Hopea hainanensis

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Hopea hainanensis
Hopea hainanensis at Taman Rekreasi Taman Sutera, Kajang 20230708 170131.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Malvales
Family: Dipterocarpaceae
Genus: Hopea
Species:
H. hainanensis
Binomial name
Hopea hainanensis
Merr. & Chun

Hopea hainanensis is a species of tree in the family Dipterocarpaceae. It is found in Hainan Island of China and northern Vietnam. Hopea hainanensis produces the acetylcholinesterase inhibitor Hopeahainol A. [2]

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Huprine X is a synthetic cholinergic compound developed as a hybrid between the natural product Huperzine A and the synthetic drug tacrine. It is one of the most potent reversible inhibitors of acetylcholinesterase known, with a binding affinity of 0.026nM, as well as showing direct agonist activity at both nicotinic and muscarinic acetylcholine receptors. In animal studies it has nootropic and neuroprotective effects, and is used in research into Alzheimer's disease, and although huprine X itself has not been researched for medical use in humans, a large family of related derivatives have been developed.

<span class="mw-page-title-main">Hopeahainol A</span> Chemical compound

Hopeahainol A is a polyphenol acetylcholinesterase inhibitor with the molecular formula C56H42O12. Hopeahainol A has been isolated from the tree Hopea hainanensis. Hopeahainol A may be used for the treatment of Alzheimer's disease.

References

  1. Ly, V.; Nanthavong, K.; Pooma, R.; Hoang, V.S.; Khou, E.; Newman, M.F. (2018). "Hopea hainanensis". IUCN Red List of Threatened Species . 2018: e.T32357A2816074. doi: 10.2305/IUCN.UK.2018-1.RLTS.T32357A2816074.en . Retrieved 17 November 2021.
  2. Ge, Hui Ming; Zhu, Chun Hua; Shi, Da Hua; Zhang, Li Dong; Xie, Dai Qian; Yang, Jie; Ng, Seik Weng; Tan, Ren Xiang (January 2008). "Hopeahainol A: An Acetylcholinesterase Inhibitor from Hopea hainanensis". Chemistry - A European Journal. 14 (1): 376–381. doi:10.1002/chem.200700960.