Ron Heeren

Last updated
Ron M.A. Heeren
Ron Heeren.jpg
Ron Heeren in 2017
Born1965
Tilburg, Netherlands
NationalityDutch
Alma materUniversity of Amsterdam
AwardsHans Fisher Fellowship; Thomson Medal of IMSF; NWO-Physics Valorisation Prize; Brightlands Convention Award; Robert Feulgen lecturer, Society for Histochemistry; Distinguished Wiley Visiting Scientist award;
Scientific career
FieldsImaging Mass Spectrometry

Ron M.A. Heeren (born 1965, Tilburg) is a Dutch scientist in mass spectrometry imaging. He is currently a distinguished professor at Maastricht University and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry.

Contents

Scientific career

Heeren obtained a PhD degree in Technical Physics at the University of Amsterdam in 1992 under the supervision of Aart Kleyn.

He led a FOM-AMOLF research group on macromolecular ion physics and biomolecular imaging mass spectrometry (1995–2014). He was also professor at the chemistry faculty of Utrecht University in 2001–2019.

Between 1995 and 2015, he worked on new approaches towards high spatial resolution and high-throughput molecular imaging mass spectrometry using secondary ion mass spectrometry (SIMS) and matrix-assisted laser desorption and ionization (MALDI).

Heeren has coauthored over 300 peer-reviewed articles, which have been cited over 12,600 times (Google Scholar). [1]

Research

Heeren’s academic research interests are fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry–based proteomic imaging techniques for the life sciences.

During his postdoctoral fellowship, he worked on the development of innovative ion sources, vacuums systems, data acquisition systems and novel temperature-controlled ion cyclotron resonance cells. He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions. [2] [3] [4]  These methods were deployed to investigate their role in the determination of dissociation pathways of biomolecular systems. [5] [6]

As a project leader (1995–1997), Heeren led the application of high-resolution MS (FTICR-MS, FTIR imaging spectroscopy and SIMS) to the field of conservation science. He discovered and identified saponified pigment particulates in so-called protrusions in Rembrandt’s “The Anatomy Lesson of Dr. Nicolaes Tulp” in collaboration with the Mauritshuis museum in The Hague. [7] [8] [9]

Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. One such detector, the Medipix detector has been adapted to enable microscope-mode imaging mass spectrometry [10] for biomolecules to enable combined high-throughput and high-resolution molecular imaging using MALDI and SIMS.

Professional activities

From 2008 to 2013, Heeren was the research director for emerging technologies at the Netherlands Proteomics Centre. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University. [11] He was president of the Dutch Society of Mass Spectrometry between 2001–2005. [12] He is one of the founding members of the Mass Spectrometry Imaging Society, and was elected its president in 2017. [13]

Commercialization

Heeren holds 7 patents and has established two spin-off companies, Omics2Image/ASI and the Dutch Screening Group. In 2019, he was awarded the NWO Valorisation Prize in Physics. [14] [15]

Awards

Most cited publications

  1. Ščupáková, Klára; Dewez, Frédéric; Walch, Axel K.; Heeren, Ron M. A.; Balluff, Benjamin (2020-08-17). "Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging". Angewandte Chemie International Edition. 59 (40): 17447–17450. doi:10.1002/anie.202007315. ISSN   1433-7851. PMC   7540554 . PMID   32668069.
  2. Ellis, Shane R.; Paine, Martin R. L.; Eijkel, Gert B.; Pauling, Josch K.; Husen, Peter; Jervelund, Mark W.; Hermansson, Martin; Ejsing, Christer S.; Heeren, Ron M. A. (2018-05-21). "Automated, parallel mass spectrometry imaging and structural identification of lipids". Nature Methods. 15 (7): 515–518. doi:10.1038/s41592-018-0010-6. ISSN   1548-7091. PMID   29786091. S2CID   29162438.
  3. Bruinen, Anne L.; Fisher, Gregory L.; Balez, Rachelle; van der Sar, Astrid M.; Ooi, Lezanne; Heeren, Ron M. A. (2018-06-12). "Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry". Journal of the American Society for Mass Spectrometry. 29 (8): 1571–1581. Bibcode:2018JASMS..29.1571B. doi:10.1007/s13361-018-1979-x. ISSN   1044-0305. PMC   6060986 . PMID   29949055.
  4. Ščupáková, Klára; Soons, Zita; Ertaylan, Gökhan; Pierzchalski, Keely A.; Eijkel, Gert B.; Ellis, Shane R.; Greve, Jan W.; Driessen, Ann; Verheij, Joanne; De Kok, Theo M.; Olde Damink, Steven W. M. (17 April 2018). "Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity". Analytical Chemistry. 90 (8): 5130–5138. doi:10.1021/acs.analchem.7b05215. ISSN   1520-6882. PMC   5906754 . PMID   29570976.
  5. Ellis, S. R.; Soltwisch, J.; Paine, M. R. L.; Dreisewerd, K.; Heeren, R. M. A. (2017). "Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids". Chemical Communications. 53 (53): 7246–7249. doi:10.1039/c7cc02325a. ISSN   1359-7345. PMID   28573274. S2CID   4627246.
  6. Ogrinc Potočnik, Nina; Porta, Tiffany; Becker, Michael; Heeren, Ron M. A.; Ellis, Shane R. (2015-10-28). "Use of advantageous, volatile matrices enabled by next-generation high-speed matrix-assisted laser desorption/ionization time-of-flight imaging employing a scanning laser beam" . Rapid Communications in Mass Spectrometry. 29 (23): 2195–2203. Bibcode:2015RCMS...29.2195O. doi:10.1002/rcm.7379. ISSN   0951-4198. PMID   26522310.
  7. Ellis, Shane R.; Jungmann, Julia H.; Smith, Donald F.; Soltwisch, Jens; Heeren, Ron M. A. (2013-10-18). "Enhanced detection of high-mass proteins by using an active pixel detector". Angewandte Chemie International Edition in English. 52 (43): 11261–11264. doi:10.1002/anie.201305501. ISSN   1521-3773. PMID   24039122.
  8. Jungmann, Julia H.; Smith, Donald F.; MacAleese, Luke; Klinkert, Ivo; Visser, Jan; Heeren, Ron M. A. (2012-07-27). "Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector". Journal of the American Society for Mass Spectrometry. 23 (10): 1679–1688. arXiv: 1305.5437 . Bibcode:2012JASMS..23.1679J. doi:10.1007/s13361-012-0444-5. ISSN   1044-0305. PMID   22836864. S2CID   13480751.
  9. Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector" . Analytical Chemistry. 83 (20): 7888–7894. doi:10.1021/ac2017629. ISSN   0003-2700. PMID   21882854.
  10. Chughtai, Kamila; Heeren, Ron M. A. (2010-05-12). "Mass Spectrometric Imaging for Biomedical Tissue Analysis". Chemical Reviews. 110 (5): 3237–3277. doi:10.1021/cr100012c. ISSN   0009-2665. PMC   2907483 . PMID   20423155.

References

  1. ↑ "Ron M.A. Heeren". scholar.google.nl. Retrieved 2020-12-18.
  2. ↑ Heeren, Ron M. A.; Vékey, Károly (1998-09-15). <1175::aid-rcm305>3.0.co;2-l "A novel method to determine collisional energy transfer efficiency by Fourier transform ion cyclotron resonance mass spectrometry" . Rapid Communications in Mass Spectrometry. 12 (17): 1175–1181. doi:10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l. ISSN   0951-4198.
  3. ↑ Drahos, null; Heeren, null; Collette, null; De Pauw E, null; Vekey, null (December 1999). "Thermal energy distribution observed in electrospray ionization". Journal of Mass Spectrometry. 34 (12): 1373–1379. Bibcode:1999JMSp...34.1373D. doi:10.1002/(SICI)1096-9888(199912)34:12<1373::AID-JMS907>3.0.CO;2-#. ISSN   1096-9888. PMID   10587635.
  4. ↑ Guo, Xinghua; Duursma, Marc C.; Kistemaker, Piet G.; Nibbering, Nico M. M.; Vekey, Karoly; Drahos, Laszlo; Heeren, Ron M. A. (June 2003). "Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry". Journal of Mass Spectrometry. 38 (6): 597–606. Bibcode:2003JMSp...38..597G. doi:10.1002/jms.480. ISSN   1076-5174. PMID   12827629.
  5. ↑ Koster, Sander; Duursma, Marc C.; Boon, Jaap J.; Nielen, Michel W. F.; de Koster, Chris G.; Heeren, Ron M. A. (2000). <739::aid-jms3>3.0.co;2-# "Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a Fourier transform ion cyclotron resonance mass spectrometer" . Journal of Mass Spectrometry. 35 (6): 739–748. Bibcode:2000JMSp...35..739K. doi:10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#. ISSN   1076-5174. PMID   10862127.
  6. ↑ Kleinnijenhuis, Anne J.; Duursma, Marc C.; Breukink, Eefjan; Heeren, Ron M. A.; Heck, Albert J. R. (2003-07-01). "Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation". Analytical Chemistry. 75 (13): 3219–3225. doi:10.1021/ac0263770. hdl: 1874/14955 . ISSN   0003-2700. PMID   12964772. S2CID   17450996.
  7. ↑ Heeren, Ron M. A.; Boon, Jaap J.; Noble, Petria; Wadum, Jørgen (1999). "Integrating imaging FTIR and secondary ion mass spectrometry for the analysis of embedded paint cross-sections". ICOM-CC Triennial Meeting (12th), Lyon, 29 August-3 September 1999: Preprints.: 228–233.
  8. ↑ "Recitative after Rembrandt's "The Anatomy Lesson of Dr. Nicolaes Tulp"" , 90 Miles, University of Pittsburgh Press, pp. 78–79, 2005-03-23, doi:10.2307/j.ctvthhc5r.38, ISBN   978-0-8229-8033-9 , retrieved 2020-12-18
  9. ↑ Van Der Weerd, J.; Brammer, H.; Boon, J. J.; Heeren, R. M. A. (March 2002). "Fourier Transform Infrared Microscopic Imaging of an Embedded Paint Cross-Section" . Applied Spectroscopy. 56 (3): 275–283. Bibcode:2002ApSpe..56Q.275V. doi:10.1366/0003702021954683. ISSN   0003-7028. S2CID   95454503.
  10. ↑ Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector" . Analytical Chemistry. 83 (20): 7888–7894. doi:10.1021/ac2017629. ISSN   0003-2700. PMID   21882854.
  11. ↑ "Maastricht University Magazine October 2014". Issuu. 14 October 2014. Retrieved 2020-12-18.
  12. ↑ "History". NVMS. Retrieved 2020-12-18.
  13. ↑ "Mass Spectrometry Imaging Society – MS Imaging". ms-imaging.org. Retrieved 2020-12-18.
  14. ↑ "NWO Physics Valorisation Prize 2019 - Ron Heeren - YouTube". www.youtube.com. 8 January 2020. Retrieved 2020-12-18.
  15. ↑ "NWO Physics Valorisation Prize goes to Ron Heeren from Maastricht University | NWO". www.nwo.nl. Retrieved 2020-12-18.
  16. ↑ "Heeren, Ron M.A. - Institute for Advanced Study (IAS)". www.ias.tum.de (in German). Retrieved 2020-12-18.
  17. ↑ Maastricht, Minderbroedersberg 4-6 6211 LK (25 May 2020). "Thomson Medal 2020 awarded to Ron Heeren". www.maastrichtuniversity.nl. Retrieved 2020-12-18.{{cite web}}: CS1 maint: numeric names: authors list (link)
  18. ↑ "International Mass Spectronomy Foundation". www.imss.nl. Retrieved 2020-12-18.
  19. ↑ Redactie (2019-03-27). "Uitreiking Brightlands Convention Award 2018". Conference Matters (in Dutch). Retrieved 2020-12-18.
  20. ↑ "Society for Histochemistry". www.histochemistry.eu. Retrieved 2020-12-18.
  21. ↑ "Press release: Omics2Image wins Venture Challenge Spring 2013" (PDF).
  22. ↑ "iDirector interview with Ron Heeren - YouTube". www.youtube.com. 28 June 2012. Retrieved 2020-12-18.
  23. ↑ "New EMSL Visiting Scientists Named".
  24. ↑ "Rapid Communications in Mass Spectrometry". Wiley Online Library. Retrieved 2020-12-18.
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