Malonyl CoA reductase (malonate semialdehyde-forming)

Malonyl CoA reductase (malonate semialdehyde-forming)
Identifiers
EC no.	1.2.1.75
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Malonyl CoA reductase (malonate semialdehyde-forming) (EC 1.2.1.75, NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with systematic name malonate semialdehyde:NADP⁺ oxidoreductase (malonate semialdehyde-forming). ^{[1] [2] [3] [4]} This enzyme catalyse the following chemical reaction

malonate semialdehyde + CoA + NADP⁺${\displaystyle \rightleftharpoons }$ malonyl-CoA + NADPH + H⁺

Requires Mg²⁺. Catalyses the reduction of malonyl-CoA to malonate semialdehyde.

References

1. Strauss G, Fuchs G (August 1993). "Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle". European Journal of Biochemistry. 215 (3): 633–43. doi: 10.1111/j.1432-1033.1993.tb18074.x . PMID   8354269.
2. Berg IA, Kockelkorn D, Buckel W, Fuchs G (December 2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science. 318 (5857): 1782–6. Bibcode:2007Sci...318.1782B. doi:10.1126/science.1149976. PMID   18079405.
3. Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G (December 2006). "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp" (PDF). Journal of Bacteriology. 188 (24): 8551–9. doi:10.1128/JB.00987-06. PMC   1698253 . PMID   17041055.
4. Hügler M, Menendez C, Schägger H, Fuchs G (May 2002). "Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation". Journal of Bacteriology. 184 (9): 2404–10. doi:10.1128/jb.184.9.2404-2410.2002. PMC   134993 . PMID   11948153.

External links

• Malonyl+CoA+reductase+(malonate+semialdehyde-forming) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)