ALDH1L1

Last updated
ALDH1L1
Protein ALDH1L1 PDB 1s3i.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ALDH1L1 , 10-FTHFDH, 10-fTHF, FDH, FTHFD, aldehyde dehydrogenase 1 family member L1
External IDs OMIM: 600249 MGI: 1340024 HomoloGene: 122031 GeneCards: ALDH1L1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270364
NM_001270365
NM_012190
NM_144776

NM_027406
NM_001356412

RefSeq (protein)

NP_001257293
NP_001257294
NP_036322

NP_081682
NP_001343341

Location (UCSC) Chr 3: 126.1 – 126.2 Mb Chr 6: 90.46 – 90.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene. [5]

Contents

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning. [5]

Related Research Articles

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<span class="mw-page-title-main">MTHFD1</span>

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NAD-dependent methylenetetrahydrofolate dehydrogenase 2-like protein (MTHFD2L), also known as bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, is an enzyme that in humans is encoded by the MTHFD2L gene on chromosome 4. This enzyme localizes to the inner mitochondrial membrane, where it performs the NADP+-dependent dehydrogenase/cyclohydrolase activity as part of the mitochondrial pathway to convert folate to formate. It is associated with fluctuations in cytokine secretion in response to viral infections and vaccines.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144908 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030088 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: ALDH1L1 aldehyde dehydrogenase 1 family, member L1".

Further reading