ALDH3B1

ALDH3B1
Identifiers
Aliases	ALDH3B1 , ALDH4, ALDH7, aldehyde dehydrogenase 3 family member B1
External IDs	OMIM: 600466; MGI: 1914939; HomoloGene: 73890; GeneCards: ALDH3B1; OMA:ALDH3B1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.2 Start 68,008,578 bp [1] End 68,029,282 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 3,963,491 bp [2] End 3,979,808 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right uterine tube olfactory zone of nasal mucosa nasal epithelium monocyte right lung mucosa of paranasal sinus granulocyte thoracic diaphragm beta cell Top expressed in granulocyte spermatid Epithelium of choroid plexus right kidney right lung lobe stroma of bone marrow duodenum tibiofemoral joint seminiferous tubule jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function 3-chloroallyl aldehyde dehydrogenase activity protein binding oxidoreductase activity aldehyde dehydrogenase [NAD(P)+ activity] aldehyde dehydrogenase (NAD+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Cellular component vesicle membrane plasma membrane extracellular exosome secretory granule membrane specific granule membrane cytoplasm cytosol Biological process ethanol catabolic process lipid metabolism aldehyde catabolic process sphingolipid biosynthetic process cellular aldehyde metabolic process cellular response to oxidative stress metabolism alcohol metabolic process neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221 67689 Ensembl ENSG00000006534 ENSMUSG00000024885 UniProt P43353 Q9BUJ8 Q80VQ0 RefSeq (mRNA) NM_001290059 NM_000694 NM_001030010 NM_001161473 NM_001290058 NM_026316 RefSeq (protein) NP_000685 NP_001025181 NP_001154945 NP_001276987 NP_001276988 NP_080592 Location (UCSC) Chr 11: 68.01 – 68.03 Mb Chr 19: 3.96 – 3.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Aldehyde dehydrogenase 3 family, member B1 also known as ALDH3B1 is an enzyme that in humans is encoded by the ALDH3B1 gene. ^{[5] [6]}

Function

The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene encodes a single transcript of 2.8 kb that is highly expressed in kidney and lung. The functional significance of this gene and the cellular localization of its product are presently unknown. Two transcript variants encoding different isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000006534 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024885 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hsu LC, Chang WC, Yoshida A (Dec 1994). "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene. 151 (1–2): 285–9. doi:10.1016/0378-1119(94)90672-6. PMID   7828891.
6. Hsu LC, Chang WC, Yoshida A (Apr 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID   9161417.
7. "Entrez Gene: ALDH3B1".

External links

• Human ALDH3B1 genome location and ALDH3B1 gene details page in the UCSC Genome Browser .

Further reading

• Sun X, Jia Y, Zhang X, Xu Q, Shen Y, Li Y (Jun 2005). "Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method". Science in China Series C: Life Sciences. 48 (3): 263–9. doi:10.1007/bf03183620. PMID   16092759. S2CID   19136391.
• Hsu LC, Chang WC, Yoshida A (Dec 1994). "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene. 151 (1–2): 285–9. doi:10.1016/0378-1119(94)90672-6. PMID   7828891.
• Marchitti SA, Orlicky DJ, Vasiliou V (May 2007). "Expression and initial characterization of human ALDH3B1". Biochemical and Biophysical Research Communications. 356 (3): 792–8. doi:10.1016/j.bbrc.2007.03.046. PMC   1899873 . PMID   17382292.
• Saito A, Kawamoto M, Kamatani N (Jun 2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". Journal of Human Genetics. 54 (6): 317–23. doi: 10.1038/jhg.2009.31 . PMID   19343046.
• Wang Y, Hu Y, Fang Y, Zhang K, Yang H, Ma J, Xu Q, Shen Y (Jun 2009). "Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia". Biological Psychiatry. 65 (12): 1048–54. doi:10.1016/j.biopsych.2008.11.027. PMID   19159868. S2CID   25166866.
• Yoshida A, Rzhetsky A, Hsu LC, Chang C (Feb 1998). "Human aldehyde dehydrogenase gene family". European Journal of Biochemistry. 251 (3): 549–57. doi: 10.1046/j.1432-1327.1998.2510549.x . PMID   9490025.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.