Leprosy, also known as Hansen's disease (HD), is a long-term infection by the bacteria Mycobacterium leprae or Mycobacterium lepromatosis. Infection can lead to damage of the nerves, respiratory tract, skin, and eyes. This nerve damage may result in a lack of ability to feel pain, which can lead to the loss of parts of a person's extremities from repeated injuries or infection through unnoticed wounds. An infected person may also experience muscle weakness and poor eyesight. Leprosy symptoms may begin within one year, but, for some people, symptoms may take 20 years or more to occur.
A leper colony, also known by many other names, is an isolated community for the quarantining and treatment of lepers, people suffering from leprosy. M. leprae, the bacterium responsible for leprosy, is believed to have spread from East Africa through the Middle East, Europe, and Asia by the 5th century before reaching the rest of the world more recently. Historically, leprosy was believed to be extremely contagious and divinely ordained, leading to enormous stigma against its sufferers. Other severe skin diseases were frequently conflated with leprosy and all such sufferers were kept away from the general public, although some religious orders provided medical care and treatment. Recent research has shown M. leprae has maintained a similarly virulent genome over at least the last thousand years, leaving it unclear which precise factors led to leprosy's near elimination in Europe by 1700. A growing number of cases following the first wave of European colonization, however, led to increased attention towards leprosy during the New Imperialism of the late 19th century. Following G.A. Hansen's discovery of the role of M. leprae in the disease, the First International Leprosy Conference held in Berlin in 1897 renewed interest and investment in the isolation of lepers throughout the European colonial empires. Although Western countries now generally treat cases of leprosy individually on an outpatient basis, traditional isolated colonies continue to exist in India, China, and some other countries.
Lepra is a UK-based international charity established in 1924, working to diagnose, treat, and rehabilitate people with leprosy. Lepra currently works in India, Bangladesh and Zimbabwe.
Achariaceae is a family of flowering plants consisting of 32-33 genera with about 155 species of tropical herbs, shrubs, and trees. The APG IV system has greatly expanded the scope of the family by including many genera previously classified in Flacourtiaceae. Molecular data strongly support the inclusion of this family in the order Malpighiales.
Sir Leonard Rogers was a founder member of the Royal Society of Tropical Medicine and Hygiene, and its President from 1933 to 1935.
Hydnocarpus is a genus of medium to large trees in the Family Achariaceae; the genus was previously placed in the now defunct family Flacourtiaceae. Species have been recorded from Indochina, Indonesia, Malaysia and the Philippines.
Jasminum grandiflorum, also known variously as the Spanish jasmine, Royal jasmine, Catalan jasmine, Sicilian jasmine, is a species of jasmine native to South Asia, the Arabian peninsula, East and Northeast Africa and the Yunnan and Sichuan regions of China. The species is widely cultivated and is reportedly naturalized in Guinea, the Maldive Islands, Mauritius, Réunion, Java, the Cook Islands, Chiapas, Central America, and the Caribbean.It is closely related to, and sometimes treated as merely a form of, Jasminum officinale. The plant is known as "saman pichcha" or "pichcha" in Sri Lanka.
Hydnocarpus kurzii is a species of plant in the family Achariaceae. It is found in India and Myanmar.
Crocodile oil is extracted from the fatty tissues of crocodiles. Crocodile fat is a product of commercial farming, evident in Thailand. Historically, for centuries crocodile oil has been used by traditional practitioners across the globe, including Chinese Traditional Medicine, Southeast Asia, Ancient Egypt. Crocodile oil was found to be used since the 19th century for different purposes in different cultures. Due to the oil's components, its richness in monounsaturated and Polyunsaturated fats, it is today commonly used as ointment for treatment of skin conditions, skin structure enhancement, collagen deposition, and medicine for illnesses. In recent times, the use of crocodile oil has invited criticism from the use of crocodile oil as there is an increased demand for cruelty-free and vegan-friendly beauty products in consumers of today's society.
Kensuke Mitsuda was a Japanese leprologist and director of the Tama Zenshoen Sanatorium (1914–1931) and the National Sanatorium Nagashima Aiseien (1931–1957). He had been at the frontier of leprosy policy of Japan. He was given the Order of Cultural Merits (1951) and Damien-Dutton Award (1961). He has been the cause of admiration from one side, and the target of criticism from the other.
Heibei Okamura (1852–1934) produced Japan's finest "Okamura's" chaulmoogra oil,, between about 1892 and 1944 at Sakai, Osaka, Japan. Chaulmoogra oil, which is taken from capsular fruits of Hydnocarpus genus trees of Thailand, Indonesia, Malaysia and the Philippines, had been the only one remedy in wide use before Guy Henry Faget proved the efficacy of promin in 1943 Promin started the era of sulfon chemicals and revolutionalized the treatment of leprosy. Okamura was also known for caring for more than 1,000 leprosy patients between 1888 and 1901 in his house.
Hydnocarpus wightianus or chaulmoogra is a tree in the Achariaceae family. Hydnocarpus wightiana seed oil has been widely used in traditional Indian medicine, especially in Ayurveda, and in Chinese traditional medicine for the treatment of leprosy. It entered early Western medicine in the nineteenth century before the era of sulfonamides and other antibiotics for the treatment of several skin diseases and leprosy. The oil was prescribed for leprosy as a mixture suspended in gum or as an emulsion.
Dipterocarpus turbinatus is a species of tree in the family Dipterocarpaceae native to north-eastern India and mainland Southeast Asia, and cultivated in surrounding regions. It is an important source of the wood known as keruing, and is often used in the plywood industry.
The history of leprosy was traced to its origins by an international team of 22 geneticists using comparative genomics of the worldwide distribution of Mycobacterium leprae. Monot et al. (2005) determined that leprosy originated in East Africa or the Near East and traveled with humans along their migration routes, including those of trade in goods and slaves. The four strains of M. leprae are based in specific geographic regions where each predominantly occurs:
Alice Augusta Ball was an American chemist who developed the "Ball Method", the most effective treatment for leprosy during the early 20th century. She was the first woman and first African American to receive a master's degree from the University of Hawaii, and was also the university's first female and African American chemistry professor. She died at age 24 and her contributions to science were not recognized until many years after her death.
Isaac Santra was an Indian physician, gandhian and social worker, known for his contributions for the eradication of Leprosy from India. The Government of India honoured him in 1956, with the award of Padma Shri, the fourth highest Indian civilian award for his services to the nation.
Isabella Kerr was a Scottish medical missionary who worked in India in the early 20th-century. She created the Victoria Leprosy Centre in Hyderabad. She worked to cure leprosy in India.
The medical ethnobotany of India is the study of Indian medicinal plants and their traditional uses. Plants have been used in India for treatment of disease and health maintenance for thousands of years, and remain important staples of health and folk medicine for millions. Indians today utilize plants for both primary medical care and as supplementary treatment alongside modern medical science. It is estimated that 70% of rural Indians use traditional plant based remedies for primary healthcare needs. This reliance of plants for medicine is consistent with trends widely observed in the developing world, where between 65% and 80% of people use medicinal plant remedies.
Ernest Muir FRCS, CIE, CMG was a Scottish medical missionary and educator in British-controlled India and Nigeria most noted for his work with Hansen's disease (leprosy).
