A. W. F. Edwards | |
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Born | Anthony William Fairbank Edwards 4 October 1935 [1] London, [1] England |
Education | University of Cambridge |
Parent |
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Relatives | John H. Edwards (brother) |
Scientific career | |
Fields | Statistics, genetics |
Institutions | |
Doctoral students | Elizabeth A. Thompson |
Website | royalsociety |
Anthony William Fairbank Edwards, FRS [2] (born 1935) is a British statistician, geneticist and evolutionary biologist. Edwards is regarded as one of Britain's most distinguished geneticists, [3] and as one of the most influential mathematical geneticists in the history. [4] He is the son of the surgeon Harold C. Edwards, and brother of medical geneticist John H. Edwards. Edwards has sometimes been called "Fisher's Edwards" to distinguish him from his brother, because he was mentored by Ronald Fisher. [5] He has always had a high regard for Fisher's scientific contributions and has written extensively on them. To mark the Fisher centenary in 1990, Edwards proposed a commemorative Sir Ronald Fisher window be installed in the Dining Hall of Gonville & Caius College. When the window was removed in 2020, he vigorously opposed the move. [6]
In 1963 and 1964, Edwards, along with Luigi Luca Cavalli-Sforza, introduced novel methods for computing evolutionary trees from genetical data. [7]
Edwards is a Life Fellow of Gonville and Caius College, Cambridge [8] and retired Professor of Biometry at the University of Cambridge, and holds both the ScD and LittD degrees. He has written several books and numerous scientific papers. [9] With Luigi Luca Cavalli-Sforza, he carried out pioneering work on quantitative methods of phylogenetic analysis, and he has strongly advocated Fisher's concept of likelihood as the proper basis for statistical and scientific inference. He has also written extensively on the history of genetics and statistics, including an analysis of whether Gregor Mendel's results were "too good" to be unmanipulated, [10] and also on purely mathematical subjects, such as Venn diagrams. [11] [12] [13] [14] [15] [16]
After one postdoctoral research year he was invited by Luigi Luca Cavalli-Sforza to the University of Pavia, where, in 1961–1964, they initiated the statistical approach to the construction of evolutionary trees from genetical data, using the first modern computers. A year at Stanford University was followed by three years as a senior lecturer in Statistics at the University of Aberdeen supervised by D. J. Finney and then two years as a Bye-Fellow in Science at Gonville and Caius College, Cambridge, during which he wrote his book Likelihood. [2]
The remainder of Edwards's career has been spent at Cambridge, ultimately as Professor of Biometry, during which he has published widely, including books on Venn diagrams, mathematical genetics, and Pascal's triangle. [2] In a 2003 paper, Edwards criticised Richard Lewontin's argument in a 1972 paper that race is an invalid taxonomic construct, terming it Lewontin's fallacy. [17] [18]
(Contains: selected papers, including all the papers below; short commentaries by expert biologists, historians, and philosophers; interview with Edwards; appendices; a full list of publications up to 2016.)
Edwards was elected a Fellow of the Royal Society (FRS) in 2015. [2]
His elder brother John H. Edwards (1928–2007) was also a geneticist and also an FRS; their father, Harold C. Edwards, was a surgeon. He was awarded the Telesio-Galilei Academy Award in 2011 for Biology.
Edwards is involved in gliding, particularly within the Cambridge University Gliding Club and has written on the subject in Sailplane and Gliding magazine as "The Armchair Pilot".
Gregor Johann MendelOSA was an Austrian-Czech biologist, meteorologist, mathematician, Augustinian friar and abbot of St. Thomas' Abbey in Brno (Brünn), Margraviate of Moravia. Mendel was born in a German-speaking family in the Silesian part of the Austrian Empire and gained posthumous recognition as the founder of the modern science of genetics. Though farmers had known for millennia that crossbreeding of animals and plants could favor certain desirable traits, Mendel's pea plant experiments conducted between 1856 and 1863 established many of the rules of heredity, now referred to as the laws of Mendelian inheritance.
In biology, phylogenetics is the study of the evolutionary history and relationships among or within groups of organisms. These relationships are determined by phylogenetic inference, methods that focus on observed heritable traits, such as DNA sequences, protein amino acid sequences, or morphology. The result of such an analysis is a phylogenetic tree—a diagram containing a hypothesis of relationships that reflects the evolutionary history of a group of organisms.
The modern synthesis was the early 20th-century synthesis of Charles Darwin's theory of evolution and Gregor Mendel's ideas on heredity into a joint mathematical framework. Julian Huxley coined the term in his 1942 book, Evolution: The Modern Synthesis. The synthesis combined the ideas of natural selection, Mendelian genetics, and population genetics. It also related the broad-scale macroevolution seen by palaeontologists to the small-scale microevolution of local populations.
Sir Ronald Aylmer Fisher was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic. For his work in statistics, he has been described as "a genius who almost single-handedly created the foundations for modern statistical science" and "the single most important figure in 20th century statistics". In genetics, Fisher was the one to most comprehensively combine the ideas of Gregor Mendel and Charles Darwin, as his work used mathematics to combine Mendelian genetics and natural selection; this contributed to the revival of Darwinism in the early 20th-century revision of the theory of evolution known as the modern synthesis. For his contributions to biology, Richard Dawkins declared Fisher to be the greatest of Darwin's successors. He is also considered one of the founding fathers of Neo-Darwinism. According to statistician Jeffrey T. Leek, Fisher is the most influential scientist of all time based off the number of citations of his contributions.
Luigi Luca Cavalli-Sforza was an Italian geneticist. He was a population geneticist who taught at the University of Parma, the University of Pavia and then at Stanford University.
John Venn, FRS, FSA was an English mathematician, logician and philosopher noted for introducing Venn diagrams, which are used in logic, set theory, probability, statistics, and computer science. In 1866, Venn published The Logic of Chance, a groundbreaking book which espoused the frequency theory of probability, arguing that probability should be determined by how often something is forecast to occur as opposed to "educated" assumptions. Venn then further developed George Boole's theories in the 1881 work Symbolic Logic, where he highlighted what would become known as Venn diagrams.
Phylogenesis is the biological process by which a taxon appears. The science that studies these processes is called phylogenetics.
Richard Charles Lewontin was an American evolutionary biologist, mathematician, geneticist, and social commentator. A leader in developing the mathematical basis of population genetics and evolutionary theory, he applied techniques from molecular biology, such as gel electrophoresis, to questions of genetic variation and evolution.
Genetic variation is the difference in DNA among individuals or the differences between populations among the same species. The multiple sources of genetic variation include mutation and genetic recombination. Mutations are the ultimate sources of genetic variation, but other mechanisms, such as genetic drift, contribute to it, as well.
The Punnett square is a square diagram that is used to predict the genotypes of a particular cross or breeding experiment. It is named after Reginald C. Punnett, who devised the approach in 1905. The diagram is used by biologists to determine the probability of an offspring having a particular genotype. The Punnett square is a tabular summary of possible combinations of maternal alleles with paternal alleles. These tables can be used to examine the genotypical outcome probabilities of the offspring of a single trait (allele), or when crossing multiple traits from the parents.
Researchers have investigated the relationship between race and genetics as part of efforts to understand how biology may or may not contribute to human racial categorization. Today, the consensus among scientists is that race is a social construct, and that using it as a proxy for genetic differences among populations is misleading.
Reginald Crundall Punnett FRS was a British geneticist who co-founded, with William Bateson, the Journal of Genetics in 1910. Punnett is probably best remembered today as the creator of the Punnett square, a tool still used by biologists to predict the probability of possible genotypes of offspring. His Mendelism (1905) is sometimes said to have been the first textbook on genetics; it was probably the first popular science book to introduce genetics to the public.
"Human Genetic Diversity: Lewontin's Fallacy" is a 2003 paper by A. W. F. Edwards. He criticises an argument first made in Richard Lewontin's 1972 article "The Apportionment of Human Diversity", that the practice of dividing humanity into races is taxonomically invalid because any given individual will often have more in common genetically with members of other population groups than with members of their own. Edwards argued that this does not refute the biological reality of race since genetic analysis can usually make correct inferences about the perceived race of a person from whom a sample is taken, and that the rate of success increases when more genetic loci are examined.
Robert Heath Lock was an English botanist and geneticist who wrote the first English textbook on genetics.
Sir John Ellys or Ellis (1634?–1716) was an English academic, Master of Gonville and Caius College, Cambridge from 1703.
Rev. Hamnet Holditch, also spelled Hamnett Holditch, was an English mathematician who was President of Gonville and Caius College, Cambridge. In 1858, he introduced the result in geometry now known as Holditch's theorem.
James Halman was an academic of the University of Cambridge. He held the office of Registrary of the university from 1683 to 1701 and was also the twenty-third Master of Gonville and Caius College.
Richard Fisher Belward was an English priest and academic. He was born Richard Fisher, adopting the name Belward in 1791.
A stained glass window commemorating British statistician, geneticist, and eugenicist R. A. Fisher was installed in the dining hall of Gonville and Caius College in Cambridge, England in 1989. It depicts a 7x7 Latin square, as featured in Fisher's The Design of Experiments. The idea for the window came from college fellow, A. W. F. Edwards, and the execution was the work of Maria McClafferty.
"The Apportionment of Human Diversity" is a 1972 paper on racial categorisation by American evolutionary biologist Richard Lewontin. In it, Lewontin presented an analysis of genetic diversity amongst people from different conventionally-defined races. His main finding, that there is more genetic variation within these populations than between them, is considered a landmark in the study of human genetic variation and contributed to the abandonment of race as a scientific concept.
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