2,5-dihydroxypyridine 5,6-dioxygenase

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2,5-dihydroxypyridine 5,6-dioxygenase
Identifiers
EC no. 1.13.11.9
CAS no. 9029-57-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, a 2,5-dihydroxypyridine 5,6-dioxygenase (EC 1.13.11.9) is an enzyme that catalyzes the chemical reaction

Contents

2,5-dihydroxypyridine + O2 N-formylmaleamic acid

The 2 substrates of this enzyme are 2,5-dihydroxypyridine and O2, whereas its product is N-formylmaleamic acid. [1]

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. It employs one cofactor, iron.

This enzyme participates in nicotinate and nicotinamide metabolism. [2]

Nomenclature

The systematic name of this enzyme class is 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase. Other names in common use include 2,5-dihydroxypyridine oxygenase, and pyridine-2,5-diol dioxygenase.

References

  1. Q88FY1
  2. Henke, Matthew T.; Snider, Mark J. (1 April 2011). "Mechanistic studies of 2,5-dihydroxypyridine 5,6-dioxygenase (NicX) from Bordetella bronchiseptica". The FASEB Journal. 25 (1 Supplement): 714.2. doi: 10.1096/fasebj.25.1_supplement.714.2 (inactive 11 July 2025). ISSN   0892-6638 . Retrieved 13 February 2017.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)

Further reading