| 2021 Los Cabos Open | |
|---|---|
| Date | 19–25 July |
| Edition | 5th |
| Draw | 28S / 16D |
| Surface | Hard |
| Location | Los Cabos, Mexico |
| Champions | |
| Singles | |
 Cameron Norrie | |
| Doubles | |
 Hans Hach Verdugo /  John Isner | |
The 2021 Los Cabos Open (known as the Mifel Open for sponsorship reasons) was an ATP tennis tournament played on outdoor hardcourt. It was the 5th edition of the tournament, and part of the ATP Tour 250 series of the 2021 ATP Tour. It took place in Los Cabos, Mexico from 19 July through 25 July 2021. [1]
Cameron Norrie def. Brandon Nakashima 6–2, 6–2. Hans Hach Verdugo / John Isner def. Hunter Reese / 
Sem Verbeek 5–7, 6–2, [10–4].| Event | W | F | SF | QF | Round of 16 | Round of 32 | Q | Q2 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 0 | 12 | 6 | 0 |
|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 | — | — | — | — |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | Q2 | Q1 |
| Singles | €58,705 | €42,095 | €29,965 | €19,975 | €12,840 | €7,730 | €3,775 | €1,960 |
| Doubles* | €21,920 | €15,690 | €10,340 | €6,720 | €3,940 | — | — | — |
*per team
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| GBR | Cameron Norrie | 32 | 1 |
| USA | John Isner | 34 | 2 |
| USA | Taylor Fritz | 40 | 3 |
| USA | Sam Querrey | 68 | 4 |
 AUS | Jordan Thompson | 71 | 5 |
| USA | Steve Johnson | 83 | 6 |
 ITA | Andreas Seppi | 87 | 7 |
| USA | Mackenzie McDonald | 103 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Kevin Anderson → replaced by 
Elias Ymer 
Ričardas Berankis → replaced by 
Jurij Rodionov 
Grigor Dimitrov → replaced by Brandon Nakashima James Duckworth → replaced by 
Yasutaka Uchiyama 
Daniel Elahi Galán → replaced by 
Emilio Gómez 
Egor Gerasimov → replaced by 
Evgeny Donskoy Ilya Ivashka → replaced by Sebastian Ofner Sebastian Korda → replaced by 
Peter Gojowczyk 
Adrian Mannarino → replaced by J. J. Wolf 
Guido Pella → replaced by Alex Bolt | Country | Player | Country | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| GBR | Luke Bambridge | GBR | Ken Skupski | 126 | 1 |
 ISR | Jonathan Erlich | MEX | Santiago González | 126 | 2 |
 PAK | Aisam-ul-Haq Qureshi |  IND | Divij Sharan | 135 | 3 |
| AUS | Matthew Ebden | AUS | John-Patrick Smith | 145 | 4 |
The following pairs received wildcards into the doubles main draw:
Marcelo Arévalo / Miguel Ángel Reyes-Varela → replaced by 
Harri Heliövaara / Miguel Ángel Reyes-Varela Ričardas Berankis / Harri Heliövaara → replaced by Sriram Balaji / 
Luca Margaroli Lloyd Glasspool / Cameron Norrie → replaced by Evgeny Donskoy / 
Illya Marchenko Matt Reid / Jordan Thompson → replaced by Alex Bolt / Jordan Thompson 