PPT2

For the video game, see Puyo Puyo Tetris 2.

PPT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PJA
Identifiers
Aliases	PPT2 , C6orf8, G14, PPT-2, palmitoyl-protein thioesterase 2
External IDs	OMIM: 603298; MGI: 1860075; HomoloGene: 10448; GeneCards: PPT2; OMA:PPT2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.32 Start 32,153,441 bp [1] End 32,163,678 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B1|17 18.19 cM Start 34,835,636 bp [2] End 34,847,484 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary right hemisphere of cerebellum tibial nerve left uterine tube canal of the cervix body of uterus skin of leg vagina ectocervix Top expressed in otic placode right kidney proximal tubule saccule ankle external carotid artery human kidney otic vesicle internal carotid artery molar More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity thiolester hydrolase activity palmitoyl-(protein) hydrolase activity palmitoyl hydrolase activity Cellular component lysosome lysosomal lumen extracellular exosome intracellular membrane-bounded organelle integral component of membrane membrane Biological process macromolecule depalmitoylation fatty-acyl-CoA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9374 54397 Ensembl ENSG00000227600 ENSG00000231618 ENSG00000168452 ENSG00000228116 ENSG00000236649 ENSG00000206256 ENSG00000206329 ENSG00000221988 ENSMUSG00000015474 UniProt Q9UMR5 O35448 RefSeq (mRNA) NM_138934 NM_001204103 NM_005155 NM_138717 NM_019441 NM_001302393 NM_001302394 NM_001302395 NM_001302396 RefSeq (protein) NP_001191032 NP_005146 NP_619731 NP_001289322 NP_001289323 NP_001289324 NP_001289325 NP_062314 Location (UCSC) Chr 6: 32.15 – 32.16 Mb Chr 17: 34.84 – 34.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14, is an enzyme that in humans is encoded by the PPT2 gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the palmitoyl protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. ^[5]

References

1. ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 GRCh38: Ensembl release 89: ENSG00000227600, ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015474 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: palmitoyl-protein thioesterase 2".
6. Soyombo AA, Hofmann SL (October 1997). "Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity". J. Biol. Chem. 272 (43): 27456–63. doi: 10.1074/jbc.272.43.27456 . PMID   9341199.
7. Soyombo AA, Yi W, Hofmann SL (March 1999). "Structure of the human palmitoyl-protein thioesterase-2 gene (PPT2) in the major histocompatibility complex on chromosome 6p21.3". Genomics. 56 (2): 208–16. doi:10.1006/geno.1998.5703. PMID   10051407.

Further reading

• Gupta P, Soyombo AA, Atashband A, et al. (2001). "Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13566–71. Bibcode:2001PNAS...9813566G. doi: 10.1073/pnas.251485198 . PMC   61081 . PMID   11717424.
• Aguado B, Campbell RD (1999). "Characterization of a human MHC class III region gene product with S-thioesterase activity". Biochem. J. 341 ( Pt 3) (Pt 3): 679–89. doi:10.1042/bj3410679. PMC   1220406 . PMID   10417332.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Hancock DB, Eijgelsheim M, Wilk JB, et al. (2010). "Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function". Nat. Genet. 42 (1): 45–52. doi:10.1038/ng.500. PMC   2832852 . PMID   20010835.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Calero G, Gupta P, Nonato MC, et al. (2003). "The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2". J. Biol. Chem. 278 (39): 37957–64. doi: 10.1074/jbc.M301225200 . PMID   12855696.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Barcellos LF, May SL, Ramsay PP, et al. (2009). Roopenian DC (ed.). "High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions". PLOS Genet. 5 (10): e1000696. doi: 10.1371/journal.pgen.1000696 . PMC   2758598 . PMID   19851445.
• McKinnon E, Morahan G, Nolan D, et al. (2009). "Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach". Diabetes Obes Metab. 11 (Suppl 1): 92–100. doi:10.1111/j.1463-1326.2008.01009.x. PMC   2755510 . PMID   19143821.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Xie T, Rowen L, Aguado B, et al. (2003). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC   403804 . PMID   14656967.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Hillman RT, Green RE, Brenner SE (2004). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2) R8. doi: 10.1186/gb-2004-5-2-r8 . PMC   395752 . PMID   14759258.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.