Interstate 57 (I-57) is a north–south Interstate Highway in Missouri and Illinois that parallels the old Illinois Central Railroad for much of its route. It runs from Sikeston, Missouri, at I-55 to Chicago, Illinois, at I-94. I-57 essentially serves as a shortcut route for travelers headed between the South and Chicago, bypassing St. Louis, Missouri and Springfield, Illinois. Between the junction of I-55 and I-57 in Sikeston and the junction of I-55 and I-90/I-94 in Chicago, I-55 travels for 436 miles (702 km), while the combination of I-57 and I-94 is only 396 miles (637 km) long between the same two points. In fact, both the control cities on the overhead signs and the destination mileage signs reference Memphis along southbound I-57, even as far north as its northern origin at I-94 in Chicago. Likewise, at its southern end, Chicago is the control city listed for I-57 on signs on northbound I-55 south of Sikeston, even though I-55 also goes to Chicago. A southward extension of I-57 from its current southern terminus to Little Rock, Arkansas is currently in various stages of development.
Interstate 72 (I-72) is an Interstate Highway in the midwestern United States. Its western terminus is in Hannibal, Missouri, at an intersection with U.S. Route 61 (US 61); its eastern terminus is at Country Fair Drive in Champaign, Illinois. The route runs through the major cities of Decatur, Illinois, and Springfield, Illinois. In 2006, the Illinois General Assembly dedicated all of I-72 as Purple Heart Memorial Highway. The stretch between Springfield and Decatur is also called Penny Severns Memorial Expressway, and the section between mile 35 and the Mississippi River is known as the Free Frank McWorter Historic Highway.
Route 7 is a state highway with its northern terminus at U.S. Route 24 in northeast Independence and its southern terminus at Interstate 44 southeast of Richland. The section between Harrisonville and Clinton provides an important link for traffic between Springfield and Kansas City.
Route 95 is a highway in southern Missouri. Its northern terminus is at Route 32 at Lynchburg in Laclede County. Its southern terminus is at U.S. Route 160 at Lutie about 2.5 miles west of the Theodosia arm of Bull Shoals Lake in Ozark County.
Route 181 is a highway in southern Missouri. Its southern terminus is at US 160 in Gainesville in Ozark County. It passes through eastern Douglas County and reaches its northern terminus at Business U.S. Route 60 in Cabool in Texas County.
Route 19 is a long state highway in Missouri. Its northern terminus is at U.S. Route 61 in New London and its southern terminus is at U.S. Route 63 on the north side of Thayer. Route 19 is one of Missouri's original 1922 highways, though it initially had a northern terminus at Route 14 in Cuba and was later extended north.
Route 32 is a highway in Missouri. Its eastern terminus is at the Mississippi River near Ste. Genevieve; its western terminus is at U.S. Route 54 in El Dorado Springs. It is currently one of the longest highways in the state. Most of the highway east of Lebanon is hilly and curvy, passing through a large part of the Missouri Ozarks.
Route 267 is a short state highway in the St. Louis, Missouri area. Its northern terminus is at Broadway in south St. Louis; its southern terminus is at an intersection with U.S. Route 50 (US 50), US 61, and US 67, locally known as Lindbergh Boulevard and Lemay Ferry Road to the south. The route is locally known as Lemay Ferry Road.
Route 240 is a highway in the central part of Missouri. Its eastern terminus is at U.S. Route 40 about two miles (3 km) west of Columbia; its western terminus is at U.S. Route 65 in Marshall. Spur Route 240 connects the road with Rocheport.
Route 11 is a highway in the northern part of the U.S. state of Missouri. Its northern terminus is at Route 15 near Baring; its southern terminus is at U.S. Route 24 west of Brunswick. The northern half of the route runs more east–west than north–south.
Route 20 is a highway in central Missouri. Its eastern terminus is at U.S. Route 65 Business in Marshall; its western terminus is at Route 13 in Higginsville.
Route 157 is a short highway in Adair County, Missouri. Its northern terminus is at Route 6 west of Kirksville; its southern terminus is at Thousand Hills State Park. It runs less than five miles (8 km) and there are no towns on the highway.
Route 87 is a highway in central Missouri. Its southern terminus is at U.S. Route 54 in Eldon, and its northern terminus is at Route 5/240 in Glasgow. Parts of the road are overlapped by the Lewis and Clark Trail and Santa Fe Trail.
Route 124 is a highway in central Missouri. Its eastern terminus is at Route 22/151 in Centralia; its western terminus is at Route 240 east of Fayette.
Route 49 is a highway in eastern Missouri. Its northern terminus is at Route 19 in Cherryville, and its southern terminus is at U.S. Route 67 five miles (8 km) east of Williamsville.
Route 68 is a highway in central and southern Missouri. Its eastern terminus is at Route 19 in Salem; its western terminus is at U.S. Route 63 north of Rolla. Even though it is an even- numbered route, it tends to run more north–south than east–west.
Route 47 is a highway in eastern Missouri. Its northern terminus is at Route 79 near Winfield; its southern terminus is at U.S. Route 67 in Bonne Terre.
Route 92 is a highway in Platte and Clay counties in northwestern Missouri, United States. Its western terminus is a continuation of K-92 on the Centennial Bridge over the Missouri River at the Kansas state line, and the eastern terminus is at U.S. Route 69 in northern Excelsior Springs.
Route 123 is a highway in southwestern Missouri. Its northern terminus is at U.S. Route 54 in Weaubleau; its southern terminus is at U.S. Route 160 in Willard.
U.S. Route 67 is the portion of a north-south highway in Missouri that starts at the Arkansas state line south of Neelyville and ends at the Illinois state line northeast of West Alton.
Route 11 south of Kirksville 
Route 156 near La Plata 
US 36 / Route 110 in Callao 
US 24 in Clifton Hill 
Route 129 in Roanoke 
Route 5 / Route 240 north of Fayette 
