Stephen D. M. Brown

Last updated

Steve Brown

FRS FMedSci
Professor Steve David Macleod Brown FRS.jpg
Steve Brown at the Royal Society admissions day in London, July 2015
Born
Stephen David Macleod Brown

(1955-05-03) 3 May 1955 (age 68) [1]
Dumfries, Scotland [1]
Education Belfast Royal Academy
Alma mater University of Cambridge (BA, PhD)
Scientific career
Fields
Institutions
Thesis The molecular organisation and evolution of rodent genomes  (1981)
Doctoral advisor Gabriel Dover [5] [6] [7]
Doctoral students Elizabeth Fisher [8]
Website har.mrc.ac.uk/research/lifetime-studies/genetics-and-pathobiology-deafness

Steve David Macleod Brown FRS FMedSci [9] [2] is director of the Medical Research Council (MRC) Mammalian Genetics Unit, MRC Harwell at Harwell Science and Innovation Campus, Oxfordshire, [9] [10] [11] [12] [13] a research centre on mouse genetics. In addition, he leads the Genetics and Pathobiology of Deafness research group. [14]

Contents

Education

Brown was educated at Belfast Royal Academy [1] and St Catharine's College, Cambridge, where he was awarded a Bachelor of Arts degree in 1977 [1] followed by a PhD in 1981 for research on the molecular organisation and evolution of rodent genomes [15] supervised by Gabriel Dover. [5]

Career and research

Brown conducts research in mouse genetics and genomics. He has studied repeated sequences in the DNA of mice and produced molecular maps of mouse chromosomes, which were used to sequence the mouse genome. [5] [9] [16] He subsequently pioneered efforts to functionally annotate the mouse genome and identify and generate novel disease models through mutagenesis and phenotyping. In particular, he has identified key proteins involved in hearing, contributing to the understanding of the genetics of deafness. [9] For example, research in Brown's laboratory has shown that a mutation in the Evi1 gene increases susceptibility to inflammation of the middle ear (otitis media) in mice, leading to hearing loss. [17]

A particular focus has been the use of mouse models to elucidate the molecular basis of genetic deafness. With Karen Steel, he discovered myosin VIIA as the gene underlying the shaker-1 mutant – one of the first deafness genes to be identified. [18]

Prior to being appointed director of Harwell in 1998, Brown was a professor at Imperial College London. [19] He is chair of the International Mouse Phenotyping Consortium steering committee and joint editor-in-chief of the journal Mammalian Genome . [20] [21]

Awards and honours

Brown was awarded The Genetics Society Medal in 2009,[ citation needed ] elected a Fellow of the Academy of Medical Sciences in 2001, [2] and elected a Fellow of the Royal Society (FRS) in 2015. [9] [18] His certificate of election reads:

Stephen Brown is distinguished for his research in mouse genetics and genomics. He pioneered studies of repeated sequences in the mouse genome and the use of novel approaches to generate molecular maps of mouse chromosomes, work that underpinned the sequencing of the mouse genome. He has been at the forefront of new approaches in mutagenesis and phenotyping for the functional annotation of the mouse genome and the identification and characterisation of disease models. Notably, in collaboration he has utilised the mouse to study the genetics of deafness, identifying key proteins involved in auditory transduction, which has transformed our understanding in this field. [9]

Related Research Articles

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References

  1. 1 2 3 4 Anon (2016). "Brown, Stephen David Macleod" . Who's Who (online Oxford University Press  ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U284101.(Subscription or UK public library membership required.)
  2. 1 2 3 "Professor Steve Brown FRS FMedSci". London: Academy of Medical Sciences. Archived from the original on 4 June 2015.
  3. ↑ Brown, S. D.; Hancock, J. M.; Gates, H (2006). "Understanding mammalian genetic systems: The challenge of phenotyping in the mouse". PLOS Genetics. 2 (8): e118. doi:10.1371/journal.pgen.0020118. PMC   1557775 . PMID   16933996.
  4. ↑ Steel, Karen P.; Brown, Stephen D.M. (1994). "Genes and deafness". Trends in Genetics. 10 (12): 428–35. doi:10.1016/0168-9525(94)90113-9. PMID   7871592.
  5. 1 2 3 Brown, S. D. M.; Dover, G. A. (1980). "Conservation of segmental variants of satellite DNA of Mus musculus in a related species: Mus spretus". Nature. 285 (5759): 47–49. Bibcode:1980Natur.285...47B. doi:10.1038/285047a0. ISSN   0028-0836. PMID   7374752. S2CID   4326610.
  6. ↑ Dover, G. A.; Strachan, T; Coen, E. S.; Brown, S. D. (1982). "Molecular drive". Science. 218 (4577): 1069. Bibcode:1982Sci...218.1069D. doi:10.1126/science.7146895. PMID   7146894.
  7. ↑ Brown, S. D.; Dover, G (1981). "Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes". Journal of Molecular Biology. 150 (4): 441–66. doi:10.1016/0022-2836(81)90374-0. PMID   6276556.
  8. ↑ Fisher, Elizabeth Mary Claire (1987). Microcloning and molecular mapping of the mouse X chromosome. london.ac.uk (PhD thesis). University of London. hdl:10044/1/66999. OCLC   1103939662. EThOS   uk.bl.ethos.769180. Lock-green.svg
  9. 1 2 3 4 5 6 Anon (2015). "Professor Stephen Brown FMedSci FRS". London: Royal Society. Archived from the original on 2 May 2015.
  10. ↑ Silver, L. M.; Nadeau, J. H.; Brown, S. D. M.; Eppig, J. T.; Peters, J (1998). "Mammalian Genome, Incorporating Mouse Genome". Mammalian Genome. 9 (1): 1. doi:10.1007/s003359900669. PMID   9435276. S2CID   42368624.
  11. ↑ Brown, S. D.; Moore, M. W. (2012). "The International Mouse Phenotyping Consortium: Past and future perspectives on mouse phenotyping". Mammalian Genome. 23 (9–10): 632–40. doi:10.1007/s00335-012-9427-x. PMC   3774932 . PMID   22940749.
  12. ↑ Brown, S. D. M.; Moore, M. W. (2012). "Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium". Disease Models & Mechanisms. 5 (3): 289–292. doi:10.1242/dmm.009878. ISSN   1754-8403. PMC   3339821 . PMID   22566555.
  13. ↑ "Profile: Steve Brown". Medical Research Council. Archived from the original on 4 June 2015.
  14. ↑ "Genetics and Pathobiology of Deafness research group". Harwell: MRC Harwell.
  15. ↑ Brown, Stephen D. M. (1981). The molecular organisation and evolution of rodent genomes. cam.ac.uk (PhD thesis). University of Cambridge. OCLC   556404448. EThOS   uk.bl.ethos.252843.
  16. ↑ Brown, S. D.; Dover, G (1981). "Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes". Journal of Molecular Biology . 150 (4): 441–66. doi:10.1016/0022-2836(81)90374-0. PMID   6276556.
  17. ↑ Parkinson, N; Hardisty-Hughes, R. E.; Tateossian, H; Tsai, H. T.; Brooker, D; Morse, S; Lalane, Z; MacKenzie, F; Fray, M; Glenister, P; Woodward, A. M.; Polley, S; Barbaric, I; Dear, N; Hough, T. A.; Hunter, A. J.; Cheeseman, M. T.; Brown, S. D. (2006). "Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media". PLOS Genetics. 2 (10): e149. doi:10.1371/journal.pgen.0020149. PMC   1592239 . PMID   17029558.
  18. 1 2 Anon (2015). "Professor Steve Brown FMedSci FRS". London: Royal Society. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." -- "Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: unfit URL (link)
  19. ↑ "MRC Harwell Timeline". Medical Research Council. Archived from the original on 24 September 2014.
  20. ↑ "Mammalian Genome: Editorial Board". Springer. Retrieved 14 August 2015.
  21. ↑ "IMPC Steering Committee". International Mouse Phenotyping Consortium.
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