Lupeol synthase

Lupeol synthase
Identifiers
EC no.	5.4.99.41
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Lupeol synthase (EC 5.4.99.41, LUPI, BPW, RcLUS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lupeol-forming). ^{[1] [2] [3] [4] [5] [6] [7]} This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene ${\displaystyle \rightleftharpoons }$ lupeol

Also forms some beta-amyrin.

References

1. Herrera JB, Bartel B, Wilson WK, Matsuda SP (December 1998). "Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene". Phytochemistry. 49 (7): 1905–11. doi:10.1016/s0031-9422(98)00366-5. PMID   9883589.
2. Shibuya M, Zhang H, Endo A, Shishikura K, Kushiro T, Ebizuka Y (November 1999). "Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases". European Journal of Biochemistry. 266 (1): 302–7. doi: 10.1046/j.1432-1327.1999.00875.x . PMID   10542078.
3. Segura MJ, Meyer MM, Matsuda SP (July 2000). "Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol". Organic Letters. 2 (15): 2257–9. doi:10.1021/ol006016b. PMID   10930257.
4. Zhang H, Shibuya M, Yokota S, Ebizuka Y (May 2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biological & Pharmaceutical Bulletin. 26 (5): 642–50. doi: 10.1248/bpb.26.642 . PMID   12736505.
5. Hayashi H, Huang P, Takada S, Obinata M, Inoue K, Shibuya M, Ebizuka Y (July 2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biological & Pharmaceutical Bulletin. 27 (7): 1086–92. doi: 10.1248/bpb.27.1086 . PMID   15256745.
6. Guhling O, Hobl B, Yeats T, Jetter R (April 2006). "Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis". Archives of Biochemistry and Biophysics. 448 (1–2): 60–72. doi:10.1016/j.abb.2005.12.013. PMID   16445885.
7. Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K (October 2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". The FEBS Journal. 274 (19): 5028–42. doi: 10.1111/j.1742-4658.2007.06025.x . PMID   17803686.

External links

• Lupeol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)