Acetyl-CoA hydrolase

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acetyl-CoA hydrolase
Identifiers
EC no. 3.1.2.1
CAS no. 9027-54-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

The enzyme acetyl-CoA hydrolase (EC 3.1.2.1) catalyzes the reaction

Contents

Acetyl-CoA hydrolase.svg
acetyl-CoA + H2O CoA + acetate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is CoA thiol esterase. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2H4U.

See also

Related Research Articles

An esterase is a hydrolase enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis.

<span class="mw-page-title-main">Citrate synthase</span> Mammalian protein found in Homo sapiens

The enzyme citrate synthase E.C. 2.3.3.1 ] exists in nearly all living cells and stands as a pace-making enzyme in the first step of the citric acid cycle. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitochondrial matrix.

<span class="mw-page-title-main">Aspartoacylase</span> Hydrolytic enzyme encoded on human chromosome 17

Aspartoacylase is a hydrolytic enzyme that in humans is encoded by the ASPA gene. ASPA catalyzes the deacylation of N-acetyl-l-aspartate (N-acetylaspartate) into aspartate and acetate. It is a zinc-dependent hydrolase that promotes the deprotonation of water to use as a nucleophile in a mechanism analogous to many other zinc-dependent hydrolases. It is most commonly found in the brain, where it controls the levels of N-acetyl-l-aspartate. Mutations that result in loss of aspartoacylase activity are associated with Canavan disease, a rare autosomal recessive neurodegenerative disease.

The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction

The enzyme 6-acetylglucose deacetylase (EC 3.1.1.33) catalyzes the reaction

The enzyme [acetyl-CoA carboxylase]-phosphatase (EC 3.1.3.44) catalyzes the reaction

The enzyme alkylacetylglycerophosphatase (EC 3.1.3.59) catalyzes the reaction

The enzyme chondro-4-sulfatase (EC 3.1.6.9) catalyzes the reaction

The enzyme chondro-6-sulfatase (EC 3.1.6.10) catalyzes the reaction

The enzyme citrate lyase deacetylase (EC 3.1.2.16) catalyzes the reaction

The enzyme formyl-CoA hydrolase (EC 3.1.2.10) catalyzes the reaction

The enzyme N-acetylgalactosaminoglycan deacetylase (EC 3.1.1.58) catalyzes the reaction

The enzyme succinyl-CoA hydrolase (EC 3.1.2.3) catalyzes the reaction

In enzymology, a mucinaminylserine mucinaminidase (EC 3.2.1.110) is an enzyme that catalyzes the chemical reaction

In enzymology, an acetylornithine deacetylase (EC 3.5.1.16) is an enzyme that catalyzes the chemical reaction

In enzymology, a N-acetyldiaminopimelate deacetylase (EC 3.5.1.47) is an enzyme that catalyzes the chemical reaction

In enzymology, a (S)-N-acetyl-1-phenylethylamine hydrolase (EC 3.5.1.85) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">ACOT12</span> Protein-coding gene in the species Homo sapiens

Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene. The protein contains a StAR-related lipid transfer domain.

Endo-α-N-acetylgalactosaminidase (EC 3.2.1.97, endo-α-acetylgalactosaminidase, endo-α-N-acetyl-D-galactosaminidase, mucinaminylserine mucinaminidase, D-galactosyl-3-(N-acetyl-α-D-galactosaminyl)-L-serine mucinaminohydrolase, endo-α-GalNAc-ase, D-galactosyl-N-acetyl-α-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase) is an enzyme with systematic name glycopeptide-D-galactosyl-N-acetyl-α-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase. This enzyme catalyses the following chemical reaction

Acylaminoacyl-peptidase is an enzyme. This enzyme catalyses the following chemical reaction

References


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