2,5-dihydroxypyridine 5,6-dioxygenase

2,5-dihydroxypyridine 5,6-dioxygenase
Identifiers
EC no.	1.13.11.9
CAS no.	9029-57-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2,5-dihydroxypyridine 5,6-dioxygenase (EC 1.13.11.9) is an enzyme that catalyzes the chemical reaction

2,5-dihydroxypyridine + O₂${\displaystyle \rightleftharpoons }$ N-formylmaleamic acid

The 2 substrates of this enzyme are 2,5-dihydroxypyridine and O₂, whereas its product is N-formylmaleamic acid. ^[1]

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. It employs one cofactor, iron.

This enzyme participates in nicotinate and nicotinamide metabolism. ^[2]

Nomenclature

The systematic name of this enzyme class is 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase. Other names in common use include 2,5-dihydroxypyridine oxygenase, and pyridine-2,5-diol dioxygenase.

References

1. Q88FY1
2. Henke, Matthew T.; Snider, Mark J. (1 April 2011). "Mechanistic studies of 2,5-dihydroxypyridine 5,6-dioxygenase (NicX) from Bordetella bronchiseptica". The FASEB Journal. 25 (1 Supplement): 714.2. doi: 10.1096/fasebj.25.1_supplement.714.2 (inactive 2024-09-12). ISSN   0892-6638 . Retrieved 13 February 2017.

Further reading

• Behrman EJ, Stanier RY (1957). "The bacterial oxidation of nicotinic acid". J. Biol. Chem. 228 (2): 923–45. doi: 10.1016/S0021-9258(18)70671-6 . PMID   13475371.
• Gauthier JJ, Rittenberg SC (1971). "The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9". J. Biol. Chem. 246 (11): 3737–42. doi: 10.1016/S0021-9258(18)62189-1 . PMID   5578917.
• Gauthier JJ, Rittenberg SC (1971). "The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation". J. Biol. Chem. 246 (11): 3743–8. doi: 10.1016/S0021-9258(18)62190-8 . PMID   5578918.
• Behrman EJ (November 2008). "N-Formylmaleamic acid: an intermediate in nicotinic acid metabolism". Proc. Natl. Acad. Sci. U.S.A. 105 (47): E88, author reply E89. Bibcode:2008PNAS..105E..88B. doi: 10.1073/pnas.0808695105 . PMC   2587544 . PMID   19020104.