N-substituted formamide deformylase

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N-substituted formamide deformylase
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EC no. 3.5.1.91
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In enzymology, a N-substituted formamide deformylase (EC 3.5.1.91) is an enzyme that catalyzes the chemical reaction

N-benzylformamide + H2O formate + benzylamine

Thus, the two substrates of this enzyme are N-benzylformamide and H2O, whereas its two products are formate and benzylamine. [1]

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-benzylformamide amidohydrolase and is also called NfdA. The enzyme is produced by Arthrobacter pascens bacteria. [2]

Related Research Articles

Hydrolase is a class of enzymes that commonly perform as biochemical catalysts that use water to break a chemical bond, which typically results in dividing a larger molecule into smaller molecules. Some common examples of hydrolase enzymes are esterases including lipases, phosphatases, glycosidases, peptidases, and nucleosidases.

<span class="mw-page-title-main">Benzylamine</span> Chemical compound

Benzylamine is an organic chemical compound with the condensed structural formula C6H5CH2NH2 (sometimes abbreviated as PhCH2NH2 or BnNH2). It consists of a benzyl group, C6H5CH2, attached to an amine functional group, NH2. This colorless water-soluble liquid is a common precursor in organic chemistry and used in the industrial production of many pharmaceuticals. The hydrochloride salt was used to treat motion sickness on the Mercury-Atlas 6 mission in which NASA astronaut John Glenn became the first American to orbit the Earth.

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<span class="mw-page-title-main">Formamidase</span>

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<span class="mw-page-title-main">Peptide deformylase</span>

In enzymology, a peptide deformylase is an enzyme that removes the formyl group from the N terminus of nascent polypeptide chains in eubacteria, mitochondria and chloroplasts.

2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase (EC 3.5.1.102, ArfB) is an enzyme with systematic name 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase. This enzyme catalyses the following chemical reaction

N-formylmaleamate deformylase (EC 3.5.1.106, NicD) is an enzyme with systematic name N-formylmaleamic acid amidohydrolase. This enzyme catalyses the following chemical reaction

References

  1. Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M (September 2004). "Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning". Proceedings of the National Academy of Sciences of the United States of America. 101 (38): 13726–31. Bibcode:2004PNAS..10113726F. doi: 10.1073/pnas.0405082101 . PMC   518824 . PMID   15358859.
  2. Schomburg D, Schomburg I, Chang A, eds. (2009). "3.5.1.91 N-substituted formamide deformylase". Class 3 Hydrolases: EC 3.4.22-3.13. Springer Handbook of Enzymes (2nd ed.). Springer Science & Business Media. pp. 376–378. ISBN   9783540857051.