A. W. F. Edwards

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A. W. F. Edwards

FRS
Anthony William Fairbank Edwards FRS.jpg
Edwards at the Royal Society admissions day in 2015
Born
Anthony William Fairbank Edwards

(1935-10-04) 4 October 1935 (age 88) [1]
London, [1] England
Education University of Cambridge
Parent
Relatives John H. Edwards (brother)
Awards Fellow of the Royal Society (2015) [2]
Scientific career
FieldsStatistics, genetics
Institutions
Doctoral students Elizabeth A. Thompson
Website royalsociety.org/people/anthony-edwards-11379/

Anthony William Fairbank Edwards, FRS [2] (born 1935) is a British statistician, geneticist and evolutionary biologist. He is the son of the surgeon Harold C. Edwards, and brother of medical geneticist John H. Edwards. He has sometimes been called "Fisher's Edwards" to distinguish him from his brother, because he was mentored by Ronald Fisher. [3] Edwards has always had a high regard for Fisher's scientific contributions and has written extensively on them. To mark the Fisher centenary in 1990, Edwards proposed a commemorative Sir Ronald Fisher window be installed in the Dining Hall of Gonville & Caius College. When the window was removed in 2020, he vigorously opposed the move. [4]

Contents

Career and research

6-set Edwards-Venn diagram Edwards-Venn-six.svg
6-set Edwards–Venn diagram

Edwards is a Life Fellow of Gonville and Caius College, Cambridge [5] and retired Professor of Biometry at the University of Cambridge, and holds both the ScD and LittD degrees. He has written several books and numerous scientific papers. [6] With Luigi Luca Cavalli-Sforza, he carried out pioneering work on quantitative methods of phylogenetic analysis, and he has strongly advocated Fisher's concept of likelihood as the proper basis for statistical and scientific inference. He has also written extensively on the history of genetics and statistics, including an analysis of whether Gregor Mendel's results were "too good" to be unmanipulated, [7] and also on purely mathematical subjects, such as Venn diagrams. [8] [9] [10] [11] [12] [13]

After one postdoctoral research year he was invited by Luigi Luca Cavalli-Sforza to the University of Pavia, where, in 1961–1964, they initiated the statistical approach to the construction of evolutionary trees from genetical data, using the first modern computers. A year at Stanford University was followed by three years as a senior lecturer in Statistics at the University of Aberdeen supervised by D. J. Finney and then two years as a Bye-Fellow in Science at Gonville and Caius College, Cambridge, during which he wrote his book Likelihood. [2]

The remainder of Edwards's career has been spent at Cambridge, ultimately as Professor of Biometry, during which he has published widely, including books on Venn diagrams, mathematical genetics, and Pascal's triangle. [2] In a 2003 paper, Edwards criticised Richard Lewontin's argument in a 1972 paper that race is an invalid taxonomic construct, terming it Lewontin's fallacy. [14] [15]

Works

Books

Anthology

(Contains: selected papers, including all the papers below; short commentaries by expert biologists, historians, and philosophers; interview with Edwards; appendices; a full list of publications up to 2016.)

Papers

Awards and honours

Edwards was elected a Fellow of the Royal Society (FRS) in 2015. [2]

Personal life

His elder brother John H. Edwards (1928–2007) was also a geneticist and also an FRS; their father, Harold C. Edwards, was a surgeon. He was awarded the Telesio-Galilei Academy Award in 2011 for Biology.

Edwards is involved in gliding, particularly within the Cambridge University Gliding Club and has written on the subject in Sailplane and Gliding magazine as "The Armchair Pilot".

Related Research Articles

<span class="mw-page-title-main">Gregor Mendel</span> Augustinian friar and scientist (1822–1884)

Gregor Johann MendelOSA was an Austrian-Czech biologist, meteorologist, mathematician, Augustinian friar and abbot of St. Thomas' Abbey in Brno (Brünn), Margraviate of Moravia. Mendel was born in a German-speaking family in the Silesian part of the Austrian Empire and gained posthumous recognition as the founder of the modern science of genetics. Though farmers had known for millennia that crossbreeding of animals and plants could favor certain desirable traits, Mendel's pea plant experiments conducted between 1856 and 1863 established many of the rules of heredity, now referred to as the laws of Mendelian inheritance.

In statistics, the likelihood principle is the proposition that, given a statistical model, all the evidence in a sample relevant to model parameters is contained in the likelihood function.

<span class="mw-page-title-main">Ronald Fisher</span> British polymath (1890–1962)

Sir Ronald Aylmer Fisher was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic. For his work in statistics, he has been described as "a genius who almost single-handedly created the foundations for modern statistical science" and "the single most important figure in 20th century statistics". In genetics, his work used mathematics to combine Mendelian genetics and natural selection; this contributed to the revival of Darwinism in the early 20th-century revision of the theory of evolution known as the modern synthesis, being the one to most comprehensively combine the ideas of Gregor Mendel and Charles Darwin. For his contributions to biology, Richard Dawkins proclaimed Fisher as "the greatest of Darwin's successors". He is considered one of the founding fathers of Neo-Darwinism.

<span class="mw-page-title-main">Luigi Luca Cavalli-Sforza</span> Italian population geneticist (1922–2018)

Luigi Luca Cavalli-Sforza was an Italian geneticist. He was a population geneticist who taught at the University of Parma, the University of Pavia and then at Stanford University.

<span class="mw-page-title-main">John Venn</span> English logician and philosopher (1834–1923)

John Venn, FRS, FSA was an English mathematician, logician and philosopher noted for introducing Venn diagrams, which are used in logic, set theory, probability, statistics, and computer science. In 1866, Venn published The Logic of Chance, a groundbreaking book which espoused the frequency theory of probability, arguing that probability should be determined by how often something is forecast to occur as opposed to "educated" assumptions. Venn then further developed George Boole's theories in the 1881 work Symbolic Logic, where he highlighted what would become known as Venn diagrams.

<span class="mw-page-title-main">Phylogenesis</span>

Phylogenesis is the biological process by which a taxon appears. The science that studies these processes is called phylogenetics.

<span class="mw-page-title-main">Richard Lewontin</span> American evolutionary biologist and mathematician (1929–2021)

Richard Charles Lewontin was an American evolutionary biologist, mathematician, geneticist, and social commentator. A leader in developing the mathematical basis of population genetics and evolutionary theory, he applied techniques from molecular biology, such as gel electrophoresis, to questions of genetic variation and evolution.

<span class="mw-page-title-main">Genetic variation</span> Difference in DNA among individuals or populations

Genetic variation is the difference in DNA among individuals or the differences between populations among the same species. The multiple sources of genetic variation include mutation and genetic recombination. Mutations are the ultimate sources of genetic variation, but other mechanisms, such as genetic drift, contribute to it, as well.

<span class="mw-page-title-main">Punnett square</span> Tabular summary of genetic combinations

The Punnett square is a square diagram that is used to predict the genotypes of a particular cross or breeding experiment. It is named after Reginald C. Punnett, who devised the approach in 1905. The diagram is used by biologists to determine the probability of an offspring having a particular genotype. The Punnett square is a tabular summary of possible combinations of maternal alleles with paternal alleles. These tables can be used to examine the genotypical outcome probabilities of the offspring of a single trait (allele), or when crossing multiple traits from the parents. The Punnett square is a visual representation of Mendelian inheritance, a fundamental concept in genetics which is discovery of Gregor Mendel. For multiple traits, using the "forked-line method" is typically much easier than the Punnett square. Phenotypes may be predicted with at least better-than-chance accuracy using a Punnett square, but the phenotype that may appear in the presence of a given genotype can in some instances be influenced by many other factors, as when polygenic inheritance and/or epigenetics are at work.

Researchers have investigated the relationship between race and genetics as part of efforts to understand how biology may or may not contribute to human racial categorization. Today, the consensus among scientists is that race is a social construct, and that using it as a proxy for genetic differences among populations is misleading.

<span class="mw-page-title-main">Reginald Punnett</span> British geneticist

Reginald Crundall Punnett FRS was a British geneticist who co-founded, with William Bateson, the Journal of Genetics in 1910. Punnett is probably best remembered today as the creator of the Punnett square, a tool still used by biologists to predict the probability of possible genotypes of offspring. His Mendelism (1905) is sometimes said to have been the first textbook on genetics; it was probably the first popular science book to introduce genetics to the public.

"Human Genetic Diversity: Lewontin's Fallacy" is a 2003 paper by A. W. F. Edwards. He criticises an argument first made in Richard Lewontin's 1972 article "The Apportionment of Human Diversity", that the practice of dividing humanity into races is taxonomically invalid because any given individual will often have more in common genetically with members of other population groups than with members of their own. Edwards argued that this does not refute the biological reality of race since genetic analysis can usually make correct inferences about the perceived race of a person from whom a sample is taken, and that the rate of success increases when more genetic loci are examined.

<span class="mw-page-title-main">Genetic distance</span> Measure of divergence between populations

Genetic distance is a measure of the genetic divergence between species or between populations within a species, whether the distance measures time from common ancestor or degree of differentiation. Populations with many similar alleles have small genetic distances. This indicates that they are closely related and have a recent common ancestor.

Henry Cobden Haslam was a British medical researcher and Conservative Party politician.

In statistics, the method of support is a technique that is used to make inferences from datasets.

<span class="mw-page-title-main">Robert Heath Lock</span>

Robert Heath Lock was an English botanist and geneticist who wrote the first English textbook on genetics.

<span class="mw-page-title-main">John Ellys (Caius)</span> English academic (d. 1716)

Sir John Ellys or Ellis (1634?–1716) was an English academic, Master of Gonville and Caius College, Cambridge from 1703.

<span class="mw-page-title-main">James Halman</span>

James Halman was an academic of the University of Cambridge. He held the office of Registrary of the university from 1683 to 1701 and was also the twenty-third Master of Gonville and Caius College.

<span class="mw-page-title-main">Richard Fisher Belward</span> English scholar (1746–1803)

Richard Fisher Belward was an English priest and academic. He was born Richard Fisher, adopting the name Belward in 1791.

<span class="mw-page-title-main">Sir Ronald Fisher window</span> Stained glass window commemorating Sir Ronald Fisher

A stained glass window commemorating British statistician, geneticist, and eugenicist R. A. Fisher was installed in the dining hall of Gonville and Caius College in Cambridge, England in 1989. It depicts a 7x7 Latin square, as featured in Fisher's The Design of Experiments. The idea for the window came from college fellow, A. W. F. Edwards, and the execution was the work of Maria McClafferty.

References

  1. 1 2 "Edwards, Prof. Anthony William Fairbank" . Who's Who (online Oxford University Press  ed.). Oxford: A & C Black. 2016.(Subscription or UK public library membership required.)
  2. 1 2 3 4 5 "Professor Anthony (A.W.F.) Edwards FRS". London: Royal Society. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." -- "Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  3. Winther, Rasmus Grønfeldt (2018). Phylogenetic Inference, Selection Theory, and History of Science: Selected Papers of A. W. F. Edwards with Commentaries. Cambridge, U.K.: Cambridge University Press. p. 519. ISBN   9781107111721.
  4. Edwards, A.W.F (March 2021). "Cancelled by his college". The Critic.
  5. "Professor Anthony Edwards". Gonville & Caius College. 30 January 2013. Retrieved 2 May 2015.
  6. A list of publications up to 2009
  7. Edwards, A. W. F. (1986). "Are Mendel's Results Really Too Close?". Biological Reviews. 61 (4): 295–312. doi:10.1111/j.1469-185X.1986.tb00656.x. PMID   3542070. S2CID   42928841.
  8. "A Realised Path: The Cambridge Statistical Laboratory upto (sic) 1993 (revised 2002)". Archived from the original on 19 December 2013. Retrieved 14 January 2006.
  9. "Cambridge University Library photograph of Edwards as Chairman of the Library Syndicate making a presentation to the President of Israel". Archived from the original on 20 September 2006. Retrieved 17 April 2006.
  10. Edwards inspired the window in the Hall of Caius College, celebrating Venn and Fisher, former fellows and heroes of Edwards
  11. A collection of R. A. Fisher quotations compiled by A.W.F. Edwards
  12. Kiernan, Jim. "Review of Cogwheels of the Mind". Mathematical Association of America. Retrieved 2 May 2015.
  13. Felsenstein, J. (2004). Inferring Phylogenies. Sinauer, Sunderland, Mass. ISBN   0-87893-177-5
  14. Edwards, A. W. F. (2003). "Human Genetic Diversity: Lewontin's Fallacy". BioEssays. 25 (8): 798–801. doi:10.1002/bies.10315. PMID   12879450.
  15. Winther, Rasmus Grønfeldt (2018). Phylogenetic Inference, Selection Theory, and History of Science: Selected Papers of A. W. F. Edwards with Commentaries. Cambridge, U.K.: Cambridge University Press. ISBN   9781107111721.