U.S. Route 69 (US 69) is a major north–south United States highway in the central United States. When it was first created, it was only 150 miles (241 km) long, but it has since been expanded into a Minnesota to Texas cross-country route. The highway's southern terminus is in Port Arthur, Texas at an intersection with State Highway 87. Its northern terminus is in Albert Lea, Minnesota at Minnesota State Highway 13.
Missouri Route 5 is the longest state highway in Missouri and the only Missouri state highway to traverse the entire state. To the north, it continues into Iowa as Iowa Highway 5 and to the south it enters Arkansas as Arkansas Highway 5 as part of a three state 650 mile highway 5. With only a few exceptions, it is mostly a two-lane for its entire length.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 413 is a highway in Missouri running between Route 13 in Springfield and Route 13 in Reeds Spring. It is an older alignment of Route 13 which was later rerouted. Except for two sections, the road runs concurrent with other designations for its entire length.
Route 39 is a two-lane highway in southwestern Missouri. Its northern terminus is at U.S. Route 54 between Collins and El Dorado Springs at the community of Cedar Springs; its southern terminus is at the Arkansas state line where it continues as Highway 221.
Route 245 is a short two-lane highway in southwest Missouri. Its northern terminus is at Route 32 about three miles (5 km) west of Fair Play; its southern terminus is at U.S. Route 160 about seven miles (11 km) east of Greenfield.
Route 267 is a short state highway in the St. Louis, Missouri area. Its northern terminus is at Broadway in south St. Louis; its southern terminus is at an intersection with U.S. Route 50 (US 50), US 61, and US 67, locally known as Lindbergh Boulevard and Lemay Ferry Road to the south. The route is locally known as Lemay Ferry Road.
Route 240 is a highway in the central part of Missouri. Its eastern terminus is at U.S. Route 40 about two miles (3 km) west of Columbia; its western terminus is at U.S. Route 65 in Marshall. Spur Route 240 connects the road with Rocheport.
Route 116 is a highway in northwestern Missouri. Its eastern terminus is at Route A in Braymer; its western terminus is at U.S. Route 59 in Rushville.
Route 202 is a short highway in extreme northern Missouri. It never leaves Schuyler County. Its northern terminus is at the Iowa state line where it continues as Iowa Highway 202; its southern terminus is at the intersection of U.S. Route 63 and U.S. Route 136 in Lancaster.
Route 157 is a short highway in Adair County, Missouri. Its northern terminus is at Route 6 west of Kirksville; its southern terminus is at Thousand Hills State Park. It runs less than five miles (8 km) and there are no towns on the highway.
Route 47 is a highway in eastern Missouri. Its northern terminus is at Route 79 near Winfield; its southern terminus is at U.S. Route 67 in Bonne Terre.
Route 190 is a highway in northern Missouri. Its eastern terminus is at U.S. Route 65 north of Chillicothe; its western terminus is at Route 146 west of Trenton.
Route 110 is a short highway in Jefferson County. Its eastern terminus is at U.S. Route 67 about six miles (10 km) east of De Soto; its western terminus is at Route 21 a few miles north of De Soto. De Soto and Olympian Village are the only cities on the route.
State Route 74 (SR 74) is a 108-mile-long (174 km) state highway that runs southeast-to-northwest through portions of Bibb, Monroe, Upson, Pike, Meriwether, Coweta, Fayette, and Fulton counties in the central part of the U.S. state of Georgia. The route connects the Macon and Fairburn, via Thomaston, Woodbury, and Peachtree City.
Kentucky Route 1974, also known as Tates Creek Road, stretches from New Circle Road at its northern terminus and proceeds southeast towards Spears. It has become a popular commuting route from points south, especially with recent housing development south of Man o' War Boulevard that stretches to Kentucky Route 1980. KY 1974 was widened from two to four lanes south of Man o' War Boulevard to KY 1980 in the late 1990s. It becomes a rural two-lane road with very light traffic to its southern terminus with KY 169, which leads to the Valley View Ferry.
Pennsylvania Route 281 is a 45.8-mile-long (73.7 km) state highway located in Fayette and Somerset counties in Pennsylvania. The southern terminus is the West Virginia state line near Markleysburg, where the road becomes West Virginia Route 26. The northern terminus is at U.S. Route 30 in Stoystown.
Pennsylvania Route 381 is a 49.3-mile-long (79.3 km) state highway located in Fayette, and Westmoreland counties in Pennsylvania, United States. The southern terminus is the West Virginia state line near Elliottsville, Pennsylvania, where it continues as Preston County Route 8 to its southern terminus at WV 26 in Brandonville, West Virginia. The northern terminus is at U.S. Route 30 (US 30) near Ligonier.
U.S. Route 219 (US 219) is a part of the U.S. Highway System that runs from Rich Creek, Virginia, to West Seneca, New York. From near Grantsville, Maryland north to Ebensburg, Pennsylvania, US 219 is Corridor N of the Appalachian Development Highway System. From Meyersdale, Pennsylvania to just south of Carrolltown, Pennsylvania, US 219 is a limited-access highway. From Carrolltown US 219 runs largely as a two-lane road to DuBois, Pennsylvania, through which it runs as Brady Street, and then returns to a two-lane road after a junction with Interstate 80. US 219 runs directly through the towns of Brockway, Ridgway, and Johnsonburg before reaching Wilcox, where PA Route 321 splits and heads for the town of Kane. US 219 continues north as a two-lane road until reaching Bradford, where it becomes a limited-access highway and remains so until reaching the New York border. On August 9, 2007, Pennsylvania State Transportation Secretary Allen D. Biehler unveiled four signs along US Route 219 that dedicated the portion of the route in Somerset County, Pennsylvania as the Flight 93 Memorial Highway.
U.S. Route 63 is the portion of a north-south highway that runs through the U.S. state of Missouri from the Arkansas state line near Thayer to the Iowa state line near Lancaster.
Route 11 south of Kirksville 
Route 156 near La Plata 
US 36 / Route 110 in Callao 
US 24 in Clifton Hill 
Route 129 in Roanoke 
Route 5 / Route 240 north of Fayette 
