Gustav III of Sweden's coffee experiment was a purported twin study ordered by the king to study the health effects of coffee. The authenticity of the event has been questioned. [1] The primitive medical study, supposedly conducted in the second half of the 18th century, failed to prove that coffee was a dangerous beverage.
In Sweden coffee was banned by royal decree across three different reigns, in five separate periods between the 1750s and the 1820s: 1756–61, 1766–69, 1794–6, 1799–1802 and 1817–1823. [2]
Coffee first arrived in Sweden around 1674, [1] but was little used until the turn of the 18th century when it became fashionable among the wealthy. [3] [4] In 1746, a royal edict was issued against coffee and tea due to "the misuse and excesses of tea and coffee drinking". [3] Heavy taxes were levied on consumption, and failure to pay the tax on the substance resulted in fines and confiscation of cups and dishes. [3] Later, coffee was banned completely; despite the ban, consumption continued. [3]
Gustav's father, Adolph Frederick, had also been an opponent of stimulating drinks, signing the Misuse and Excesses Tea and Coffee Drinking Edict in 1760. [5] Both Gustav III and his father had read and been strongly influenced by a 1715 treatise from a French physician on the dangers of what would later be identified as caffeine in tea and coffee. [6]
Gustav III viewed coffee consumption as a threat to the public health and was determined to prove its negative health effects. To this end he ordered a scientific experiment to be carried out in what has been loosely referred to as the first randomized controlled clinical trial. [4]
The king ordered the experiment to be conducted using a pair of identical twins. Both of the twins had been tried for the crimes they had committed and condemned to death. Their sentences were commuted to life imprisonment on the condition that one of the twins drink three pots [1] of coffee, and the other drink the same amount of tea, every day for the rest of their lives. [7]
The tea drinking twin died first at the age of 83, long after the death of Gustav III, who was assassinated in 1792. The age of the coffee-drinking twin at his death is unknown, as both doctors assigned by the king to monitor this study predeceased him. [7] [5] [8] [9]
In 1794, the government once again tried to impose a ban on coffee. The ban, which was renewed in 1799 and 1817, was never successful in stamping out coffee-drinking. [3] Once the ban was lifted in 1823, coffee became a dominant beverage in Sweden, which since has been one of the countries with the highest coffee consumption per capita in the world. [7] [2]
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. It is mainly used as a eugeroic (wakefulness promoter) or as a mild cognitive enhancer to increase alertness and attentional performance. Caffeine acts by blocking binding of adenosine to the adenosine A1 receptor, which enhances release of the neurotransmitter acetylcholine. Caffeine has a three-dimensional structure similar to that of adenosine, which allows it to bind and block its receptors. Caffeine also increases cyclic AMP levels through nonselective inhibition of phosphodiesterase.
A drink or beverage is a liquid intended for human consumption. In addition to their basic function of satisfying thirst, drinks play important roles in human culture. Common types of drinks include plain drinking water, milk, juice, smoothies and soft drinks. Traditionally warm beverages include coffee, tea, and hot chocolate. Caffeinated drinks that contain the stimulant caffeine have a long history.
Tea is an aromatic beverage prepared by pouring hot or boiling water over cured or fresh leaves of Camellia sinensis, an evergreen shrub native to East Asia which probably originated in the borderlands of southwestern China and northern Myanmar. Tea is also made, but rarely, from the leaves of Camellia taliensis. After plain water, tea is the most widely consumed drink in the world. There are many different types of tea; some have a cooling, slightly bitter, and astringent flavour, while others have profiles that include sweet, nutty, floral, or grassy notes. Tea has a stimulating effect in humans, primarily due to its caffeine content.
Yerba mate or yerba-maté is a plant species of the holly genus Ilex native to South America. It was named by the French botanist Augustin Saint-Hilaire. The leaves of the plant can be steeped in hot water to make a beverage known as mate. Brewed cold, it is used to make tereré. Both the plant and the beverage contain caffeine.
Caffeinism is a state of intoxication caused by excessive consumption of caffeine. This intoxication covers a variety of unpleasant physical and mental symptoms associated with the consumption of excessive amounts of caffeine.
The "Word of Wisdom" is the common name of an 1833 section of the Doctrine and Covenants, a book considered by many churches within the Latter Day Saint movement to be a sacred text. The section defines beliefs regarding certain drugs, nutritious ingredients in general, and the counsel to eat meat sparingly; it also offers promises to those who follow the guidance of the Word of Wisdom.
An energy drink is a type of functional beverage containing stimulant compounds, usually caffeine, which is marketed as providing mental and physical stimulation. They may or may not be carbonated and may also contain sugar, other sweeteners, or herbal extracts, among numerous other possible ingredients.
Coffee is a beverage brewed from roasted coffee beans. Darkly colored, bitter, and slightly acidic, coffee has a stimulating effect on humans, primarily due to its caffeine content. It has the highest sales in the world market for hot drinks.
A caffeinated drink, or caffeinated beverage, is a drink that contains caffeine, a stimulant that is legal practically all over the world. Some are naturally caffeinated while others have caffeine added as an ingredient.
Vodka Red Bull is a caffeinated alcoholic drink consisting of the energy drink Red Bull and varying amounts of vodka. Although some people consider it a cocktail, it fails to meet this definition under the International Bartending Association's criteria.
Although health benefits have been assumed throughout the history of using Camellia sinensis as a common beverage, there is no high-quality evidence that consuming tea confers significant benefits other than possibly increasing alertness, an effect caused by caffeine in the tea leaves. In clinical research conducted over the early 21st century, tea has been studied extensively for its potential to lower the risk of human diseases, but there is no good scientific evidence to indicate that consuming tea affects any disease or improves health.
Yaupon tea is refers to several kinds of caffeinated beverages originally brewed by Native Americans in the Southeastern United States and later adopted by Europeans and Americans. It is generally brewed from yaupon holly, which is native to the Atlantic and Gulf Coasts, and is related to Yerba mate and Guayusa. The Native drink may also have included the related dahoon holly and other herbs.
Caffeine dependence is a condition characterized by a set of criteria, including tolerance, withdrawal symptoms, persistent desire or unsuccessful efforts to control use, and continued use despite knowledge of adverse consequences attributed to caffeine. It can appear in physical dependence or psychological dependence, or both. Caffeine is one of the most common additives in many consumer products, including pills and beverages such as caffeinated alcoholic beverages, energy drinks, pain reliever medications, and colas. Caffeine is found naturally in various plants such as coffee and tea. Studies have found that 89 percent of adults in the U.S. consume on average 200 mg of caffeine daily. One area of concern that has been presented is the relationship between pregnancy and caffeine consumption. Repeated caffeine doses of 100mg appeared to result in smaller size at birth in newborns. When looking at birth weight however, caffeine consumption did not appear to make an impact.
The health effects of coffee include various possible health benefits and health risks.
Coffee substitutes are non-coffee products, usually without caffeine, that are used to imitate coffee. Coffee substitutes can be used for medical, economic and religious reasons, or simply because coffee is not readily available. Roasted grain beverages are common substitutes for coffee.
Caffeine-induced sleep disorder is a psychiatric disorder that results from overconsumption of the stimulant caffeine. Caffeine is one of the most widely consumed psychoactive drugs: almost 90% of Americans in a survey consume some type of caffeine each day. "When caffeine is consumed immediately before bedtime or .... throughout the day, sleep onset may be delayed, total sleep time reduced, normal stages of sleep altered, and the quality of sleep decreased." Caffeine reduces slow-wave sleep in the early part of the sleep cycle and can reduce rapid eye movement sleep later in the cycle. Caffeine increases episodes of wakefulness, and high doses in the late evening can increase sleep onset latency. In elderly people, there is an association between use of medication containing caffeine and difficulty in falling asleep.
Coffee cherry tea is an herbal tea made from the dried skins and/or pulp of the fruit of the coffee plant that remain after the coffee beans have been collected from within. It is also known as cascara, from the Spanish cáscara, meaning "husk". It is similar to a traditional beverage in Yemen and Ethiopia. Starting about 2005 it was independently developed and promoted for export by Salvadoran coffee farmer Aida Batlle. The dried whole fruits are also eaten like raisins.
A caffeinated alcoholic drink is a drink that contains both alcohol and a significant amount of caffeine. Caffeine, a stimulant, masks some of the depressant effects of alcohol. However, in 2010 and 2011, this type of drink faced criticism for posing health risks to its drinkers. In some places there is a ban on caffeinated alcoholic drinks.
The 17 November 2010 United States ban on caffeinated alcoholic drinks is a ban which prevents the marketing and distribution of any prepackaged caffeinated alcoholic drink.
Free refills occur when a drink's receptacle, usually that of a soft drink, tea or coffee, is allowed to be filled again by its purchaser, free of charge, after they have consumed the drink. Occasionally the glass or cup holding the drink is not reused, and the "refill" actually constitutes the acquisition of a second additional entirely new drink(s) for no added charge, usually of the same kind as the original, paid-for drink. Free refills are commonplace in the United States and Canada in traditional restaurants and fast food restaurants, while rarer in airports, cafés, or service stations. Around the world, the availability of free refills is typically scarce, but varies widely depending on the country and the type and specific ownership or chain of each establishment.
