ALDH3B2

ALDH3B2
Identifiers
Aliases	ALDH3B2 , ALDH8, aldehyde dehydrogenase 3 family member B2
External IDs	OMIM: 601917 GeneCards: ALDH3B2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.2 Start 67,662,155 bp [1] End 67,681,224 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vulva skin of abdomen cavity of mouth parotid gland human penis nipple vagina hair follicle thymus minor salivary gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3-chloroallyl aldehyde dehydrogenase activity oxidoreductase activity aldehyde dehydrogenase [NAD(P)+ activity] oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Cellular component lipid droplet Biological process ethanol catabolic process metabolism alcohol metabolic process lipid metabolism sphingolipid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 222 n/a Ensembl ENSG00000132746 n/a UniProt P48448 n/a RefSeq (mRNA) NM_000695 NM_001031615 NM_001354345 NM_001393400 NM_001393401 NM_001393402 n/a RefSeq (protein) NP_000686 NP_001026786 NP_001341274 n/a Location (UCSC) Chr 11: 67.66 – 67.68 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Aldehyde dehydrogenase family 3 member B2 is an enzyme that in humans is encoded by the ALDH3B2 gene. ^{[3] [4] [5]}

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000132746 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hsu LC, Chang WC (Dec 1996). "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family". Gene. 174 (2): 319–22. doi:10.1016/0378-1119(96)00087-X. PMID   8890755.
4. Hsu LC, Chang WC, Yoshida A (Jun 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID   9161417.
5. "Entrez Gene: ALDH3B2 aldehyde dehydrogenase 3 family, member B2".

External links

• Human ALDH3B2 genome location and ALDH3B2 gene details page in the UCSC Genome Browser .

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Hsu LC, Chang WC, Lin SW, Yoshida A (1995). "Cloning and Characterization of Genes Encoding Four Additional Human Aldehyde Dehydrogenase Isozymes". Enzymology and Molecular Biology of Carbonyl Metabolism 5. Advances in Experimental Medicine and Biology. Vol. 372. pp. 159–68. doi:10.1007/978-1-4615-1965-2_21. ISBN   978-1-4613-5808-4. PMID   7484374.