Jane A. Langdale

Last updated

Jane Langdale
CBE FRS
Professor Jane Alison Langdale FRS.jpg
Jane Langdale at Royal Society admissions day in London, July 2015
Born
Jane Alison Langdale

(1960-08-25) 25 August 1960 (age 64) [1]
Coventry [1]
Education Barr's Hill School
Alma mater
Awards
Scientific career
Fields
Institutions
Thesis Gene detection using immobilised DNA probes  (1985)
Website langdalelab.com

Jane Alison Langdale, CBE FRS (born 1960) [1] is a British geneticist and academic. She is Professor of Plant Development in the Department of Biology at the University of Oxford [6] [7] and a Professorial Fellow at The Queen's College, Oxford. [8] [9] [10] [11] [12]

Contents

Education

Langdale was educated at Barr's Hill Grammar School in Coventry [1] [8] and the University of Bath, where she was awarded a Bachelor of Science degree in Applied Biology in 1982, specialising in microbiology. [13] [3] [8] Her PhD was in human genetics [13] and carried out at St Mary's Hospital Medical School [8] and Charing Cross and Westminster Medical School [14] [15] and awarded by the University of London. [16]

Career and research

Following her PhD, Langdale was employed for five years as a postdoctoral researcher at Yale University with Tim Nelson. [13] [17] She returned to the UK in 1990, to work in the Department of Plant Sciences (since 2022 the Department of Biology) where she has worked since. [13] Langdale's research interests [6] [7] [18] are in two main areas:

  1. the evolution of leaf development and meristem function in bryophytes, lycophytes and monilophytes
  2. the evolution and development of kranz anatomy in C4 plants, [19]

Langdale's research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC) [20] and has been published in leading peer reviewed scientific journals including Nature , [21] Science , [22] Current Opinion in Plant Biology , [23] Development , [24] Gene , [14] Trends in Genetics , [25] The Plant Cell , [26] [27] [28] Annual Review of Plant Biology , [29] Planta , [30] Plant Physiology , [31] Journal of Cell Science , [32] The EMBO Journal , [33] The Plant Journal, PLOS ONE [34] Genes & Development [5] and the New Phytologist . [35] [36] [37]

Langdale is the co-author of the book How to Succeed as a Scientist: From Postdoc to Professor [38] with materials scientist Barbara Gabrys. She featured on the BBC series, Plants: From Roots to Riches in 2014 with Kathy Willis. [39] [40]

Awards and honours

Langdale was elected a Fellow of the Royal Society (FRS) in 2015. [41] Her certificate of election reads:

Jane Langdale has produced a body of work that has transformed our understanding of how plants make leaves and how leaves changed during major evolutionary transitions. The breadth of her research program has led to the elucidation of mechanisms operating throughout leaf development – from the earliest stages of organ inception and specification at the shoot apex, through patterning of distinct cell-types, to chloroplast biogenesis. She has done all of this in a comparative framework and has thus advanced our understanding of leaf development not just in model flowering plant species but in species from all major land plant lineages. [42]

Langdale was elected a member of the European Molecular Biology Organization (EMBO) in 2007 [2] and appointed Commander of the Most Excellent Order of the British Empire (CBE) in the 2018 Birthday Honours for services to Plant Science. [43] [44] She was awarded a Doctor of Science degree (DSc) honoris causa by the University of Bath in 2018. [3]

She was elected a foreign associate of the National Academy of Sciences of the United States in April 2019. [4]

She was elected a corresponding member of the Australian Academy of Science in 2020.[ citation needed ]

Personal life

Langdale has always had Airedale Terriers [45] and is the elder sibling of the barrister Rachel Langdale King's Counsel (KC). [46] [47]


Related Research Articles

<span class="mw-page-title-main">Chloroplast</span> Plant organelle that conducts photosynthesis

A chloroplast is a type of membrane-bound organelle known as a plastid that conducts photosynthesis mostly in plant and algal cells. The photosynthetic pigment chlorophyll captures the energy from sunlight, converts it, and stores it in the energy-storage molecules ATP and NADPH while freeing oxygen from water in the cells. The ATP and NADPH is then used to make organic molecules from carbon dioxide in a process known as the Calvin cycle. Chloroplasts carry out a number of other functions, including fatty acid synthesis, amino acid synthesis, and the immune response in plants. The number of chloroplasts per cell varies from one, in unicellular algae, up to 100 in plants like Arabidopsis and wheat.

<span class="mw-page-title-main">Photosynthesis</span> Biological process to convert light into chemical energy

Photosynthesis is a system of biological processes by which photosynthetic organisms, such as most plants, algae, and cyanobacteria, convert light energy, typically from sunlight, into the chemical energy necessary to fuel their metabolism. Photosynthesis usually refers to oxygenic photosynthesis, a process that produces oxygen.
Photosynthetic organisms store the chemical energy so produced within intracellular organic compounds like sugars, glycogen, cellulose and starches. To use this stored chemical energy, an organism's cells metabolize the organic compounds through cellular respiration. Photosynthesis plays a critical role in producing and maintaining the oxygen content of the Earth's atmosphere, and it supplies most of the biological energy necessary for complex life on Earth.

<span class="mw-page-title-main">Plastid</span> Plant cell organelles that perform photosynthesis and store starch

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<span class="mw-page-title-main">Crassulacean acid metabolism</span> Metabolic process

Crassulacean acid metabolism, also known as CAM photosynthesis, is a carbon fixation pathway that evolved in some plants as an adaptation to arid conditions that allows a plant to photosynthesize during the day, but only exchange gases at night. In a plant using full CAM, the stomata in the leaves remain shut during the day to reduce evapotranspiration, but they open at night to collect carbon dioxide and allow it to diffuse into the mesophyll cells. The CO2 is stored as four-carbon malic acid in vacuoles at night, and then in the daytime, the malate is transported to chloroplasts where it is converted back to CO2, which is then used during photosynthesis. The pre-collected CO2 is concentrated around the enzyme RuBisCO, increasing photosynthetic efficiency. This mechanism of acid metabolism was first discovered in plants of the family Crassulaceae.

C<sub>4</sub> carbon fixation Photosynthetic process in some plants

C4 carbon fixation or the Hatch–Slack pathway is one of three known photosynthetic processes of carbon fixation in plants. It owes the names to the 1960s discovery by Marshall Davidson Hatch and Charles Roger Slack.

Christopher John Leaver is an Emeritus Professorial Fellow of St John's College, Oxford who served as Sibthorpian Professor in the Department of Plant Sciences at the University of Oxford from 1990 to 2007.

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<span class="mw-page-title-main">ABC model of flower development</span> Model for genetics of flower development

The ABC model of flower development is a scientific model of the process by which flowering plants produce a pattern of gene expression in meristems that leads to the appearance of an organ oriented towards sexual reproduction, a flower. There are three physiological developments that must occur in order for this to take place: firstly, the plant must pass from sexual immaturity into a sexually mature state ; secondly, the transformation of the apical meristem's function from a vegetative meristem into a floral meristem or inflorescence; and finally the growth of the flower's individual organs. The latter phase has been modelled using the ABC model, which aims to describe the biological basis of the process from the perspective of molecular and developmental genetics.

<span class="mw-page-title-main">Evolutionary history of plants</span>

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<span class="mw-page-title-main">Auxin binding protein</span>

In molecular biology, the auxin binding protein family is a family of proteins which bind the plant hormone auxin. They are located in the lumen of the endoplasmic reticulum (ER). The primary structure of these proteins contains an N-terminal hydrophobic leader sequence of 30-40 amino acids, which could represent a signal for translocation of the protein to the ER. The mature protein comprises around 165 residues, and contains a number of potential N-glycosylation sites. In vitro transport studies have demonstrated co-translational glycosylation. Retention within the lumen of the ER correlates with an additional signal located at the C terminus, represented by the sequence Lys-Asp-Glu-Leu, known to be responsible for preventing secretion of proteins from the lumen of the ER in eukaryotic cells.

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References

  1. 1 2 3 4 Anon (2016). "Langdale, Prof. Jane Alison" . Who's Who (online Oxford University Press  ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.284056.(Subscription or UK public library membership required.)
  2. 1 2 Anon (2007). "Jane Langdale EMBO profile". people.embo.org. European Molecular Biology Organization.
  3. 1 2 3 Scott, Rod (2018). "Professor Rod Scott's oration on Jane Langdale for the honorary degree of Doctor of Science in July 2018". bath.ac.uk. Archived from the original on 5 July 2018.
  4. 1 2 Anon (2019). "Jane A. Langdale, University of Oxford: Plant, Soil, and Microbial Sciences". nasonline.org. National Academy of Sciences.
  5. 1 2 Langdale, J A; Rothermel, B A; Nelson, T (1988). "Cellular pattern of photosynthetic gene expression in developing maize leaves". Genes & Development. 2 (1): 106–115. doi: 10.1101/gad.2.1.106 . ISSN   0890-9369. PMID   3356335.
  6. 1 2 Jane A. Langdale publications indexed by the Scopus bibliographic database. (subscription required)
  7. 1 2 Jane A. Langdale publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  8. 1 2 3 4 "Jane Langdale, The Queen's College". University of Oxford. Archived from the original on 18 February 2014.
  9. ↑ "Plant Sciences Staff: Prof. JA Langdale". University of Oxford. Archived from the original on 30 August 2013.
  10. ↑ "Jane Langdale Lab, Department of Plant Sciences". University of Oxford. Archived from the original on 15 August 2014.
  11. ↑ Interview with Jane Langdale, conference chair The EMBO Meeting 2011 on YouTube
  12. ↑ Ethics and plant science – improving food yields in a changing environment with Jane Langdale on YouTube
  13. 1 2 3 4 Langdale, Jane (2017). "Jane Langdale". Current Biology . 27 (13): R628–R629. Bibcode:2017CBio...27.R628L. doi: 10.1016/j.cub.2017.05.030 . ISSN   0960-9822.
  14. 1 2 Langdale, J. A.; Malcolm, A. D. B. (1985). "A rapid method of gene detection using DNA bound to Sephacryl". Gene. 36 (3): 201–210. doi:10.1016/0378-1119(85)90175-1. PMID   3000872.
  15. ↑ Malcolm, A. D.; Fallon, R. A.; Langdale, J. A.; Figueiredo, H; Nicholls, P. J.; Voss, U. B.; Wickenden, C; Woodhead, J. L. (1987). "DNA probes in human disease". Biochemical Society Symposium. 53: 131–43. PMID   3332764.
  16. ↑ Langdale, Jane Alison (1985). Gene detection using immobilized DNA probes. london.ac.uk (PhD thesis). University of London. OCLC   940272130. Archived from the original on 12 May 2015.
  17. ↑ Langdale, J. A.; Rothermel, B. A.; Nelson, T. (1988). "Cellular pattern of photosynthetic gene expression in developing maize leaves". Genes & Development. 2 (1): 106–115. doi: 10.1101/gad.2.1.106 . PMID   3356335.
  18. ↑ Jane A. Langdale publications from Europe PubMed Central
  19. ↑ Langdale, J. A. (2011). "C4 cycles: Past, present, and future research on C4 photosynthesis". The Plant Cell. 23 (11): 3879–92. doi:10.1105/tpc.111.092098. PMC   3246324 . PMID   22128120.
  20. ↑ "UK Government research grants awarded to Jane Langdale". Research Councils UK. Archived from the original on 6 May 2015.
  21. ↑ Harrison, C. J.; Corley, S. B.; Moylan, E. C.; Alexander, D. L.; Scotland, R. W.; Langdale, J. A. (2005). "Independent recruitment of a conserved developmental mechanism during leaf evolution". Nature. 434 (7032): 509–14. Bibcode:2005Natur.434..509H. doi:10.1038/nature03410. PMID   15791256. S2CID   4335275.
  22. ↑ Tsiantis, M; Schneeberger, R; Golz, J. F.; Freeling, M; Langdale, J. A. (1999). "The maize rough sheath2 gene and leaf development programs in monocot and dicot plants". Science. 284 (5411): 154–6. Bibcode:1999Sci...284..154T. doi:10.1126/science.284.5411.154. PMID   10102817. S2CID   43880145.
  23. ↑ Hibberd, J. M.; Sheehy, J. E.; Langdale, J. A. (2008). "Using C4 photosynthesis to increase the yield of rice—rationale and feasibility". Current Opinion in Plant Biology. 11 (2): 228–231. doi:10.1016/j.pbi.2007.11.002. PMID   18203653.
  24. ↑ Schneeberger, R; Tsiantis, M; Freeling, M; Langdale, J. A. (1998). "The rough sheath2 gene negatively regulates homeobox gene expression during maize leaf development". Development. 125 (15): 2857–65. doi:10.1242/dev.125.15.2857. PMID   9655808.
  25. ↑ Langdale, J. A.; Nelson, T. (1991). "Spatial regulation of photosynthetic development in C4 plants". Trends in Genetics. 7 (6): 191–6. doi:10.1016/0168-9525(91)90435-S. PMID   1906211.
  26. ↑ Waters, M. T.; Wang, P; Korkaric, M; Capper, R. G.; Saunders, N. J.; Langdale, J. A. (2009). "GLK transcription factors coordinate expression of the photosynthetic apparatus in Arabidopsis". The Plant Cell Online. 21 (4): 1109–28. doi:10.1105/tpc.108.065250. PMC   2685620 . PMID   19376934.
  27. ↑ Nelson, T; Langdale, J. A. (1989). "Patterns of leaf development in C4 plants". The Plant Cell Online. 1 (1): 3–13. doi:10.1105/tpc.1.1.3. PMC   159732 . PMID   2535465.
  28. ↑ Rossini, L; Cribb, L; Martin, D. J.; Langdale, J. A. (2001). "The maize golden2 gene defines a novel class of transcriptional regulators in plants". The Plant Cell. 13 (5): 1231–44. doi:10.1105/tpc.13.5.1231. PMC   135554 . PMID   11340194.
  29. ↑ Nelson, T.; Langdale, J. A. (1992). "Developmental Genetics of C4 Photosynthesis". Annual Review of Plant Physiology and Plant Molecular Biology. 43: 25–47. doi:10.1146/annurev.pp.43.060192.000325.
  30. ↑ Wang, P; Fouracre, J; Kelly, S; Karki, S; Gowik, U; Aubry, S; Shaw, M. K.; Westhoff, P; Slamet-Loedin, I. H.; Quick, W. P.; Hibberd, J. M.; Langdale, J. A. (2013). "Evolution of GOLDEN2-LIKE gene function in C3 and C4 plants". Planta. 237 (2): 481–95. Bibcode:2013Plant.237..481W. doi:10.1007/s00425-012-1754-3. PMC   3555242 . PMID   22968911.
  31. ↑ Tolley, B. J.; Sage, T. L.; Langdale, J. A.; Hibberd, J. M. (2012). "Individual maize chromosomes in the C3 plant oat can increase bundle sheath cell size and vein density". Plant Physiology . 159 (4): 1418–27. doi:10.1104/pp.112.200584. PMC   3425187 . PMID   22675083.
  32. ↑ Hodges, M. E.; Scheumann, N; Wickstead, B; Langdale, J. A.; Gull, K (2010). "Reconstructing the evolutionary history of the centriole from protein components". Journal of Cell Science. 123 (Pt 9): 1407–13. doi:10.1242/jcs.064873. PMC   2858018 . PMID   20388734.
  33. ↑ Langdale, J. A.; Zelitch, I; Miller, E; Nelson, T (1988). "Cell position and light influence C4 versus C3 patterns of photosynthetic gene expression in maize". The EMBO Journal. 7 (12): 3643–51. doi:10.1002/j.1460-2075.1988.tb03245.x. PMC   454936 . PMID   2850171.
  34. ↑ Saint-Marcoux, D; Proust, H; Dolan, L; Langdale, J. A. (2015). "Identification of Reference Genes for Real-Time Quantitative PCR Experiments in the Liverwort Marchantia polymorpha". PLOS One . 10 (3): e0118678. Bibcode:2015PLoSO..1018678S. doi: 10.1371/journal.pone.0118678 . PMC   4370483 . PMID   25798897. Open Access logo PLoS transparent.svg
  35. ↑ Sanders, H. L.; Langdale, J. A. (2013). "Conserved transport mechanisms but distinct auxin responses govern shoot patterning in Selaginella kraussiana". New Phytologist. 198 (2): 419–28. doi: 10.1111/nph.12183 . PMID   23421619.
  36. ↑ Hodges, M. E.; Wickstead, B; Gull, K; Langdale, J. A. (2012). "The evolution of land plant cilia". New Phytologist. 195 (3): 526–40. doi: 10.1111/j.1469-8137.2012.04197.x . PMID   22691130.
  37. ↑ Bravo-Garcia, A; Yasumura, Y; Langdale, J. A. (2009). "Specialization of the Golden2-like regulatory pathway during land plant evolution". New Phytologist. 183 (1): 133–41. doi: 10.1111/j.1469-8137.2009.02829.x . PMID   19383092.
  38. ↑ Gabrys, Barbara; Langdale, Jane (2012). How to succeed as a scientist: from postdoc to professor. Cambridge, UK New York: Cambridge University Press. doi:10.1017/CBO9781139015561. ISBN   978-0-521-18683-4.
  39. ↑ Willis, K. J. (2014). Kew and BBC Radio 4. London: John Murray. ISBN   978-1444798234.
  40. ↑ "Plants: From Roots to Riches, Towards the Light". bbc.co.uk. London: BBC.
  41. ↑ Anon (2015). "Professor Jane Langdale FRS". London: Royal Society. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  42. ↑ "Professor Jane Langdale FRS". London: The Royal Society. Archived from the original on 6 May 2015.
  43. ↑ "Professor Jane Langdale appointed a CBE in The Queen's Birthday Honours List - Department of Plant Sciences". plants.ox.ac.uk.
  44. ↑ "Jane LANGDALE". thegazette.co.uk. London: The London Gazette.
  45. ↑ "Pets". langdalelab.com. 7 July 2015.
  46. ↑ Anon (2009). "Langdale, Rachel" . Who's Who (online Oxford University Press  ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U249652.(Subscription or UK public library membership required.)
  47. ↑ "Rachel Langdale KC". 7br.co.uk.

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