gated potassium channelsProbable [115]
Paraneoplastic cerebellar degeneration Central nervous system, cerebellumAnti-Yo, Anti-Hu, Anti-Ri, othersConfirmed [116]
Polymyositis Proximal skeletal musclesAnti-Jo-1, Anti-SRP, othersConfirmed [117]

Autoimmune comorbidities

This list includes conditions that are not diseases, but symptoms or syndromes common to autoimmune disease. [118]

Non-autoimmune

At this time, there is not sufficient evidence to indicate that these diseases are caused by autoimmunity.

DiseaseReason not believed to be autoimmuneCit.
Agammaglobulinemia An immune system disorder but not an autoimmune disease.
Amyloidosis No consistent evidence of association with autoimmunity.
Amyotrophic lateral sclerosis No consistent evidence of association with autoimmunity.
Anti-tubular basement membrane nephritis No consistent evidence of association with autoimmunity.
Atopic allergy A hypersensitivity.
Atopic dermatitis A hypersensitivity.
Autism No consistent evidence of association with maternal autoimmunity.
Blau syndrome Overlaps both sarcoidosis and granuloma annulare. No evidence of association with autoimmunity.
Cancer No consistent evidence of association with autoimmunity.
Castleman's disease An immune system disorder but not an autoimmune disease.
Chagas disease No consistent evidence of association with autoimmunity. [121]
Chronic obstructive pulmonary disease No consistent evidence of association with autoimmunity. [122] [123]
Chronic recurrent multifocal osteomyelitis LPIN2, D18S60. Synonyms: Majeed syndrome.
Complement component 2 deficiency Possibly symptomatic of autoimmune diseases, but not a disease.
Congenital heart block May be related to autoimmune activity in the mother.
Contact dermatitis A hypersensitivity.
Cushing's syndrome No consistent evidence of association with autoimmunity.
Cutaneous leukocytoclastic angiitis No consistent evidence of association with autoimmunity.
Dego's disease No consistent evidence of association with autoimmunity.
Eosinophilic gastroenteritis Possibly a hypersensitivity.
Eosinophilic pneumonia A class of diseases, some of which may be autoimmune.
Erythroblastosis fetalis Mother's immune system attacks fetus. An immune system disorder but not autoimmune.
Fibrodysplasia ossificans progressiva Possibly an immune system disorder but not autoimmune.
Gastrointestinal pemphigoid No consistent evidence of association with autoimmunity.
Hypogammaglobulinemia An immune system disorder but not autoimmune.
Idiopathic giant-cell myocarditis No consistent evidence of autoimmune cause though the disease has been found comorbid with other autoimmune diseases. [124]
Idiopathic pulmonary fibrosis Autoantibodies: SFTPA1, SFTPA2, TERT, and TERC.
IgA nephropathy An immune system disorder but not an autoimmune disease.
IPEX syndrome A genetic mutation in FOXP3 that leads to autoimmune diseases, but not an autoimmune disorder itself.
Ligneous conjunctivitis No consistent evidence of association with autoimmunity.
Majeed syndrome No consistent evidence of association with autoimmunity.
Narcolepsy No evidence of association with autoimmunity. Research not reproducible. [125] [126] [127] [128]
Rasmussen's encephalitis No consistent evidence of association with autoimmunity.
Schizophrenia No consistent evidence of association with autoimmunity. [129] [130] [131]
Serum sickness A hypersensitivity.
Spondyloarthropathy No consistent evidence of association with autoimmunity.
Sweet's syndrome No consistent evidence of association with autoimmunity.
Takayasu's arteritis No consistent evidence of association with autoimmunity.
Undifferentiated spondyloarthropathy

See also

Notes

  1. For detailed information on Goodpasture syndrome, including its impact on the respiratory system, refer to its entry in the urinary system section.
  2. For detailed information on EGPA, including its impact on the respiratory system, refer to its entry in the vascular system section.
  3. For detailed information on GPA, including its impact on the respiratory system, refer to its entry in the vascular system section.
  4. For detailed information on dermatomyositis, including its impact on the musclar system, refer to its entry in the integumentary system section.

Related Research Articles

<span class="mw-page-title-main">Sjögren syndrome</span> Autoimmune disease affecting the bodys moisture-producing glands

Sjögren syndrome or Sjögren's syndrome is a long-term autoimmune disease that affects the body's moisture-producing glands, and often seriously affects other organ systems, such as the lungs, kidneys, and nervous system.

<span class="mw-page-title-main">Autoimmunity</span> Immune response against an organisms own healthy cells

In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease resulting from this type of immune response is termed an "autoimmune disease". Prominent examples include celiac disease, diabetes mellitus type 1, Henoch–Schönlein purpura, systemic lupus erythematosus, Sjögren syndrome, eosinophilic granulomatosis with polyangiitis, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis, ankylosing spondylitis, polymyositis, dermatomyositis, and multiple sclerosis. Autoimmune diseases are very often treated with steroids.

<span class="mw-page-title-main">Antinuclear antibody</span> Autoantibody that binds to contents of the cell nucleus

Antinuclear antibodies are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some cases, antibodies to human antigens are produced.

<span class="mw-page-title-main">Hypereosinophilic syndrome</span> Unexplained chronic eosinophila

Hypereosinophilic syndrome is a disease characterized by a persistently elevated eosinophil count in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow.

<span class="mw-page-title-main">Selective immunoglobulin A deficiency</span> Medical condition

Selective immunoglobulin A (IgA) deficiency (SIgAD) is a kind of immunodeficiency, a type of hypogammaglobulinemia. People with this deficiency lack immunoglobulin A (IgA), a type of antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. It is defined as an undetectable serum IgA level in the presence of normal serum levels of IgG and IgM, in persons older than 4 years. It is the most common of the primary antibody deficiencies. Most such persons remain healthy throughout their lives and are never diagnosed.

<span class="mw-page-title-main">Pili torti</span> Medical condition

Pili torti is characterized by short and brittle hairs that appear flattened and twisted when viewed through a microscope.

<span class="mw-page-title-main">Autoimmune disease</span> Disorders of adaptive immune system

An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. It is estimated that there are more than 80 recognized autoimmune diseases, with recent scientific evidence suggesting the existence of potentially more than 100 distinct conditions. Nearly any body part can be involved.

Autoimmune progesterone dermatitis(APD) occurs during the luteal phase of a woman's menstrual cycle and is an uncommon cyclic premenstrual reaction to progesterone. It can present itself in several ways, including eczema, erythema multiforme, urticaria, angioedema, and progesterone-induced anaphylaxis. The first case of autoimmune progesterone dermatitis was identified in 1964. Reproductive function may be impacted by APD.

<span class="mw-page-title-main">Systemic vasculitis</span> Medical condition

Necrotizing vasculitis, also called systemic necrotizing vasculitis, is a general term for the inflammation of veins and arteries that develops into necrosis and narrows the vessels.

<span class="mw-page-title-main">Linear IgA bullous dermatosis</span> Medical condition

Linear IgA bullous dermatosis is a rare immune-mediated blistering skin disease frequently associated with medication exposure, especially vancomycin, with men and women being equally affected. It was first described by Tadeusz Chorzelski in 1979 and may be divided into two types:

<span class="mw-page-title-main">Scleroderma</span> Group of autoimmune diseases resulting in abnormal growth of connective tissue

Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. The disease can be either localized to the skin or involve other organs, as well. Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynaud's syndrome, esophageal problems, thickening of the skin of the fingers and toes, and areas of small, dilated blood vessels.

Thymoma with immunodeficiency is a rare disorder that occurs in adults in whom hypogammaglobulinemia, deficient cell-mediated immunity, and thymoma may develop almost simultaneously. Most reported cases are in Europe, though it occurs globally.

Rheumatoid neutrophilic dermatitis, also known as rheumatoid neutrophilic dermatosis, is a cutaneous condition associated with rheumatoid arthritis.

Mouth and genital ulcers with inflamed cartilage syndrome or MAGIC syndrome refers to a condition in which an individual exhibits symptoms of both relapsing polychondritis (RP) and Behcet's disease (BD). Inflammatory ulcers in the mouth, genitalia, and skin are the hallmark of Behcet's disease (BD), a multisystem illness that is chronic and relapsing. Autoimmune recurrent chondritis of the larynx, tracheobronchial tree, nose, ears, and mouth is known as relapsing polychondritis (RP).

<span class="mw-page-title-main">Antisynthetase syndrome</span> Medical condition

Antisynthetase syndrome (ASS) is a multisystematic autoimmune disease associated with inflammatory myositis, interstitial lung disease, and antibodies directed against various synthetases of aminoacyl-transfer RNA. Other common symptoms include mechanic's hands, Raynaud's phenomenon, arthritis, and fever.

<span class="mw-page-title-main">Chronic spontaneous urticaria</span> Medical condition

Chronic spontaneous urticaria(CSU) also known as Chronic idiopathic urticaria(CIU) is defined by the presence of wheals, angioedema, or both for more than six weeks. Chronic spontaneous urticaria can be characterized by angioedema, excruciatingly itchy recurrent hives, or both. Chronic urticaria patients were found to have a higher prevalence of various autoimmune diseases. Many patients with chronic spontaneous urticaria report that certain triggers, such as stress, infections, specific foods, or nonsteroidal anti-inflammatory drug use, aggravate their condition.

<span class="mw-page-title-main">Autoimmune enteropathy</span> Medical condition

Autoimmune enteropathy is a rare autoimmune disorder characterized by weight loss from malabsorption, severe and protracted diarrhea, and autoimmune damage to the intestinal mucosa. Autoimmune enteropathy typically occurs in infants and younger children however, adult cases have been reported in literature. Autoimmune enteropathy was first described by Walker-Smith et al. in 1982.

Autoimmune polyendocrine syndrome, type 3 is a condition characterized by the coexistence of autoimmune thyroiditis and at least one other autoimmune disease. Based on other organ-specific autoimmune involvement, there are multiple subtypes that are classified: type 3a shows thyroid autoimmune disease in conjunction with type 1 diabetes, type 3b shows thyroid autoimmune disease in conjunction with pernicious anemia (PA), and type 3c shows thyroid autoimmune disease in conjunction with alopecia, vitiligo, or other organ-specific autoimmune disease.

Autoimmunity refers to a pathological immune response of the body's immune system against itself. Autoimmune disease is widely recognized to be significantly more common in women than in men, and often presents differently between the sexes. The reasons for these disparities are still under investigation, but may in part involve the presence of an additional X chromosome in women, as well as the higher presence of female sex hormones such as estrogen. The risk, incidence, and character of autoimmune disease in women may also be associated with female-specific physiological changes, such as hormonal shifts during menses, pregnancy, and menopause.

<span class="mw-page-title-main">Autoimmune urticaria</span> Autoimmune disease causing hives and itching

Autoimmune urticaria, also known as chronic autoimmune urticaria, is a type of chronic urticaria characterized by the presence of autoantibodies in the patient's immune system that target the body's own mast cells, leading to episodes of hives (urticaria). This immunologically distinct type of urticaria is considered autoimmune because the immune system, which normally protects the body from foreign organisms, mistakenly attacks the body's own cells, causing inflammation and other symptoms.

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