9,12-octadecadienoate 8-hydroperoxide 8S-isomerase

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9,12-octadecadienoate 8-hydroperoxide 8S-isomerase
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EC no. 5.4.4.6
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9,12-octadecadienoate 8-hydroperoxide 8S-isomerase (EC 5.4.4.6, 8-hydroperoxide isomerase, (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-7,8-dihydroxy-9,12-octadecadienoate-forming)) is an enzyme with systematic name (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase ((7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate-forming). [1] [2] [3] This enzyme catalyses the following chemical reaction

(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate

This enzyme contains heme.

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9,12-octadecadienoate 8-hydroperoxide 8R-isomerase is an enzyme with systematic name (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase ( -5,8-dihydroxyoctadeca-9,12-dienoate-forming). This enzyme catalyses the following chemical reaction

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References

  1. Hamberg M, Zhang LY, Brodowsky ID, Oliw EH (February 1994). "Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions". Archives of Biochemistry and Biophysics. 309 (1): 77–80. doi:10.1006/abbi.1994.1087. PMID   8117115.
  2. Su C, Sahlin M, Oliw EH (August 1998). "A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities". The Journal of Biological Chemistry. 273 (33): 20744–51. doi: 10.1074/jbc.273.33.20744 . PMID   9694817.
  3. Su C, Oliw EH (June 1996). "Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein". The Journal of Biological Chemistry. 271 (24): 14112–8. doi: 10.1074/jbc.271.24.14112 . PMID   8662736.