Carbonic anhydrase 5B, mitochondrial

Last updated
CA5B
Identifiers
Aliases CA5B , CA-VB, carbonic anhydrase 5B, CAVB
External IDs OMIM: 300230 MGI: 1926249 HomoloGene: 21413 GeneCards: CA5B
Orthologs
SpeciesHumanMouse
Entrez

11238

56078

Ensembl

ENSG00000169239

ENSMUSG00000031373

UniProt

Q9Y2D0

Q9QZA0

RefSeq (mRNA)

NM_007220

NM_181315

RefSeq (protein)

NP_009151
NP_009151.1

NP_851832

Location (UCSC) Chr X: 15.69 – 15.79 Mb Chr X: 162.76 – 162.81 Mb
PubMed search [3] [4]
Wikidata
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Carbonic anhydrase 5B, mitochondrial is an enzyme that in humans is encoded by the CA5B gene. [5] [6]

Contents

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. [6]

Related Research Articles

Carbonic anhydrase II Protein-coding gene in the species Homo sapiens

Carbonic anhydrase II, is one of sixteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of bicarbonate ions in the proximal tubule. Loss of carbonic anhydrase activity in bones impairs the ability of osteoclasts to promote bone resorption, leading to osteopetrosis.

Carbonic anhydrase III, muscle specific Protein-coding gene in the species Homo sapiens

Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.

MRGPRF Protein-coding gene in the species Homo sapiens

MAS-related GPR, member F, also known as MRGPRF, is a human gene.

CA1 (gene) Protein-coding gene in the species Homo sapiens

Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene.

Carbonic anhydrase 4

Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene.

Carbonic anhydrase 12

Carbonic anhydrase 12 is an enzyme that in humans is encoded by the CA12 gene.

Carbonic anhydrase VI Protein-coding gene in the species Homo sapiens

Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene. It is also called 'gustin' because of its presence in saliva, and lower-than-normal levels of salivary zinc in individuals with hypogeusia.

CA10

Carbonic anhydrase-related protein 10 is an enzyme that in humans is encoded by the CA10 gene.

ABCB6 Protein-coding gene in the species Homo sapiens

ATP-binding cassette super-family B member 6, mitochondrial is a protein that in humans is encoded by the ABCB6 gene.

LYPLA1 Protein-coding gene in the species Homo sapiens

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.

COX7A2

Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene.

CA8 Protein-coding gene in the species Homo sapiens

Carbonic anhydrase-related protein is a protein that in humans is encoded by the CA8 gene. The CA8 protein lacks the catalytic activity of other carbonic anhydrase enzymes. A rare, autosomal recessive form of cerebellar ataxia known as "cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3" (CAMRQ3) is caused by mutations in the CA8 gene.

CACNG3

Voltage-dependent calcium channel gamma-3 subunit is a protein that in humans is encoded by the CACNG3 gene.

Carbonic anhydrase 14 Protein-coding gene in the species Homo sapiens

Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene.

NDUFC2

NADH dehydrogenase [ubiquinone] 1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene.

NDUFS5 Protein-coding gene in the species Homo sapiens

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 is an enzyme that in humans is encoded by the NDUFS5 gene.

Carbonic anhydrase 7

Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.

CA11 Protein-coding gene in the species Homo sapiens

Carbonic anhydrase-related protein 11 is a protein that in humans is encoded by the CA11 gene.

TSFM

Elongation factor Ts, mitochondrial is a protein that in humans is encoded by the TSFM gene. It is an EF-Ts homolog.

Carbonic anhydrase 5A, mitochondrial

Carbonic anhydrase 5A, mitochondrial is a protein that in humans is encoded by the CA5A gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169239 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031373 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (Aug 1999). "Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x". J Biol Chem. 274 (30): 21228–33. doi: 10.1074/jbc.274.30.21228 . PMID   10409679.
  6. 1 2 "Entrez Gene: CA5B carbonic anhydrase VB, mitochondrial".

Further reading


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