ALDH1B1

ALDH1B1
Identifiers
Aliases	ALDH1B1 , ALDH5, ALDHX, aldehyde dehydrogenase 1 family member B1
External IDs	OMIM: 100670; MGI: 1919785; HomoloGene: 115470; GeneCards: ALDH1B1; OMA:ALDH1B1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p13.1 Start 38,392,702 bp [1] End 38,398,661 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B1 Start 45,799,022 bp [2] End 45,804,604 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell right coronary artery tendon of biceps brachii popliteal artery tibial arteries thoracic aorta ascending aorta Descending thoracic aorta left coronary artery left uterine tube Top expressed in crypt of lieberkuhn of small intestine epithelium of small intestine migratory enteric neural crest cell ileum jejunum duodenum left colon atrium intestinal villus Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity aldehyde dehydrogenase (NAD+) activity NAD binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Cellular component mitochondrial matrix intracellular membrane-bounded organelle mitochondrion nucleoplasm Biological process ethanol catabolic process metabolism ethanol oxidation carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 219 72535 Ensembl ENSG00000137124 ENSMUSG00000035561 UniProt P30837 Q9CZS1 RefSeq (mRNA) NM_000692 NM_028270 RefSeq (protein) NP_000683 NP_082546 Location (UCSC) Chr 9: 38.39 – 38.4 Mb Chr 4: 45.8 – 45.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Aldehyde dehydrogenase X, mitochondrial is an enzyme that in humans is encoded by the ALDH1B1 gene. ^{[5] [6]}

Function

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000137124 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035561 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hsu LC, Chang WC (Jul 1991). "Cloning and characterization of a new functional human aldehyde dehydrogenase gene". The Journal of Biological Chemistry. 266 (19): 12257–65. doi: 10.1016/S0021-9258(18)98890-3 . PMID   2061311.
6. "Entrez Gene: ALDH1B1 aldehyde dehydrogenase 1 family, member B1".

External links

• Human ALDH1B1 genome location and ALDH1B1 gene details page in the UCSC Genome Browser .

Further reading

• Yoshida A (Aug 1992). "Molecular genetics of human aldehyde dehydrogenase". Pharmacogenetics. 2 (4): 139–47. doi:10.1097/00008571-199208000-00001. PMID   1306115.
• Hiraoka LR, Hsu L, Hsieh CL (Jan 1995). "Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13". Genomics. 25 (1): 323–5. doi:10.1016/0888-7543(95)80150-K. PMID   7774944.
• Stewart MJ, Malek K, Xiao Q, Dipple KM, Crabb DW (Jun 1995). "The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme". Biochemical and Biophysical Research Communications. 211 (1): 144–51. doi:10.1006/bbrc.1995.1789. PMID   7779080.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Sherman D, Davé V, Hsu LC, Peters TJ, Yoshida A (Nov 1993). "Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene". Human Genetics. 92 (5): 477–80. doi:10.1007/BF00216454. PMID   8244338. S2CID   10507521.
• Stewart MJ, Malek K, Crabb DW (Feb 1996). "Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues". Journal of Investigative Medicine. 44 (2): 42–6. PMID   8689400.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Luo P, Wang A, Payne KJ, Peng H, Wang JG, Parrish YK, Rogerio JW, Triche TJ, He Q, Wu L (Oct 2007). "Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells". Stem Cells. 25 (10): 2628–37. doi: 10.1634/stemcells.2007-0264 . PMID   17628022. S2CID   20497224.