N1-acetylpolyamine oxidase

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N1-acetylpolyamine oxidase
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EC no. 1.5.3.13
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N1-acetylpolyamine oxidase (EC 1.5.3.13, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming). [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

(1) N1-acetylspermidine + O2 + H2O putrescine + 3-acetamidopropanal + H2O2
(2) N1-acetylspermine + O2 + H2O spermidine + 3-acetamidopropanal + H2O2

This enzyme also catalyses the reaction:

N1,N12-diacetylspermine + O2 + H2O N1-acetylspermidine + 3-acetamamidopropanal + H2O2.

Related Research Articles

In enzymology, a prenylcysteine oxidase (EC 1.8.3.5) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">SMOX</span> Enzyme

Spermine oxidase is an enzyme that in humans is encoded by the SMOX gene.

<span class="mw-page-title-main">PAOX</span> Protein-coding gene in the species Homo sapiens

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase is an enzyme that in humans is encoded by the PAOX gene.

Germacrene A alcohol dehydrogenase (EC 1.1.1.314) is an enzyme with systematic name germacra-1(10),4,11(13)-trien-12-ol:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction

Nucleoside oxidase (H2O2-forming) (EC 1.1.3.39) is an enzyme with systematic name nucleoside:oxygen 5'-oxidoreductase (H2O2-forming). This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Glycine oxidase</span> Class of enzymes

Glycine oxidase (EC 1.4.3.19) is an enzyme with systematic name glycine:oxygen oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Primary-amine oxidase</span>

Primary-amine oxidase, also known as semicarbazide-sensitive amine oxidase (SSAO), is an enzyme (EC 1.4.3.21) with the systematic name primary-amine:oxygen oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction

Polyamine oxidase (propane-1,3-diamine-forming) (EC 1.5.3.14, MPAO, maize PAO) is an enzyme with systematic name spermidine:oxygen oxidoreductase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction

N8-acetylspermidine oxidase (propane-1,3-diamine-forming) (EC 1.5.3.15) is an enzyme with systematic name N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction

Spermine oxidase (EC 1.5.3.16, PAOh1/SMO, AtPAO1, AtPAO4, SMO) is an enzyme with systematic name spermidine:oxygen oxidoreductase (spermidine-forming). This enzyme catalyses the following chemical reaction

Non-specific polyamine oxidase (EC 1.5.3.17, polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming). This enzyme catalyses the following chemical reaction

Menaquinol oxidase (H+-transporting) (EC 7.1.1.5, cytochrome aa3-600 oxidase) is an enzyme with systematic name menaquinol:O2 oxidoreductase (H+-transporting). This enzyme catalyses the following chemical reaction

Tyrosine N-monooxygenase (EC 1.14.13.41, tyrosine N-hydroxylase, CYP79A1) is an enzyme with systematic name L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

Methylsterol monooxygenase (EC 1.14.13.72, methylsterol hydroxylase, 4-methylsterol oxidase, 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)) is an enzyme with systematic name 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating). This enzyme catalyses the following chemical reaction

Epi-isozizaene 5-monooxygenase (EC 1.14.13.106, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating). This enzyme catalyses the following chemical reaction

Isoleucine N-monooxygenase (EC 1.14.13.117, CYP79D3, CYP79D4) is an enzyme with systematic name L-isoleucine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

Valine N-monooxygenase (EC 1.14.13.118, CYP79D1, CYP79D2) is an enzyme with systematic name L-valine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

Germacrene A hydroxylase (EC 1.14.13.123) is an enzyme with systematic name (+)-germacrene-A,NADPH:oxygen oxidoreductase (12-hydroxylating). This enzyme catalyses the following chemical reaction

Biflaviolin synthase (EC 1.14.21.7, CYP158A2, CYP 158A2, cytochrome P450 158A2) is an enzyme with systematic name flaviolin,NADPH:oxygen oxidoreductase. This enzyme catalyses the following chemical reaction

Cannabidiolic acid synthase is an enzyme with systematic name cannabigerolate:oxygen oxidoreductase . It is an oxidoreductase found in Cannabis sativa that catalyses the formation of cannabidiolate, a carboxylated precursor of cannabidiol.

References

  1. ↑ Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW (February 2003). "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion". The Biochemical Journal. 370 (Pt 1): 19–28. doi:10.1042/BJ20021779. PMC   1223169 . PMID   12477380.
  2. ↑ Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J (February 2005). "Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines". The Journal of Biological Chemistry. 280 (8): 6595–601. doi: 10.1074/jbc.M412788200 . PMID   15611107.
  3. ↑ Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA (July 2005). "Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity". Cancer Chemotherapy and Pharmacology. 56 (1): 83–90. doi:10.1007/s00280-004-0936-5. PMID   15791459.
  4. ↑ Wu T, Yankovskaya V, McIntire WS (June 2003). "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase". The Journal of Biological Chemistry. 278 (23): 20514–25. doi: 10.1074/jbc.M302149200 . PMID   12660232.
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