Andres M. Lozano

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Andres M. Lozano is a Spanish-Canadian neurosurgeon and scientist known for [1] his work in Deep Brain Stimulation [2] and MR guided Focused Ultrasound Surgery. He holds the Alan & Susan Hudson Cornerstone Chair in Neurosurgery at the University Health Network Toronto and is a University Professor at the University of Toronto. [3] His work has been covered by major international news publications including BBC, [4] Scientific American, [5] The Independent, [6] The Globe and Mail [7] and NPR. [8]

Contents

Early Life and Education

Andres Lozano was born in Sevilla, Spain, and moved to Canada at a young age. He completed his B.Sc in Cell Biology and his M.D. at the University of Ottawa in 1983. He then pursued a Ph.D. in Neurobiology at McGill University, graduating in 1989. Lozano completed his neurosurgical training, earning his FRCS(C) in 1990, and became a diplomate of the American Board of Neurological Surgery in 1994.

Career

Dr. Lozano's career has been centered at the University of Toronto, [9] where he has held several positions, including the Dan Family Chairman of Neurosurgery (2010–2020) and the RR Tasker Chair in Functional Neurosurgery (1999–2021). He has also been a Canadian Research Chair in Neuroscience and an active staff member at the University Health Network since 1991.

Research and Contributions

Lozano has contributed extensively to the development and application of Deep Brain Stimulation and Focused Ultrasound Surgery for various neurological disorders, including Parkinson's disease, dystonia, depression, and Alzheimer's disease. [10] His research has resulted in over 830 publications with an h-index above 145, [11] ranking him among the most highly cited neurosurgeons globally according to Clarivate. [12] [13]

His team's work has included the mapping of cortical and subcortical circuits and the development of novel therapies. Lozano has led several "first in man" trials, including DBS applications for conditions like Huntington's disease and anorexia. Together with Helen Mayberg, in 2005, he published on the first human DBS for depression trial in the modern-era of DBS, [14] targeting Brodman area 25, which has led to multiple completed and ongoing clinical trials for DBS for depression, globally. [15] In 2010, he led the first pilot trial for human DBS in Alzheimer's disease trial targeting the Fornix region, which has led to multiple clinical trials, as well [10]

Honors and Awards

He has also been named one of Thomson Reuters' Highly Cited Researchers program and Most Influential Scientific Minds annually from 2015 to 2022.

Editorial and Professional Roles

Lozano serves as the Editor-in-Chief of Stereotactic and Functional Neurosurgery. [23] He has been a founding member of several research organizations, including the Michael J. Fox Foundation and the Weston Foundation.

Selected Publications

Some of Dr. Lozano's publications in recent years include:

Related Research Articles

<span class="mw-page-title-main">Deep brain stimulation</span> Neurosurgical treatment

Deep brain stimulation (DBS) is a surgical procedure that implants a neurostimulator and electrodes which sends electrical impulses to specified targets in the brain responsible for movement control. The treatment is designed for a range of movement disorders such as Parkinson's disease, essential tremor, and dystonia, as well as for certain neuropsychiatric conditions like obsessive-compulsive disorder (OCD) and epilepsy. The exact mechanisms of DBS are complex and not entirely clear, but it is known to modify brain activity in a structured way.

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Helen S. Mayberg, is an American neurologist. Mayberg is known in particular for her work delineating abnormal brain function in patients with major depression using functional neuroimaging. This work led to the first pilot study of deep brain stimulation (DBS), a reversible method of selective modulation of a specific brain circuit, for patients with treatment-resistant depression. As of August 2019, she has published 211 original peer-reviewed articles, 31 books and book chapters, and acted as principal investigator on 24 research grants. Mayberg is coinventor with Andres Lozano of “Method for Treating Depression Mood Disorders and Anxiety Disorders using Neuromodulation,” US patent 2005/0033379A1. St. Jude Medical Neuromodulation licensed her intellectual property to develop Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Unipolar and Bipolar Depression for the treatment of severe depression. As of 2018, Mayberg holds positions as Professor of Neurology and Neurosurgery and Professor, Psychiatry and Neuroscience, both at Mount Sinai Medical School, and Professor of Psychiatry, Emory University; Emory University Hospital. Since 2018, she has served as Director, Nash Family Center for Advanced Circuit Therapeutics at the Icahn School of Medicine at Mount Sinai.

Ablative brain surgery is the surgical ablation by various methods of brain tissue to treat neurological or psychological disorders. The word "Ablation" stems from the Latin word Ablatus meaning "carried away". In most cases, however, ablative brain surgery does not involve removing brain tissue, but rather destroying tissue and leaving it in place. The lesions it causes are irreversible. There are some target nuclei for ablative surgery and deep brain stimulation. Those nuclei are the motor thalamus, the globus pallidus, and the subthalamic nucleus.

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References

  1. ↑ "Article covering Lozano's work by The Independent". Independent.co.uk . 30 January 2008.
  2. ↑ "Deep Brain Stimulation". Stanford Parkinson's Community Outreach. Retrieved 2024-07-03.
  3. ↑ "Andres Lozano – Temerty Faculty of Medicine Awards 2023". medicineawards.utoronto.ca. Retrieved 2024-07-12.
  4. ↑ "Deep stimulation 'boosts memory'". 2008-01-30. Retrieved 2024-07-12.
  5. ↑ Mayberg, Andres M. Lozano, Helen S. (2015-02-01). "An Electrode in the Brain Turns Off Depression". Scientific American. Retrieved 2024-07-12.{{cite web}}: CS1 maint: multiple names: authors list (link)
  6. ↑ "Scientists discover way to reverse loss of memory". The Independent. 2008-01-30. Retrieved 2024-07-12.
  7. ↑ "How burning a hole in the brain eliminates a patient's shaking". The Globe and Mail. 2012-12-18. Retrieved 2024-07-12.
  8. ↑ "Reviving Memory With An Electrical Current". NPR.
  9. ↑ "University Toronto".
  10. 1 2 Stetka, Bret (May 14, 2016). "Reviving Memory With An Electrical Current". NPR.
  11. ↑ "am lozano". scholar.google.com. Retrieved 2024-07-03.
  12. ↑ "Web of Science". www.webofscience.com. Retrieved 2024-07-03.
  13. ↑ "Andres Lozano, MD, PhD | Parkinson's Disease". www.michaeljfox.org. Retrieved 2024-07-03.
  14. ↑ Price, Michael (2009-03-01). "SCIENCE WATCH: A pacemaker for your brain?". apa.org. Retrieved 2024-08-05.
  15. ↑ Segal, Dr Sanjay Gupta,Andy (2012-04-14). "Treating depression with electrodes inside the brain". CNN. Retrieved 2024-07-04.{{cite web}}: CS1 maint: multiple names: authors list (link)
  16. ↑ communications@parkinson.ca (2010-06-01). "Donald Calne Lecture". Parkinson Canada. Retrieved 2024-07-03.
  17. ↑ "Past Winn Prize Recipients - societyns.org". www.societyns.org. Retrieved 2024-07-03.
  18. ↑ "Andres Lozano - Society for Brain Mapping and Therapeutics". 2023-06-10. Retrieved 2024-07-03.
  19. ↑ "Olivecrona Awards Website".
  20. ↑ "Margolese National Brain Disorders Prize". UBC Faculty of Medicine. Retrieved 2024-07-03.
  21. ↑ joel (2016-12-20). "TD Bank's 10 Most Influential Hispanic Canadians - 2016". ILAC. Retrieved 2024-07-03.
  22. ↑ "Research.com".
  23. ↑ "Stereotactic and Functional Neurosurgery Website".
  24. ↑ Lozano, Andres M.; Lipsman, Nir; Bergman, Hagai; Brown, Peter; Chabardes, Stephan; Chang, Jin Woo; Matthews, Keith; McIntyre, Cameron C.; Schlaepfer, Thomas E.; Schulder, Michael; Temel, Yasin; Volkmann, Jens; Krauss, Joachim K. (March 2019). "Nature.com". Nature Reviews Neurology. 15 (3): 148–160. doi:10.1038/s41582-018-0128-2. PMC   6397644 . PMID   30683913.
  25. ↑ Jakobs, M.; Fomenko, A.; Lozano, A. M.; Kiening, K. L. (2019). "Embo Press". EMBO Molecular Medicine. 11 (4). doi:10.15252/emmm.201809575. PMC   6460356 . PMID   30862663.
  26. ↑ Deeb, Wissam; Salvato, Bryan; Almeida, Leonardo; Foote, Kelly D.; Amaral, Robert; Germann, Jurgen; Rosenberg, Paul B.; Tang-Wai, David F.; Wolk, David A.; Burke, Anna D.; Salloway, Stephen; Sabbagh, Marwan N.; Chakravarty, M. Mallar; Smith, Gwenn S.; Lyketsos, Constantine G.; Lozano, Andres M.; Okun, Michael S. (22 August 2019). "NEJM". New England Journal of Medicine. 381 (8): 783–785. doi:10.1056/NEJMc1905240. PMC   7313538 . PMID   31433930.
  27. ↑ "The Lancet".
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