Methenyltetrahydrofolate cyclohydrolase

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methenyltetrahydrofolate cyclohydrolase
1dib.jpg
Methenyltetrahydrofolate cyclohydrolase dimer, Human
Identifiers
EC no. 3.5.4.9
CAS no. 9027-97-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) is an enzyme that catalyzes the chemical reaction

Contents

5,10-methenyltetrahydrofolate + H2O 10-formyltetrahydrofolate

Thus, the two substrates of this enzyme are 5,10-methenyltetrahydrofolate and H2O, whereas its product is 10-formyltetrahydrofolate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines.

This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

Synonyms

The systematic name of this enzyme class is 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing).

Other names in common use include:

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1A4I, 1DIA, 1DIB, 1DIG, 2C2X, and 2C2Y.

References