Babesia canis

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Babesia canis
Babesia-canis-dog.jpg
Babesia canis piroplasm stage infecting red blood cells of a dog. Giemsa stained.
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Clade: Diaphoretickes
Clade: SAR
Clade: Alveolata
Phylum: Apicomplexa
Class: Aconoidasida
Order: Piroplasmida
Family: Babesiidae
Genus: Babesia
Species:
B. canis
Binomial name
Babesia canis
Synonyms

Piroplasma canis

Babesia canis is a parasite that infects red blood cells and can lead to anemia. [1] This is a species that falls under the overarching genus Babesia . It is transmitted by the brown dog tick ( Rhipicephalus sanguineus ) and is one of the most common piroplasm infections. [2] The brown dog tick is adapted to warmer climates and is found in both Europe and the United States, especially in shelters and greyhound kennels. [2] [3] In Europe, it is also transmitted by Dermacentor ticks with an increase in infections reported due to people traveling with their pets. [4]

Contents

Lifecycle

A tick carrying B. canis sporozoites attaches to a dog, and feeds on its blood, releasing many sporozoites into the dog's bloodstream. Each sporozoite attaches to a red blood cell, and moves inside the cell. Once inside the cell, the sporozoite loses its outer coating. It divides, becoming a new form, known as a merozoite. [5] Inside the tick, the merozoite undergoes sexual reproduction (gamogony), which is followed by asexual reproduction, resulting in many sporozoites. These are found in the tick salivary glands, and they move from there into the next dog on which the tick feeds. [6] Pregnant dogs can transmit B. canis to their unborn puppies, so infected females should not be bred. [7]

Symptoms, diagnosis, and treatment

The clinical signs of B. canis infection are lethargy, weakness, vomiting, anorexia, fever, pale mucous membranes, and dark discoloration of the urine. [8] Other symptoms may present, including neurological and respiratory signs.[ citation needed ]

B. canis is not easy to diagnose on a blood smear, since the chance of finding the parasite is low, due to its small size. Taking blood from a capillary source (such as a fresh cut) rather than from a blood vessel increases the chances of finding the organism.[ citation needed ] Polymerase chain reaction testing is a more accurate diagnostic method. [5]

B. canis infection in dogs usually responds to treatment with imidocarb dipropionate, although the infection may not be eliminated and dogs can become permanent carriers. [6] In dogs infected with B. canis, splenectomy (removal of the spleen) or any immunosuppressive drug should be avoided; otherwise, signs of babesiosis may recur. [6]

Prevention

Vaccines to prevent B. canis are not available in North America,[ citation needed ] but in France, a vaccine is available, although it only seems effective against certain strains. [5] The best prevention is tick control, or prompt removal of ticks from the dog. [6] The spread of B. canis by blood donation can be prevented by screening potential donor dogs for B. canis infection prior to their donation. [6]

See also

Related Research Articles

Ehrlichiosis is a tick-borne disease of dogs usually caused by the rickettsial agent Ehrlichia canis. Ehrlichia canis is the pathogen of animals. Humans can become infected by E. canis and other species after tick exposure. German Shepherd Dogs are thought to be susceptible to a particularly severe form of the disease; other breeds generally have milder clinical signs. Cats can also be infected.

<span class="mw-page-title-main">Babesiosis</span> Malaria-like parasitic disease caused by infection with the alveoate Babesia or Theileria

Babesiosis or piroplasmosis is a malaria-like parasitic disease caused by infection with a eukaryotic parasite in the order Piroplasmida, typically a Babesia or Theileria, in the phylum Apicomplexa. Human babesiosis transmission via tick bite is most common in the Northeastern and Midwestern United States and parts of Europe, and sporadic throughout the rest of the world. It occurs in warm weather. People can get infected with Babesia parasites by the bite of an infected tick, by getting a blood transfusion from an infected donor of blood products, or by congenital transmission . Ticks transmit the human strain of babesiosis, so it often presents with other tick-borne illnesses such as Lyme disease. After trypanosomes, Babesia is thought to be the second-most common blood parasite of mammals. They can have major adverse effects on the health of domestic animals in areas without severe winters. In cattle, the disease is known as Texas cattle fever or redwater.

<i>Plasmodium falciparum</i> Protozoan species of malaria parasite

Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease's most dangerous form, falciparum malaria. It is responsible for around 50% of all malaria cases. P. falciparum is therefore regarded as the deadliest parasite in humans. It is also associated with the development of blood cancer and is classified as a Group 2A (probable) carcinogen.

<span class="mw-page-title-main">Coccidia</span> Subclass of protists

Coccidia (Coccidiasina) are a subclass of microscopic, spore-forming, single-celled obligate intracellular parasites belonging to the apicomplexan class Conoidasida. As obligate intracellular parasites, they must live and reproduce within an animal cell. Coccidian parasites infect the intestinal tracts of animals, and are the largest group of apicomplexan protozoa.

<i>Hepatozoon</i> Genus of single-celled organisms

Hepatozoon is a genus of Apicomplexa alveolates which incorporates over 300 species of obligate intraerythrocytic parasites. Species have been described from all groups of tetrapod vertebrates, as well as a wide range of haematophagous arthropods, which serve as both the vectors and definitive hosts of the parasite. By far the most biodiverse and prevalent of all haemogregarines, the genus is distinguished by its unique reciprocal trophic lifecycle which lacks the salivary transmission between hosts commonly associated with other apicomplexans. While particularly prevalent in amphibians and reptiles, the genus is more well known in veterinary circles for causing a tick-borne disease called hepatozoonosis in some mammals.

<i>Plasmodium knowlesi</i> Species of single-celled organism

Plasmodium knowlesi is a parasite that causes malaria in humans and other primates. It is found throughout Southeast Asia, and is the most common cause of human malaria in Malaysia. Like other Plasmodium species, P. knowlesi has a life cycle that requires infection of both a mosquito and a warm-blooded host. While the natural warm-blooded hosts of P. knowlesi are likely various Old World monkeys, humans can be infected by P. knowlesi if they are fed upon by infected mosquitoes. P. knowlesi is a eukaryote in the phylum Apicomplexa, genus Plasmodium, and subgenus Plasmodium. It is most closely related to the human parasite Plasmodium vivax as well as other Plasmodium species that infect non-human primates.

<i>Babesia</i> Genus of protozoan parasites

Babesia, also called Nuttallia, is an apicomplexan parasite that infects red blood cells and is transmitted by ticks. Originally discovered by the Romanian bacteriologist Victor Babeș in 1888, over 100 species of Babesia have since been identified.

A canine vector-borne disease (CVBD) is one of "a group of globally distributed and rapidly spreading illnesses that are caused by a range of pathogens transmitted by arthropods including ticks, fleas, mosquitoes and phlebotomine sandflies." CVBDs are important in the fields of veterinary medicine, animal welfare, and public health. Some CVBDs are of zoonotic concern.

<span class="mw-page-title-main">Anaplasmosis</span> Medical condition

Anaplasmosis is a tick-borne disease affecting ruminants, dogs, and horses, and is caused by Anaplasma bacteria. Anaplasmosis is an infectious but not contagious disease. Anaplasmosis can be transmitted through mechanical and biological vector processes. Anaplasmosis can also be referred to as "yellow bag" or "yellow fever" because the infected animal can develop a jaundiced look. Other signs of infection include weight loss, diarrhea, paleness of the skin, aggressive behavior, and high fever.

<span class="mw-page-title-main">Ehrlichiosis</span> Medical condition

Ehrlichiosis is a tick-borne bacterial infection, caused by bacteria of the family Anaplasmataceae, genera Ehrlichia and Anaplasma. These obligate intracellular bacteria infect and kill white blood cells.

<i>Theileria</i> Genus of single-celled organisms

Theileria is a genus of parasites that belongs to the phylum Apicomplexa, and is closely related to Plasmodium. Two Theileria species, T. annulata and T. parva, are important cattle parasites. T. annulata causes tropical theileriosis and T. parva causes East Coast fever. Theileria species are transmitted by ticks. The genomes of T. orientalis Shintoku, Theileria equi WA, Theileria annulata Ankara and Theileria parva Muguga have been sequenced and published.

<i>Babesia microti</i> Species of parasitic protist in the Apicomplexa phylum

Babesia microti is a parasitic blood-borne piroplasm transmitted by deer ticks. B. microti is responsible for the disease babesiosis, a malaria-like disease which also causes fever and hemolysis.

<i>Rhipicephalus sanguineus</i> Species of species of tick found worldwide

Rhipicephalus sanguineus, commonly called the brown dog tick, kennel tick, or pantropical dog tick, is a species of tick found worldwide, but more commonly in warmer climates. This species is unusual among ticks in that its entire lifecycle can be completed indoors. The brown dog tick is easily recognized by its reddish-brown color, elongated body shape, and hexagonal basis capituli. Adults are 2.28 to 3.18 mm in length and 1.11 to 1.68 mm in width. They do not have ornamentation on their backs.

Ehrlichia canis is an obligate intracellular bacterium that acts as the causative agent of ehrlichiosis, a disease most commonly affecting canine species. This pathogen is present throughout the United States, South America, Asia, Africa and recently in the Kimberley region of Australia. First defined in 1935, E. canis emerged in the United States in 1963 and its presence has since been found in all 48 contiguous United States. Reported primarily in dogs, E. canis has also been documented in felines and humans, where it is transferred most commonly via Rhipicephalus sanguineus, the brown dog tick.

<span class="mw-page-title-main">Apicomplexan life cycle</span> Apicomplexa life cycle

Apicomplexans, a group of intracellular parasites, have life cycle stages that allow them to survive the wide variety of environments they are exposed to during their complex life cycle. Each stage in the life cycle of an apicomplexan organism is typified by a cellular variety with a distinct morphology and biochemistry.

<i>Babesia bovis</i> Species of single-celled organism

Babesia bovis is an Apicomplexan single-celled parasite of cattle which occasionally infects humans. The disease it and other members of the genus Babesia cause is a hemolytic anemia known as babesiosis and colloquially called Texas cattle fever, redwater or piroplasmosis. It is transmitted by bites from infected larval ticks of the order Ixodida. It was eradicated from the United States by 1943, but is still present in Mexico and much of the world's tropics. The chief vector of Babesia species is the southern cattle fever tick Rhipicephalus microplus.

<i>Theileria parva</i> Species of single-celled organism

Theileria parva is a species of parasites, named in honour of Arnold Theiler, that causes East Coast fever (theileriosis) in cattle, a costly disease in Africa. The main vector for T. parva is the tick Rhipicephalus appendiculatus. Theiler found that East Coast fever was not the same as redwater, but caused by a different protozoan.

<span class="mw-page-title-main">Ticks of domestic animals</span>

Ticks of domestic animals directly cause poor health and loss of production to their hosts. Ticks also transmit numerous kinds of viruses, bacteria, and protozoa between domestic animals. These microbes cause diseases which can be severely debilitating or fatal to domestic animals, and may also affect humans. Ticks are especially important to domestic animals in tropical and subtropical countries, where the warm climate enables many species to flourish. Also, the large populations of wild animals in warm countries provide a reservoir of ticks and infective microbes that spread to domestic animals. Farmers of livestock animals use many methods to control ticks, and related treatments are used to reduce infestation of companion animals.

Cytauxzoon is a genus of parasitic alveolates in the phylum Apicomplexa. The name is derived from the Greek meaning an increase in the number of cells in an animal.

<i>Plasmodium cynomolgi</i> Species of single-celled organism

Plasmodium cynomolgi is an apicomplexan parasite that infects mosquitoes and Asian Old World monkeys. In recent years, a number of natural infections of humans have also been documented. This species has been used as a model for human Plasmodium vivax because Plasmodium cynomolgi shares the same life cycle and some important biological features with P. vivax.

References

  1. Cornell University. "Babesia Canis". Cornell.
  2. 1 2 Irwin, Peter. "Canine Babesiosis" (PDF). Canine Babesiosis: 1141. Archived from the original (PDF) on 2013-12-11. Retrieved 2013-12-06.
  3. Halos, L.; Lebert, I.; Abrial, D.; Danlois, F.; Garzik, K.; Rodes, D.; Schillmeier, M.; Ducrot, C.; Guillot, J. (2014). "Questionnaire-based survey on the distribution and incidence of canine babesiosis in countries of Western Europe". Parasite. 21: 13. doi:10.1051/parasite/2014015. PMC   3952654 . PMID   24626325.
  4. Irwin, Peter. "Canine Babesiosis" (PDF). Canine Babesiosis: 1144. Archived from the original (PDF) on 2013-12-11. Retrieved 2013-12-06.
  5. 1 2 3 Marvista Vet. "Babesia Infection in Dogs". Archived from the original on 2014-02-16. Retrieved 2013-12-06.
  6. 1 2 3 4 5 "Babesia". Companion Animal Parasite Council. Archived from the original on 2013-12-12. Retrieved 2013-12-06.
  7. Mierzejewska, Ewa J.; Welc-Falęciak, Renata; Bednarska, Małgorzata; Rodo, Anna; Bajer, Anna (2014). "The first evidence for vertical transmission of Babesia canis in a litter of Central Asian Shepherd dogs". Annals of Agricultural and Environmental Medicine. 21 (3): 500–503. doi: 10.5604/12321966.1120590 . ISSN   1898-2263. PMID   25292117.
  8. Irwin, Peter. "Canine Babesiosis" (PDF). Canine Babesiosis: 1146. Archived from the original (PDF) on 2013-12-11. Retrieved 2013-12-06.