Methylenediurea deaminase

Methylenediurea deaminase
Identifiers
EC no.	3.5.3.21
CAS no.	205830-62-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Methylenediurea deaminase (EC 3.5.3.21, methylenediurease) is an enzyme with systematic name methylenediurea aminohydrolase found in Brucella anthropi , a bacterium. ^[1] This enzyme catalyses the following chemical reaction:

methylenediurea + 2 H₂O ${\displaystyle \rightleftharpoons }$ N-(hydroxymethyl)urea + 2 NH₃ + CO₂ (overall reaction)

(1a) methylenediurea + H₂O ${\displaystyle \rightleftharpoons }$ N-(carboxyaminomethyl)urea + NH₃

(1b) N-(carboxyaminomethyl)urea ${\displaystyle \rightleftharpoons }$ N-(aminomethyl)urea + CO₂ (spontaneous)

(1c) N-(aminomethyl)urea + H₂O ${\displaystyle \rightleftharpoons }$ N-(hydroxymethyl)urea + NH₃ (spontaneous)

Methylenediurea is hydrolysed and decarboxylated to give an aminated methylurea.

References

1. Jahns T, Schepp R, Kaltwasser H (1997). "Purification and characterisation of an enzyme from a strain of Ochrobactrum anthroπ that degrades condensation products of urea and formaldehyde (ureaform)". Canadian Journal of Microbiology. 43 (12): 1111–1117. doi:10.1139/m97-159.

External links

• Methylenediurea+deaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)