ACOT8

Last updated

ACOT8
Identifiers
Aliases ACOT8 , HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE, NAP1, acyl-CoA thioesterase 8
External IDs OMIM: 608123; MGI: 2158201; HomoloGene: 3991; GeneCards: ACOT8; OMA:ACOT8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005469
NM_183385
NM_183386

NM_133240
NM_001362756
NM_001362757

RefSeq (protein)

NP_005460

NP_573503
NP_001349685
NP_001349686

Location (UCSC) Chr 20: 45.84 – 45.86 Mb Chr 2: 164.63 – 164.65 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene. [5] [6] [7] [8] [9]

Contents

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene. [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101473 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017307 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jones JM, Nau K, Geraghty MT, Erdmann R, Gould SJ (Apr 1999). "Identification of peroxisomal acyl-CoA thioesterases in yeast and humans". J Biol Chem. 274 (14): 9216–23. doi: 10.1074/jbc.274.14.9216 . PMID   10092594.
  6. Liu LX, Margottin F, Le Gall S, Schwartz O, Selig L, Benarous R, Benichou S (Jul 1997). "Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation". J Biol Chem. 272 (21): 13779–85. doi: 10.1074/jbc.272.21.13779 . PMID   9153233.
  7. Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi: 10.1194/jlr.E500003-JLR200 . PMID   16103133.
  8. Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs" . FASEB J. 20 (11): 1855–64. doi: 10.1096/fj.06-6042com . PMID   16940157. S2CID   501610.
  9. 1 2 "Entrez Gene: ACOT8 acyl-CoA thioesterase 8".

Further reading