Adenosine nucleosidase

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adenosine nucleosidase
Identifiers
EC no. 3.2.2.7
CAS no. 9075-41-6
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ExPASy NiceZyme view
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MetaCyc metabolic pathway
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In enzymology, an adenosine nucleosidase (EC 3.2.2.7) is an enzyme that catalyzes the chemical reaction

adenosine + H2O D-ribose + adenine

Thus, the two substrates of this enzyme are adenosine and H2O, whereas its two products are D-ribose and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is adenosine ribohydrolase. Other names in common use include adenosinase, N-ribosyladenine ribohydrolase, adenosine hydrolase, and ANase. This enzyme participates in purine metabolism.

Related Research Articles

<span class="mw-page-title-main">Ribonucleotide</span> Nucleotide containing ribose as its pentose component

In biochemistry, a ribonucleotide is a nucleotide containing ribose as its pentose component. It is considered a molecular precursor of nucleic acids. Nucleotides are the basic building blocks of DNA and RNA. Ribonucleotides themselves are basic monomeric building blocks for RNA. Deoxyribonucleotides, formed by reducing ribonucleotides with the enzyme ribonucleotide reductase (RNR), are essential building blocks for DNA. There are several differences between DNA deoxyribonucleotides and RNA ribonucleotides. Successive nucleotides are linked together via phosphodiester bonds.

<span class="mw-page-title-main">Adenosine diphosphate ribose</span> Chemical compound

Adenosine diphosphate ribose (ADPR) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD+) as a cofactor.

Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms.

<span class="mw-page-title-main">Nucleoside-diphosphatase</span> Group of proteins having nucleoside-diphosphatase activity

In enzymology, a nucleoside-diphosphatase (EC 3.6.1.6) is an enzyme that catalyzes the chemical reaction

In enzymology, a 1-methyladenosine nucleosidase (EC 3.2.2.13) is an enzyme that catalyzes the chemical reaction

In enzymology, an adenosylhomocysteine nucleosidase (EC 3.2.2.9) is an enzyme that catalyzes the chemical reaction

In enzymology, an AMP nucleosidase (EC 3.2.2.4) is an enzyme that catalyzes the chemical reaction

In enzymology, an inosinate nucleosidase (EC 3.2.2.12) is an enzyme that catalyzes the chemical reaction

In enzymology, an inosine nucleosidase (EC 3.2.2.2) is an enzyme that catalyzes the chemical reaction

In enzymology, a methylthioadenosine nucleosidase (EC 3.2.2.16) is an enzyme that catalyzes the chemical reaction

In enzymology, a NAD+ glycohydrolase (EC 3.2.2.5) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">ADP-ribosyl cyclase</span>

In enzymology, a ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) is a bifunctional enzyme that catalyzes the chemical reaction

In enzymology, a N-methyl nucleosidase (EC 3.2.2.25) is an enzyme that catalyzes the chemical reaction

In enzymology, a NMN nucleosidase (EC 3.2.2.14) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Purine nucleosidase</span>

In enzymology, a purine nucleosidase (EC 3.2.2.1) is an enzyme that catalyzes the chemical reaction

In enzymology, a pyrimidine-5'-nucleotide nucleosidase (EC 3.2.2.10) is an enzyme that catalyzes the chemical reaction

In enzymology, a ribosylpyrimidine nucleosidase (EC 3.2.2.8) is an enzyme that catalyzes the chemical reaction

In enzymology, an uridine nucleosidase (EC 3.2.2.3) is an enzyme that catalyzes the chemical reaction

In enzymology, an adenosine-phosphate deaminase (EC 3.5.4.17) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Ribose</span> Group of simple sugar and carbohydrate compounds

Ribose is a simple sugar and carbohydrate with molecular formula C5H10O5 and the linear-form composition H−(C=O)−(CHOH)4−H. The naturally-occurring form, d-ribose, is a component of the ribonucleotides from which RNA is built, and so this compound is necessary for coding, decoding, regulation and expression of genes. It has a structural analog, deoxyribose, which is a similarly essential component of DNA. l-ribose is an unnatural sugar that was first prepared by Emil Fischer and Oscar Piloty in 1891. It was not until 1909 that Phoebus Levene and Walter Jacobs recognised that d-ribose was a natural product, the enantiomer of Fischer and Piloty's product, and an essential component of nucleic acids. Fischer chose the name "ribose" as it is a partial rearrangement of the name of another sugar, arabinose, of which ribose is an epimer at the 2' carbon; both names also relate to gum arabic, from which arabinose was first isolated and from which they prepared l-ribose.

References


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