FUCA2

FUCA2
Identifiers
Aliases	FUCA2 , dJ20N2.5, fucosidase, alpha-L- 2, plasma, alpha-L-fucosidase 2
External IDs	OMIM: 136820 MGI: 1914098 HomoloGene: 119 GeneCards: FUCA2
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q24.2 Start 143,494,812 bp [1] End 143,511,720 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A2 Start 13,375,284 bp [2] End 13,394,779 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans stromal cell of endometrium rectum monocyte left adrenal gland right adrenal gland duodenum body of pancreas metanephros gallbladder Top expressed in interventricular septum proximal tubule kidney ileum seminal vesicula myocardium of ventricle cardiac muscles duodenum epithelium of stomach submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity alpha-L-fucosidase activity hydrolase activity, acting on glycosyl bonds protein binding Cellular component extracellular exosome extracellular region extracellular space azurophil granule lumen endoplasmic reticulum lumen lysosome Biological process fucose metabolic process metabolism glycoside catabolic process neutrophil degranulation post-translational protein modification carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2519 66848 Ensembl ENSG00000001036 ENSMUSG00000019810 UniProt Q9BTY2 Q7Z6V2 Q99KR8 RefSeq (mRNA) NM_032020 NM_025799 NM_001330198 RefSeq (protein) NP_114409 NP_001317127 NP_080075 Location (UCSC) Chr 6: 143.49 – 143.51 Mb Chr 10: 13.38 – 13.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Plasma alpha-L-fucosidase (see alpha-L-fucosidase) is an enzyme that in humans is encoded by the FUCA2 gene. ^{[5] [6]}

See also

• Tissue alpha-L-fucosidase, encoded by FUCA1 gene

References

1. GRCh38: Ensembl release 89: ENSG00000001036 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019810 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eiberg H, Mohr J, Nielsen LS (Oct 1984). "Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system". Clin Genet. 26 (1): 23–9. doi:10.1111/j.1399-0004.1984.tb00782.x. PMID   6590153. S2CID   85371006.
6. "Entrez Gene: FUCA2 fucosidase, alpha-L- 2, plasma".

Further reading

• Narahara K, Tsuji K, Yokoyama Y, et al. (1991). "Specification of small distal 6q deletions in two patients by gene dosage and in situ hybridization study of plasminogen and alpha-L-fucosidase 2". Am. J. Med. Genet. 40 (3): 348–53. doi:10.1002/ajmg.1320400322. PMID   1951444.
• O'Brien JS, Willems PJ, Fukushima H, et al. (1988). "Molecular biology of the alpha-L-fucosidase gene and fucosidosis". Enzyme. 38 (1–4): 45–53. doi:10.1159/000469189. PMID   2894306.
• Cordero OJ, Merino A, Páez de la Cadena M, et al. (2001). "Cell surface human alpha-L-fucosidase". Eur. J. Biochem. 268 (11): 3321–31. doi: 10.1046/j.1432-1327.2001.02237.x . PMID   11389735.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.