C3orf67

Last updated
CFAP20DC
Identifiers
Aliases CFAP20DC , chromosome 3 open reading frame 67, C3orf67, CFAP20 domain containing
External IDs MGI: 1926154 HomoloGene: 18873 GeneCards: CFAP20DC
Orthologs
SpeciesHumanMouse
Entrez

200844

74430

Ensembl

ENSG00000163689

ENSMUSG00000021747

UniProt

Q6ZVT6

Q6P2K3

RefSeq (mRNA)

NM_028934

RefSeq (protein)

NP_083210

Location (UCSC) Chr 3: 58.72 – 59.05 Mb Chr 14: 13.8 – 14.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chromosome 3 open reading frame 67 or C3orf67 is a protein that in humans is encoded by the gene C3orf67. [5] [6] The function of C3orf67 is not yet fully understood.

Contents

Gene

C3orf67 is located at 3p14.2 on the reverse strand ranging from 58716417 to 59050045 base pairs. [7] [5] The accession number is NP_001338459.1. [8]

Protein

Map of C3orf67 with exon/exon boundaries, conserved domains, and highly conserved regions. Protein map.png
Map of C3orf67 with exon/exon boundaries, conserved domains, and highly conserved regions.

Primary sequence and isoforms

The coding sequence is 402-2681 base pairs of 3135 base pairs, [7] making up 759 amino acids. [5] [8] C3orf67 has six validated isoforms. [5] Isoform one is the most complete with 16 exons. [7] C3orf67 weighs 84.35 kilodaltons. [9]

Domains and motifs

There are three functional domains identified for C3orf67 [10]

Post-translational modifications

Map of conserved PTMs for C3orf67. Conserved PTM map.tif
Map of conserved PTMs for C3orf67.

Several post-translational modifications have been predicted for C3orf67 in conserved regions using various bioinformatic prediction tools [11] [12] [13] [14] [15] [16] [17] [18]

Secondary structure

The beginning of C3orf67 is predicted to consist of a series of beta strands and a couple alpha helices that coincide with the DUF667 domain. There are also alpha helices predicted in regions that correspond to the CM_mono2 and OCRE domains. [19] [20] [21]

Tertiary structure

Predicted tertiary structure of DUF667 region of C3orf67. C3orf67 - DUF667.png
Predicted tertiary structure of DUF667 region of C3orf67.

The DUF667 region is predicted to form a tube-like structure from a series of beta sheets. [21]

Homology and Evolution

Paralogs

There are no known paralogs of C3orf67.

Orthologs

Orthologs have been identified for C3orf67 in species ranging from fungus, plants, hemichordates, parasites, fish, reptiles, birds, invertebrates, and mammals.

Variety of orthologous species of C3orf67.
SpeciesCommon NameDate of Divergence (MYA)Accession NumberSequence Length (aa)% Identity
Orbicella faveolata Mountainous star coral824XP_020630732.1 / XP_020630739.184932.20%
Exaiptasia pallida Pale anemone824XP_020899564.179732.00%
Acanthaster planci Crown-of-thorns starfish684XP_022107809.197631.60%
Stylophora pistillata Smooth cauliflower coral824XP_022782397.182530.80%
Crassostrea gigas Pacific oyster797XP_011453705.195029.50%
Lingula anatina Lamp shell797XP_013404893.1107729.30%
Octopus bimaculoides California two-spotted octopus797XP_014778712.190229.10%
Saccoglossus kowalevskii Acorn worm684XP_006821003.159623.30%
Amphimedon queenslandica Sponge951.8XP_011402616.150822.70%
Mutation rate of C3orf67. Mutation rate of C3orf67.png
Mutation rate of C3orf67.

Distant homologs

Most distant homologs of C3orf67.
SpeciesCommon NameDate of Divergence (MYA)Accession NumberSequence Length (aa)% Identity
Trichinella spiralis Trichina worm797XP_003374081.139312.60%
Spizellomyces punctatus Unknown1105XP_016608387.11838.20%
Selaginella moellendorffii Spikemoss1496XP_002989784.12096.00%

Expression

Promoter

The promoter is well conserved across humans, gibbons, baboons, orangutans, cats, squirrels, alpacas, rabbits and mice. [22] There are several high quality transcription factor binding sites. [23] There are also several stem-loop structures that are predicted to be formed in the promoter region, some of which overlap with transcription factor binding sites. [24]

General tissue expression pattern of C3orf67. Tissue expression C3orf67.png
General tissue expression pattern of C3orf67.

Expression

C3orf67 is prominently expressed in the liver, tonsils, trachea, ovaries, testis, placenta, and colon. In other tissues it is expressed at low levels. [25] An increase in expression has been linked to small cell lung cancer. [26]

Function

The protein has been identified as one of seventeen (17) genes that may play a novel role in the intersection of tumor promotion and DNA-damaging stress and may be linked to carcinogenesis. [27]

Interacting Proteins

Transcription factors

There are three notable transcription factors that are known to be involved in the regulation of cell growth or immune responses:

Other interacting proteins

Several other proteins have been predicted to interact with C3orf67:

Related Research Articles

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