Peroxiredoxin 2

PRDX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QMV
Identifiers
Aliases	PRDX2 , HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
External IDs	OMIM: 600538 MGI: 109486 HomoloGene: 21182 GeneCards: PRDX2
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.13 Start 12,796,820 bp [1] End 12,801,800 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 C3|8 41.4 cM Start 85,696,216 bp [2] End 85,701,463 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spongy bone external globus pallidus pons right ventricle left adrenal gland superior vestibular nucleus embryo prefrontal cortex left ventricle ganglionic eminence Top expressed in superior frontal gyrus lip yolk sac motor neuron maxillary prominence aortic valve secondary oocyte neural tube ascending aorta trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity antioxidant activity peroxiredoxin activity peroxidase activity protein binding thioredoxin peroxidase activity Cellular component cytoplasm extracellular exosome cytosol Biological process regulation of apoptotic process negative regulation of apoptotic process hydrogen peroxide catabolic process cell redox homeostasis response to oxidative stress cellular response to oxidative stress removal of superoxide radicals respiratory burst involved in inflammatory response regulation of hydrogen peroxide metabolic process positive regulation of blood coagulation negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity response to lipopolysaccharide T cell proliferation hydrogen peroxide metabolic process negative regulation of T cell differentiation thymus development homeostasis of number of cells negative regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand leukocyte activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7001 21672 Ensembl ENSG00000167815 ENSMUSG00000005161 UniProt P32119 Q61171 RefSeq (mRNA) NM_181738 NM_005809 NM_181737 NM_011563 NM_001317385 RefSeq (protein) NP_005800 NP_001304314 NP_035693 Location (UCSC) Chr 19: 12.8 – 12.8 Mb Chr 8: 85.7 – 85.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene. ^{[5] [6]}

PRDX2 encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 0.27 nm (= 2.7 angstroms). Transcript variants encoding distinct isoforms have been identified for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000167815 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005161 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (Aug 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics. 26 (3): 602–6. doi:10.1016/0888-7543(95)80183-M. PMID   7607688.
6. "Entrez Gene: PRDX2 peroxiredoxin 2".

Further reading

• Yao Y, Taylor M, Davey F, RenY, Aiton J , Coote P, Chen X, Yan SD & Gunn-Moore FJ. (2007). "Interaction of Amyloid binding Alcohol Dehydrogenase/Aβ mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model". Molecular and Cellular Neuroscience. 35 (2): 377–82. doi:10.1016/j.mcn.2007.03.013. PMID   17490890. S2CID   2415008.
• Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID   1286667. S2CID   41855774.
• Shau H, Butterfield LH, Chiu R, Kim A (1994). "Cloning and sequence analysis of candidate human natural killer-enhancing factor genes". Immunogenetics. 40 (2): 129–34. doi:10.1007/BF00188176. PMID   8026862. S2CID   7778993.
• Chae HZ, Robison K, Poole LB, et al. (1994). "Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7017–21. Bibcode:1994PNAS...91.7017C. doi: 10.1073/pnas.91.15.7017 . PMC   44329 . PMID   8041738.
• Lim YS, Cha MK, Yun CH, et al. (1994). "Purification and characterization of thiol-specific antioxidant protein from human red blood cell: a new type of antioxidant protein". Biochem. Biophys. Res. Commun. 199 (1): 199–206. doi:10.1006/bbrc.1994.1214. PMID   8123012.
• Lim YS, Cha MK, Kim HK, Kim IH (1994). "The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions". Gene. 140 (2): 279–84. doi:10.1016/0378-1119(94)90558-4. PMID   8144038.
• Golaz O, Hughes GJ, Frutiger S, et al. (1994). "Plasma and red blood cell protein maps: update 1993". Electrophoresis. 14 (11): 1223–31. doi:10.1002/elps.11501401183. PMID   8313871. S2CID   21447827.
• Cha MK, Kim IH (1996). "Glutathione-linked thiol peroxidase activity of human serum albumin: a possible antioxidant role of serum albumin in blood plasma". Biochem. Biophys. Res. Commun. 222 (2): 619–25. doi:10.1006/bbrc.1996.0793. PMID   8670254.
• Ji H, Reid GE, Moritz RL, et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins". Electrophoresis. 18 (3–4): 605–13. doi:10.1002/elps.1150180344. PMID   9150948. S2CID   25454450.
• Wang ZM, Liu C, Dziarski R (2000). "Chemokines are the main proinflammatory mediators in human monocytes activated by Staphylococcus aureus, peptidoglycan, and endotoxin". J. Biol. Chem. 275 (27): 20260–7. doi: 10.1074/jbc.M909168199 . PMID   10751418.
• Cha MK, Yun CH, Kim IH (2000). "Interaction of human thiol-specific antioxidant protein 1 with erythrocyte plasma membrane". Biochemistry. 39 (23): 6944–50. doi:10.1021/bi000034j. PMID   10841776.
• Schröder E, Littlechild JA, Lebedev AA, et al. (2000). "Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution". Structure. 8 (6): 605–15. doi: 10.1016/S0969-2126(00)00147-7 . PMID   10873855.
• Harris JR, Schröder E, Isupov MN, et al. (2001). "Comparison of the decameric structure of peroxiredoxin-II by transmission electron microscopy and X-ray crystallography". Biochim. Biophys. Acta. 1547 (2): 221–34. doi:10.1016/s0167-4838(01)00184-4. PMID   11410278.
• Noh DY, Ahn SJ, Lee RA, et al. (2001). "Overexpression of peroxiredoxin in human breast cancer". Anticancer Res. 21 (3B): 2085–90. PMID   11497302.
• Kim SH, Fountoulakis M, Cairns N, Lubec G (2002). "Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down Syndrome". Protein Expression in Down Syndrome Brain. pp. 223–35. doi:10.1007/978-3-7091-6262-0_18. ISBN   978-3-211-83704-7. PMID   11771746.{{cite book}}: |journal= ignored (help)
• Rabilloud T, Heller M, Gasnier F, et al. (2002). "Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site". J. Biol. Chem. 277 (22): 19396–401. doi: 10.1074/jbc.M106585200 . PMID   11904290.
• Anahory T, Dechaud H, Bennes R, et al. (2002). "Identification of new proteins in follicular fluid of mature human follicles". Electrophoresis. 23 (7–8): 1197–202. doi:10.1002/1522-2683(200204)23:7/8<1197::AID-ELPS1197>3.0.CO;2-2. PMID   11981869. S2CID   24574562.
• Shen C, Nathan C (2002). "Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells". Mol. Med. 8 (2): 95–102. doi:10.1007/BF03402079. PMC   2039972 . PMID   12080185.
• Geiben-Lynn R, Kursar M, Brown NV, et al. (2003). "HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family". J. Biol. Chem. 278 (3): 1569–74. doi: 10.1074/jbc.M209964200 . PMID   12421812.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.