Aloe emodin

Last updated
Aloe emodin
Aloe emodin.svg
Clinical data
Other namesRhabarberone
Routes of
administration
Oral
ATC code
  • None
Identifiers
  • 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.006.884 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C15H10O5
Molar mass 270.240 g·mol−1
3D model (JSmol)
Melting point 223 to 224 °C (433 to 435 °F) Sublimes in CO2 stream
  • O=C2c1cccc(O)c1C(=O)c3c2cc(cc3O)CO
  • InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2 Yes check.svgY
  • Key:YDQWDHRMZQUTBA-UHFFFAOYSA-N Yes check.svgY
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Aloe emodin (1,8-dihydroxy-3-(hydroxymethyl)anthraquinone) is an anthraquinone and an isomer of emodin present in aloe latex, an exudate from the aloe plant. It has a strong stimulant-laxative action. [1] Aloe emodin is not carcinogenic when applied to the skin, although it may increase the carcinogenicity of some kinds of radiation. [2] [3]

Aloe emodin is found in the gel, sap or leaves of aloe vera, the socotrine aloe, Barbados aloe, and Zanzibar aloes, the bark of Frangula ( Rhamnus frangula ) and cascara sagrada ( Rhamnus purshiana ), the leaves of Senna ( Cassia angustifolia ), and the rhizome of rhubarb ( Rheum rhaponticum ).[ citation needed ] Aloe-emodin has not been found in Natal aloes.[ citation needed ]

References

  1. The Merck Index (12th ed.). p. 313.
  2. Badgwell DB, Walker CM, Baker WT, Strickland FM (March 2004). "Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors". Molecular Carcinogenesis. 39 (3): 127–38. doi:10.1002/mc.10170. PMID   14991742. S2CID   24146785.
  3. National Toxicology Program (September 2010). "Photocarcinogenesis study of aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 mice (simulated solar light and topical application study)". National Toxicology Program Technical Report Series (553): 7–33, 35–97, 99–103 passim. PMID   21031007.

See also