ACOT12

ACOT12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B7K, 4MOB, 4MOC
Identifiers
Aliases	ACOT12 , CACH-1, Cach, STARD15, THEAL, acyl-CoA thioesterase 12
External IDs	OMIM: 614315 MGI: 1921406 HomoloGene: 12540 GeneCards: ACOT12
Gene location (Human)
Chr.	Chromosome 5 (human)
End	81,394,179 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	91,934,267 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney; ; duodenum; ; Achilles tendon; ; stromal cell of endometrium; ; hypothalamus; ; muscle tissue; ; sural nerve; ; placenta; ; amygdala;
	Top expressed in
	kidney; ; left lobe of liver; ; proximal tubule; ; jejunum; ; intestinal villus; ; duodenum; ; seminiferous tubule; ; skin of abdomen; ; sexually immature organism; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxylic ester hydrolase activity ; ATP binding ; hydrolase activity ; lipid binding ; acetyl-CoA hydrolase activity ; acyl-CoA hydrolase activity ; fatty-acyl-CoA binding ; palmitoyl-CoA hydrolase activity ; long-chain fatty acyl-CoA binding ; thiolester hydrolase activity ;
Cellular component	cytoplasm ; cytosol ;
Biological process	pyruvate metabolic process ; lipid metabolism ; acyl-CoA metabolic process ; acetyl-CoA metabolic process ; fatty acid metabolic process ; palmitic acid biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	134526
	74156
	ENSG00000172497
	ENSMUSG00000021620
	Q8WYK0
	Q9DBK0
	NM_130767
	NM_028790
	NP_570123
	NP_083066
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 23, 2023

Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene.^[5]^[6]^[7] The protein contains a StAR-related lipid transfer domain.

Related Research Articles

Thioesterases are enzymes which belong to the esterase family. Esterases, in turn, are one type of the several hydrolases known.

The enzyme choloyl-CoA hydrolase (EC 3.1.2.27) catalyzes the reaction

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.

Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene.

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating is an enzyme that in humans is encoded by the NSDHL gene. This enzyme is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis.

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.

Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene.

Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene.

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.

Acyl-coenzyme A thioesterase 4 is an enzyme that in humans is encoded by the ACOT4 gene.

Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene. This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates which relies on its StAR-related lipid transfer domain. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms.

Peroxisomal acyl-coenzyme A oxidase 3 is an enzyme that in humans is encoded by the ACOX3 gene.

Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene.

Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 gene

Acyl-CoA thioesterase 6 is a protein that in humans is encoded by the ACOT6 gene. The protein, also known as C14orf42, is an enzyme with thioesterase activity.

Acyl-CoA synthetase family member 3 is an enzyme that in humans is encoded by the ACSF3 gene.

Acyl-CoA thioesterase 9 is a protein that is encoded by the human ACOT9 gene. It is a member of the acyl-CoA thioesterase superfamily, which is a group of enzymes that hydrolyze Coenzyme A esters. There is no known function, however it has been shown to act as a long-chain thioesterase at low concentrations, and a short-chain thioesterase at high concentrations.

Acyl-CoA thioesterase 13 is a protein that in humans is encoded by the ACOT13 gene. This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation.

Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene.

Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172497 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021620 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi: 10.1194/jlr.E500003-JLR200 . PMID 16103133.
↑ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
↑ "Entrez Gene: ACOT12 acyl-CoA thioesterase 12".

External links

Human ACOT12 genome location and ACOT12 gene details page in the UCSC Genome Browser .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Acetyl-coenzyme A thioesterase

Suematsu N, Isohashi F (2007). "Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase". Acta Biochim. Pol. 53 (3): 553–61. doi: 10.18388/abp.2006_3327 . PMID 16951743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Suematsu N, Okamoto K, Isohashi F (2004). "Simple and unique purification by size-exclusion chromatography for an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A hydrolase". J. Chromatogr. B. 790 (1–2): 239–44. doi:10.1016/s1570-0232(03)00167-3. PMID 12767336.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Suematsu N, Okamoto K, Shibata K, et al. (2001). "Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase". Eur. J. Biochem. 268 (9): 2700–9. doi: 10.1046/j.1432-1327.2001.02162.x . PMID 11322891.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172497 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021620 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16103133-5] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi: 10.1194/jlr.E500003-JLR200 . PMID 16103133.

[pmid16940157-6] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.

[entrez-7] "Entrez Gene: ACOT12 acyl-CoA thioesterase 12".

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v t e Thioesterases (EC 3.1.2)
Acetyl-CoA thioesterases
Acyl-CoA thioesterases	ACOT1 ACOT2 ACOT4 ACOT6 ACOT7 ACOT8 ACOT9 ACOT11 ACOT12 ACOT13
Formyl-CoA thioesterases
Palmitoyl protein thioesterases	PPT1 PPT2
Succinyl-CoA thioesterases
Ubiquitin C-terminal hydrolases	UCHL1 UCHL3 UCHL5

ACOT12

Contents

Related Research Articles

References

External links

Further reading