Phosphoserine transaminase

Phosphoserine transaminase
Identifiers
EC no.	2.6.1.52
CAS no.	9030-90-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Phosphoserine transaminase (EC 2.6.1.52, PSAT, phosphoserine aminotransferase, 3-phosphoserine aminotransferase, hydroxypyruvic phosphate-glutamic transaminase, L-phosphoserine aminotransferase, phosphohydroxypyruvate transaminase, phosphohydroxypyruvic-glutamic transaminase, 3-O-phospho-L-serine:2-oxoglutarate aminotransferase, SerC, PdxC, 3PHP transaminase) is an enzyme with systematic name O-phospho-L-serine:2-oxoglutarate aminotransferase. ^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

(1) O-phospho-L-serine + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ 3-phosphonooxypyruvate + L-glutamate

(2) 4-phosphonooxy-L-threonine + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate

This enzyme is a pyridoxal-phosphate protein.

See also

• PSAT1

References

1. Hirsch H, Greenberg DM (May 1967). "Studies on phosphoserine aminotransferase of sheep brain". The Journal of Biological Chemistry. 242 (9): 2283–7. doi: 10.1016/S0021-9258(18)96047-3 . PMID   6022873.
2. Pizer LI (December 1963). "The pathway and control of serine biosynthesis in Escherichia coli". The Journal of Biological Chemistry. 238 (12): 3934–44. doi: 10.1016/S0021-9258(18)51809-3 . PMID   14086727.
3. Zhao G, Winkler ME (January 1996). "A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria". Journal of Bacteriology. 178 (1): 232–9. doi:10.1128/jb.178.1.232-239.1996. PMC   177644 . PMID   8550422.
4. Drewke C, Klein M, Clade D, Arenz A, Müller R, Leistner E (July 1996). "4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis". FEBS Letters. 390 (2): 179–82. Bibcode:1996FEBSL.390..179D. doi: 10.1016/0014-5793(96)00652-7 . PMID   8706854.
5. Zhao G, Winkler ME (January 1996). "4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12". FEMS Microbiology Letters. 135 (2–3): 275–80. doi: 10.1111/j.1574-6968.1996.tb08001.x . PMID   8595869.

External links

• Phosphoserine+transaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)