CRYGS | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CRYGS , CRYG8, CTRCT20, crystallin gamma S | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 123730 MGI: 1298216 HomoloGene: 40695 GeneCards: CRYGS | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Gamma-crystallin S is a protein that in humans is encoded by the CRYGS gene. [5]
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins.
Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue.
Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [5]
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is an enzyme that in humans is encoded by the AGA gene.
Acyl-CoA-binding protein in humans belongs to the family of Acyl-CoA-binding proteins.
5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.
Gamma-crystallin D is a protein that in humans is encoded by the CRYGD gene.
Beta-crystallin B2 is a protein that in humans is encoded by the CRYBB2 gene.
Crystallin, gamma C, also known as CRYGC, is a protein which in humans is encoded by the CRYGC gene.
Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.
Beta-crystallin B1 is a protein that in humans is encoded by the CRYBB1 gene. Variants in CRYBB1 are associated with autosomal dominant congenital cataract.
Gamma-crystallin B is a protein that in humans is encoded by the CRYGB gene.
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
Beta-crystallin A3 is a protein that in humans is encoded by the CRYBA1 gene.
5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.
CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.
Beta-crystallin A4 is a protein that in humans is encoded by the CRYBA4 gene.
Quinone oxidoreductase is an enzyme that in humans is encoded by the CRYZ gene.
Beta-crystallin B3 is a protein that in humans is encoded by the CRYBB3 gene.
Gamma-crystallin A is a protein that in humans is encoded by the CRYGA gene.
Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene.
Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene.
Dystrobrevin beta is a protein which in humans is encoded by the DTNB gene.