UCHL3

UCHL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UCH, 1XD3
Identifiers
Aliases	UCHL3 , UCH-L3, ubiquitin C-terminal hydrolase L3
External IDs	OMIM: 603090; MGI: 1355274; HomoloGene: 4377; GeneCards: UCHL3; OMA:UCHL3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q22.2 Start 75,549,480 bp [1] End 75,606,020 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 E2.3|14 50.9 cM Start 101,891,403 bp [2] End 101,933,561 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland islet of Langerhans left adrenal cortex mucosa of esophagus rectum skin of leg gastrocnemius muscle skin of abdomen Top expressed in left ventricle interventricular septum spermatid epiblast embryo spermatocyte neural tube esophagus placenta mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cysteine-type peptidase activity hydrolase activity peptidase activity ubiquitin binding NEDD8-specific protease activity thiol-dependent deubiquitinase Cellular component nucleus intracellular anatomical structure cytoplasm cytosol Biological process protein catabolic process proteolysis ubiquitin-dependent protein catabolic process post-translational protein modification protein deubiquitination protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7347 50933 Ensembl ENSG00000118939 ENSMUSG00000022111 UniProt P15374 Q9JKB1 RefSeq (mRNA) NM_001270952 NM_006002 NM_016723 RefSeq (protein) NP_001257881 NP_005993 NP_057932 Location (UCSC) Chr 13: 75.55 – 75.61 Mb Chr 14: 101.89 – 101.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene. ^{[5] [6]}

Interactions

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1. ^{[7] [8]}

See also

• Ubiquitin carboxy-terminal hydrolase L1—an enzyme

References

1. GRCh38: Ensembl release 89: ENSG00000118939 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022111 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. Bibcode:1989Sci...246..670W. doi:10.1126/science.2530630. PMID   2530630.
6. "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)".
7. Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi: 10.1016/j.febslet.2011.06.037 . PMID   21762696. S2CID   28207136.
8. Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID   9790970.

Further reading

• Johnston SC, Larsen CN, Cook WJ, et al. (1997). "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution". EMBO J. 16 (13): 3787–96. doi:10.1093/emboj/16.13.3787. PMC   1170002 . PMID   9233788.
• Wilkinson KD, Laleli-Sahin E, Urbauer J, et al. (1999). "The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3". J. Mol. Biol. 291 (5): 1067–77. doi:10.1006/jmbi.1999.3038. PMID   10518943.
• Baek SH, Yoo YJ, Tanaka K, Chung CH (1999). "Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution". Biochem. Biophys. Res. Commun. 264 (1): 235–40. doi:10.1006/bbrc.1999.1492. PMID   10527871.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. doi: 10.1007/s10038-003-0021-7 . PMID   12721789.
• Nam MJ, Madoz-Gurpide J, Wang H, et al. (2004). "Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3". Proteomics. 3 (11): 2108–15. doi:10.1002/pmic.200300594. PMID   14595809. S2CID   27511690.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Misaghi S, Galardy PJ, Meester WJ, et al. (2005). "Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate". J. Biol. Chem. 280 (2): 1512–20. doi: 10.1074/jbc.M410770200 . PMID   15531586.
• Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID   16402389. S2CID   6633207.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.