Peter Hotez | |
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Born | Peter Jay Hotez May 5, 1958 Hartford, Connecticut, U.S. |
Alma mater | |
Scientific career | |
Fields | Vaccinology, neglected tropical disease control, public policy, global health |
Institutions |
Peter Jay Hotez (born May 5, 1958) [1] is an American scientist, pediatrician, and advocate in the fields of global health, vaccinology, and neglected tropical disease control. He serves as founding dean of the National School of Tropical Medicine, Professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine, where he is also Director of the Texas Children's Hospital Center for Vaccine Development and Endowed Chair in Tropical Pediatrics. [2] [3] He also serves as a University Professor of Biology at Baylor University.
Hotez served previously as president of the American Society of Tropical Medicine and Hygiene [4] and is a founding Editor-in-Chief of PLOS Neglected Tropical Diseases . [5] He is also the co-director of Parasites Without Borders, a global nonprofit organization with a focus on those suffering from parasitic diseases in subtropical environments. [6]
Hotez was born in Hartford, Connecticut to a Jewish family. [1] His father Edward J. Hotez was a World War II veteran in the United States Navy. [7] [8]
Growing up in West Hartford, Hotez graduated from Hall High School. [1] In 1980, he earned a Bachelor of Arts in molecular biophysics and biochemistry magna cum laude (Phi Beta Kappa) from Yale University, in 1986 a Doctor of Philosophy from Rockefeller University, and in 1987 a Doctor of Medicine from Weill Cornell Medical College. [9] His doctoral dissertation and postdoctoral research were in hookworm molecular pathogenesis and vaccine development. [10]
Hotez was awarded postdoctoral positions in molecular parasitology and pediatric infectious diseases at Yale University School of Medicine, where he subsequently became an assistant professor in 1992 and an associate professor in 1995. His early research focused on the pathogenesis and molecular mechanisms of human hookworm infection that eventually led to his patented vaccine now in clinical trials, [11] [12] as well as a vaccine against schistosomiasis, also in clinical trials, [13] either of which could be the first successful vaccine for humans to protect against a multi-cellular parasite. [14]
From 2000 to 2011, Hotez served as Professor and Chair of the Department of Microbiology and Tropical Medicine (renamed in 2005 as the Department of Microbiology, Immunology, and Tropical Medicine) at the George Washington University. [15]
Following the World Health Organization's (WHO) Millennium Development Goals in 2000, Hotez, along with Drs. Alan Fenwick and David Molyneux, led a global effort to rename diseases then being termed simply "other diseases," as "neglected tropical diseases" (NTDs), and promoting the use of therapeutic/preventive chemotherapy through a combination of drugs called the "rapid-impact package." [16] Hotez has advocated for increased efforts to control NTDs since 2005 through publications and speaking engagements, helping to gain increased awareness resulting in a decrease of prevalence and disease burden in many areas. [17]
Hotez led the Sabin Vaccine Institute in Washington, D.C., as well as efforts to establish PLOS Neglected Tropical Diseases , the first online open access medical journal focused exclusively on neglected tropical diseases. [18]
In addition to continuing work on vaccines already in clinical trials for hookworm as of 2010 [11] and schistosomiasis, [13] Hotez led a team of researchers developing vaccines against other diseases including leishmaniasis, Chagas disease, SARS, and MERS, [19] As of 2020, he was also working in development of a Coronavirus vaccine. [20] With Maria Elena Bottazzi, he led the team that designed COVID-19 vaccine named Corbevax. [21]
Hotez has used his public profile on Twitter and other social media platforms to combat misinformation about the COVID-19 pandemic and about vaccines. He has appeared as an invited expert in a number of cable news and radio shows. [22] [23] [24] In an interview with the American Medical Association, Hotez noted that communicating clear messages about the ongoing pandemic is of vital importance in an environment that is rife with confusing and misleading messages. "We've been hearing either the sky was falling or there was no problem... the reality is more nuanced than that and that requires some explanation based on scientific principles." [25]
Hotez has warned that contrary to popular belief, more young adults than expected would be hospitalized due to the outbreak of COVID-19: "The message is that we've been trying to appeal to younger adults and have them shelter away and do the social distancing and explaining why they're at risk for transmitting the virus to vulnerable populations." [26] In 2020 he warned against optimistic COVID-19 vaccine timelines, arguing that rushing could cause problems, "potentially mak[ing] individuals worse and threaten[ing] vaccine development in the U.S." [27] On August 7, 2020, he said in a television interview that the US can expect to be affected by COVID-19 for "years and years" even after Americans are vaccinated. In that interview, he also blamed the federal government for not taking action to contain the spread of the virus. [28]
Like many other public health experts who used social media during the pandemic, Hotez was the target of online harassment. [29] He had already experienced significant prior harassment because of his vaccine advocacy, including at his lectures, receiving online threats, and being blamed for his daughter's autism. [30] In June 2023, he tweeted his concerns about Robert F. Kennedy Jr. sharing misinformation about vaccines on Joe Rogan's podcast. Rogan, Kennedy, and Twitter owner Elon Musk asked Hotez to participate in a debate on the podcast. Upon declining the invitation, Hotez was harassed by their fans, with anti-vaccine activist Alex Rosen confronting him at his home. [29] [31] [32] At around the same time, he had been the subject of attacks by followers of Steve Bannon and Tucker Carlson who had separately denigrated him. [33] In October 2023, he was given the inaugural Anthony Fauci Courage in Leadership Award from the Infectious Diseases Society of America for his efforts in combating anti-science. [34]
Hotez is the parent of an autistic daughter. In his 2018 book Vaccines Did Not Cause Rachel's Autism: My Journey As a Vaccine Scientist, Pediatrician, and Autism Dad he declared that vaccines did not cause his daughter´s autism.
Selected awards and memberships include:
In 2008, he was elected to membership in the Institute of Medicine of the National Academies. [46] He is an ambassador of the Paul G. Rogers Society for Global Health Research, a Fellow of the American Academy of Pediatrics (FAAP), a member of the World Health Organization Scientific and Technical Advisory Committee for WHO TDR (Special Programme on Tropical Diseases Research), [47] and in 2011, Hotez was appointed as a member of the National Institutes of Health (NIH) Council of Councils. [48] He is a member of the inaugural class of Fellows of the American Society of Tropical Medicine and Hygiene. [49]
He is a co-editor of Krugman's Infectious Diseases of Children, 11th Edition, [50] and co-editor of Manson's Tropical Diseases, 23rd Edition and Feigin and Cherry's Textbook of Pediatric Infectious Diseases, 7th Edition.
He is the co-author of the reference work called Parasitic Diseases, 5th Edition. [51]
Sir Peter Karel, Baron Piot is a Belgian-British microbiologist known for his research into Ebola and AIDS.
Tropical diseases are diseases that are prevalent in or unique to tropical and subtropical regions. The diseases are less prevalent in temperate climates, due in part to the occurrence of a cold season, which controls the insect population by forcing hibernation. However, many were present in northern Europe and northern America in the 17th and 18th centuries before modern understanding of disease causation. The initial impetus for tropical medicine was to protect the health of colonial settlers, notably in India under the British Raj. Insects such as mosquitoes and flies are by far the most common disease carrier, or vector. These insects may carry a parasite, bacterium or virus that is infectious to humans and animals. Most often disease is transmitted by an insect bite, which causes transmission of the infectious agent through subcutaneous blood exchange. Vaccines are not available for most of the diseases listed here, and many do not have cures.
Helminthiasis, also known as worm infection, is any macroparasitic disease of humans and other animals in which a part of the body is infected with parasitic worms, known as helminths. There are numerous species of these parasites, which are broadly classified into tapeworms, flukes, and roundworms. They often live in the gastrointestinal tract of their hosts, but they may also burrow into other organs, where they induce physiological damage.
The National Institute of Allergy and Infectious Diseases is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.
Tropical medicine is an interdisciplinary branch of medicine that deals with health issues that occur uniquely, are more widespread, or are more difficult to control in tropical and subtropical regions.
Hookworm infection is an infection by a type of intestinal parasite known as a hookworm. Initially, itching and a rash may occur at the site of infection. Those only affected by a few worms may show no symptoms. Those infected by many worms may experience abdominal pain, diarrhea, weight loss, and tiredness. The mental and physical development of children may be affected. Anemia may result.
Rolla Eugene Dyer was an American physician born in Delaware County, Ohio. Dyer received his B.A. in 1907 from Kenyon College in Gambier, Ohio, and his M.D. in 1914 from the University of Texas. He joined the U.S. Public Health Service in 1916.
Paul Allan Offit is an American pediatrician specializing in infectious diseases, vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine. Offit is the Maurice R. Hilleman Professor of Vaccinology, professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania, former chief of the Division of Infectious Diseases (1992–2014), and the director of the Vaccine Education Center at the Children's Hospital of Philadelphia.
Neglected tropical diseases (NTDs) are a diverse group of tropical infections that are common in low-income populations in developing regions of Africa, Asia, and the Americas. They are caused by a variety of pathogens, such as viruses, bacteria, protozoa, and parasitic worms (helminths). These diseases are contrasted with the "big three" infectious diseases, which generally receive greater treatment and research funding. In sub-Saharan Africa, the effect of neglected tropical diseases as a group is comparable to that of malaria and tuberculosis. NTD co-infection can also make HIV/AIDS and tuberculosis more deadly.
Hookworm vaccine is a vaccine against hookworm. No effective vaccine for the disease in humans has yet been developed. Hookworms, parasitic nematodes transmitted in soil, infect approximately 700 million humans, particularly in tropical regions of the world where endemic hookworms include Ancylostoma duodenale and Necator americanus. Hookworms feed on blood and those infected with hookworms may develop chronic anaemia and malnutrition. Helminth infection can be effectively treated with benzimidazole drugs, and efforts led by the World Health Organization have focused on one to three yearly de-worming doses in schools because hookworm infections with the heaviest intensities are most common in school-age children. However, these drugs only eliminate existing adult parasites and re-infection can occur soon after treatment. School-based de-worming efforts do not treat adults or pre-school children and concerns exist about drug resistance developing in hookworms against the commonly used treatments, thus a vaccine against hookworm disease is sought to provide more permanent resistance to infection.
The American Society of Tropical Medicine and Hygiene (ASTMH) is an Arlington, Virginia-based non-profit organization of scientists, clinicians, students and program professionals whose longstanding mission is to promote global health through the prevention and control of infectious and other diseases that disproportionately afflict the global poor. ASTMH members work in areas of research, health care and education that encompass laboratory science, international field studies, clinical care and country-wide programs of disease control. The current organization was formed in 1951 with the amalgamation of the American Society of Tropical Medicine, founded in 1903, and the National Malaria Society, founded in 1941.
Soil-transmitted helminthiasis is a type of worm infection (helminthiasis) caused by different species of roundworms. It is caused specifically by those worms which are transmitted through soil contaminated with faecal matter and are therefore called soil-transmitted helminths. Three types of soil-transmitted helminthiasis can be distinguished: ascariasis, hookworm infection and whipworm infection. These three types of infection are therefore caused by the large roundworm A. lumbricoides, the hookworms Necator americanus or Ancylostoma duodenale and by the whipworm Trichuris trichiura.
Edward Thomas Ryan is an American microbiologist, immunologist, and physician at Harvard University and Massachusetts General Hospital. Ryan served as president of the American Society of Tropical Medicine and Hygiene from 2009 to 2010. Ryan is Professor of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health, Professor of Medicine at Harvard Medical School, and Director of Global Infectious Diseases at the Massachusetts General Hospital. Ryan's research and clinical focus has been on infectious diseases associated with residing in, immigrating from, or traveling through resource-limited areas. Ryan is a Fellow of the American Society of Microbiology, the American Society of Tropical Medicine and Hygiene, the American College of Physicians, and the Infectious Diseases Society of America.
Gagandeep Kang FRS is an Indian microbiologist and virologist who has been leading the work on enteric diseases, diarrheal infections and disease surveillance at the Bill & Melinda Gates Foundation since 2023.
Maria Elena Bottazzi is an American microbiologist. As of 2024 she is associate dean of the National School of Tropical Medicine at Baylor College of Medicine, as well as Distinguished Professor of Biology at Baylor University, Waco, Texas. She is editor-in-chief of Springer's Current Tropical Medicine Reports. She and Peter Hotez led the team that designed COVID-19 vaccine Corbevax.
Sabin Vaccine Institute, located in Washington, D.C., is a nonprofit organization promoting global vaccine development, availability, and use. Through its work, Sabin hopes to reduce human suffering by preventing the spread of vaccine-preventable, communicable disease in humans through herd immunity and mitigating the poverty caused by these diseases.
Oluwatoyin (Toyin) Asojo currently Associate Director for Diversity, Equity, Inclusion, and Belonging at Dartmouth Cancer Center was formerly Associate Professor and chair of the Department of Chemistry and Biochemistry at Hampton University. She was formerly an Associate Professor of Pediatrics-Tropical medicine at the Baylor College of Medicine. She works at "the interface of math, chemistry, biology, computation." She is a crystallographer and interested in structural studies of proteins from neglected tropical disease pathogens.
John Andrew Crump MB ChB, MD, DTM&H, FRACP, FRCPA, FRCP is a New Zealand-born infectious diseases physician, medical microbiologist, and epidemiologist. He is Professor of Medicine, Pathology, and Global Health at the University of Otago and an adjunct professor of medicine, Pathology, and Global Health at Duke University. He serves as inaugural co-director of the Otago Global Health Institute, one of the university's research centres. His primary research interest is fever in the tropics, focusing on invasive bacterial diseases and bacterial and viral zoonoses.
Scott Halstead is an American physician-scientist, virologist and epidemiologist known for his work in the fields of tropical medicine and vaccine development. He is considered one of the world's foremost authorities on viruses transmitted by mosquitoes, including Dengue, Japanese encephalitis, chikungunya and Zika. He was one of the first researchers to identify the phenomenon known as antibody-dependent enhancement (ADE), where the antibodies generated from a first dengue infection can sometimes worsen the symptoms from a second infection.
David R. Murdoch is a New Zealand academic specialising in paediatric infectious diseases, especially pneumonia. He has also worked on Legionnaires' disease and has advised the Oxford University vaccine group and the New Zealand government on COVID-19. Murdoch served as Vice-Chancellor of the University of Otago between February 2022 and June 2023.