GPM6A

GPM6A
Identifiers
Aliases	GPM6A , GPM6, M6A, glycoprotein M6A
External IDs	OMIM: 601275; MGI: 107671; HomoloGene: 3864; GeneCards: GPM6A; OMA:GPM6A - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q34.2 Start 175,632,934 bp [1] End 176,002,664 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B1.3 Start 55,407,878 bp [2] End 55,513,906 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 entorhinal cortex superior frontal gyrus orbitofrontal cortex Region I of hippocampus proper postcentral gyrus primary visual cortex middle temporal gyrus paraflocculus of cerebellum Top expressed in subiculum piriform cortex anterior amygdaloid area Region I of hippocampus proper lobe of cerebellum primary motor cortex cingulate gyrus lateral septal nucleus cerebellar vermis prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium channel activity protein binding Cellular component integral component of membrane extracellular vesicle cell projection membrane filopodium plasma membrane dendritic spine axonal growth cone axon soma neuron projection extracellular exosome glutamatergic synapse integral component of presynaptic active zone membrane Biological process neuron projection morphogenesis neuron migration stem cell differentiation nervous system development calcium ion transmembrane transport synapse assembly positive regulation of filopodium assembly neural retina development response to bacterium neuron projection development regulation of synapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2823 234267 Ensembl ENSG00000150625 ENSMUSG00000031517 UniProt P51674 P35802 RefSeq (mRNA) NM_001261447 NM_001261448 NM_005277 NM_201591 NM_201592 NM_001388090 NM_001388091 NM_001253754 NM_001253756 NM_153581 RefSeq (protein) NP_001248376 NP_001248377 NP_005268 NP_963885 NP_963886 NP_001240683 NP_001240685 NP_705809 Location (UCSC) Chr 4: 175.63 – 176 Mb Chr 8: 55.41 – 55.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000150625 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031517 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, et al. (May 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID   8661015.
6. Liang YJ, Wu DF, Stumm R, Höllt V, Koch T (July 2008). "Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway". Cell Research. 18 (7): 768–79. doi: 10.1038/cr.2008.71 . PMID   18574501.
7. "Entrez Gene: GPM6A glycoprotein M6A".

Further reading

• Boks MP, Hoogendoorn M, Jungerius BJ, Bakker SC, Sommer IE, Sinke RJ, et al. (September 2008). "Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (6): 707–11. doi:10.1002/ajmg.b.30667. PMID   18163405. S2CID   30736289.
• DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research. 4 (2): 306–15. doi:10.1021/pr0498436. PMID   15822905.
• Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, et al. (February 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi: 10.1074/jbc.M210455200 . PMID   12493773.
• Mukobata S, Hibino T, Sugiyama A, Urano Y, Inatomi A, Kanai Y, et al. (October 2002). "M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation". Biochemical and Biophysical Research Communications. 297 (4): 722–8. doi:10.1016/S0006-291X(02)02284-2. PMID   12359212.
• Shimizu F, Watanabe TK, Fujiwara T, Takahashi E, Nakamura Y, Maekawa H (1996). "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33→q34". Cytogenetics and Cell Genetics. 74 (1–2): 138–9. doi:10.1159/000134401. PMID   8893821.
• Yan Y, Narayanan V, Lagenaur C (July 1996). "Expression of members of the proteolipid protein gene family in the developing murine central nervous system". The Journal of Comparative Neurology. 370 (4): 465–78. doi:10.1002/(SICI)1096-9861(19960708)370:4<465::AID-CNE4>3.0.CO;2-2. PMID   8807448. S2CID   27877672.