ALDH16A1

ALDH16A1
Identifiers
Aliases	ALDH16A1 , aldehyde dehydrogenase 16 family member A1
External IDs	OMIM: 613358 MGI: 1916998 HomoloGene: 34938 GeneCards: ALDH16A1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,471,050 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,804,008 bp
RNA expression pattern
	Top expressed in
	spleen; ; canal of the cervix; ; right lobe of liver; ; body of pancreas; ; Right adrenal gland; ; left uterine tube; ; Left adrenal gland; ; skin of abdomen; ; body of stomach; ; subcutaneous adipose tissue;
	Top expressed in
	duodenum; ; proximal tubule; ; jejunum; ; crypt of lieberkuhn of small intestine; ; interventricular septum; ; internal carotid artery; ; ileum; ; intestinal villus; ; Paneth cell; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity ; aldehyde dehydrogenase (NAD+) activity ; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ;
Cellular component	extracellular exosome ; membrane ;
Biological process	metabolism ;
	Sources:Amigo / QuickGO
Orthologs
	126133
	69748
	ENSG00000161618
	ENSMUSG00000007833
	Q8IZ83
	Q571I9
	NM_001145396 ; NM_153329
	NM_145954
	NP_001138868 ; NP_699160
	NP_666066
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

Aldehyde dehydrogenase 16 family, member A1 also known as ALDH16A1 is an aldehyde dehydrogenase gene.

Clinical significance

Mutations in the SPG21 (ACP33/maspardin) gene are associated with the mast syndrome, a type of spastic paraplegia. The protein encoded by the SPG21 gene has been shown to interact with the ALDH16A1 enzyme.^[5]

Related Research Articles

Aldehyde dehydrogenase, dimeric NADP-preferring is an enzyme that in humans is encoded by the ALDH3A1 gene.

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.

Protein FAM107A is a protein that in humans is encoded by the FAM107A gene.

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ALDH4A1 gene.

BTB/POZ domain-containing protein KCTD12 is a protein that in humans is encoded by the KCTD12 gene.

Vacuolar protein sorting-associated protein VTA1 homolog is a protein that in humans is encoded by the VTA1 gene.

Mitochondrial dynamic protein MID51 (MID51) also known as mitochondrial elongation factor 1 (MIEF1) or Smith-Magenis syndrome chromosome region candidate gene 7 protein-like (SMCR7L) is a protein that in humans is encoded by the SMCR7L gene.

Aldehyde dehydrogenase 1 family, member A2, also known as ALDH1A2 or retinaldehyde dehydrogenase 2 (RALDH2), is an enzyme that in humans is encoded by the ALDH1A2 gene.

Dehydrogenase/reductase SDR family member 1, also known as Short chain dehydrogenase/reductase family 19C member 1 is an enzyme that in humans is encoded by the DHRS1 gene located on chromosome 14.

KIAA0930 is a protein that, in humans, is encoded by the KIAA0930 gene.

Syntenin-2 is a protein that in humans is encoded by the SDCBP2 gene.

Maspardin is a protein that in humans is encoded by the SPG21 gene.

Vacuolar protein sorting-associated protein 13D is a protein that in humans is encoded by the VPS13D gene.

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.

RING finger protein 13 is a protein that in humans is encoded by the RNF13 gene.

Aldehyde dehydrogenase family 3 member B2 is an enzyme that in humans is encoded by the ALDH3B2 gene.

RNA-binding Raly-like protein is a protein that in humans is encoded by the RALYL gene.

Aldehyde dehydrogenase 1 family, member L2 also known as ALDH1L2 is an enzyme that in humans is encoded by the ALDH1L2 gene. ALDH1L2 is the mitochondrial isoform of a similar enzyme, ALDH1L1, which converts 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.

Aldehyde dehydrogenase 1 family, member A3, also known as ALDH1A3 or retinaldehyde dehydrogenase 3 (RALDH3), is an enzyme that in humans is encoded by the ALDH1A3 gene,

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000161618 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007833 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hanna MC, Blackstone C (January 2009). "Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1". Neurogenetics. 10 (3): 217–28. doi:10.1007/s10048-009-0172-6. PMC 5585778 . PMID 19184135.

External links

Human ALDH16A1 genome location and ALDH16A1 gene details page in the UCSC Genome Browser .

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422 . PMID 19615732.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000161618 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007833 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid19184135-5] Hanna MC, Blackstone C (January 2009). "Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1". Neurogenetics. 10 (3): 217–28. doi:10.1007/s10048-009-0172-6. PMC 5585778 . PMID 19184135.

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v t e Aldehyde dehydrogenases (EC 1.2.1)
Family 1	Retinaldehyde — ALDH1A1 ALDH1A2 ALDH1A3 ALDH1B1 Formyltetrahydrofolate — ALDH1L1 ALDH1L2
Family 2 (mitochondrial)	ALDH2
Family 3	Dimeric NADP-preferring — (ALDH3A1) Fatty aldehyde — (ALDH3A2) ALDH3B1 ALDH3B2
Other	ALDH4A1 ALDH5A1 ALDH6A1 α-Aminoadipic semialdehyde — (ALDH7A1) ALDH8A1 ALDH9A1 ALDH16A1 ALDH18A1 Glyceraldehyde 3-phosphate — (GAPDH)

ALDH16A1

Contents

Clinical significance

Related Research Articles

References

External links

Further reading