Chromosome 3 open reading frame 67 or C3orf67 is a protein that in humans is encoded by the gene C3orf67.[5][6] The function of C3orf67 is not yet fully understood.
The beginning of C3orf67 is predicted to consist of a series of beta strands and a couple alpha helices that coincide with the DUF667 domain. There are also alpha helices predicted in regions that correspond to the CM_mono2 and OCRE domains.[19][20][21]
Tertiary structure
Predicted tertiary structure of DUF667 region of C3orf67.
The DUF667 region is predicted to form a tube-like structure from a series of beta sheets.[21]
Orthologs have been identified for C3orf67 in species ranging from fungus, plants, hemichordates, parasites, fish, reptiles, birds, invertebrates, and mammals.
The promoter is well conserved across humans, gibbons, baboons, orangutans, cats, squirrels, alpacas, rabbits and mice.[22] There are several high quality transcription factor binding sites.[23] There are also several stem-loop structures that are predicted to be formed in the promoter region, some of which overlap with transcription factor binding sites.[24]
General tissue expression pattern of C3orf67.
Expression
C3orf67 is prominently expressed in the liver, tonsils, trachea, ovaries, testis, placenta, and colon. In other tissues it is expressed at low levels.[25] An increase in expression has been linked to small cell lung cancer.[26]
Function
The protein has been identified as one of seventeen (17) genes that may play a novel role in the intersection of tumor promotion and DNA-damaging stress and may be linked to carcinogenesis.[27]
Interacting Proteins
Transcription factors
There are three notable transcription factors that are known to be involved in the regulation of cell growth or immune responses:
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