Poorly differentiated thyroid cancer

Poorly differentiated thyroid carcinoma
Other names	PDTC
Specialty	Oncology

Poorly differentiated thyroid carcinoma is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers. ^[1]

Histopathology

• Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern
• Round or oval nests (insulae) or in trabeculae.
• Solid growth and presence of microfollicles, some of which contain dense colloid.
• Extrathyroidal extension and blood vessel invasion
• Foci of necrosis,
• Larger than 5 cm in greatest diameter at diagnosis

Epidemiology

• PDTC affects predominantly females about 55 years of age

References

1. Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M, Sobrinho-Simoes M, Bussolati G, Rosai J (2007). "Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach". Am J Surg Pathol. 31 (8): 1256–64. doi:10.1097/PAS.0b013e3180309e6a. PMID   17667551. S2CID   41666642.