Distinguished Contribution in Mass Spectrometry (1999) Thomson Medal (2000) Chemical Pioneer Award (2007) William H. Nichols Medal (2012), given by the New York Section of the American Chemical Society Pittsburgh Analytical Chemistry Award (2012), given by the Society for Analytical Chemists of Pittsburgh
Fourier-transform ion cyclotron resonance mass spectrometry is a type of mass analyzer for determining the mass-to-charge ratio (m/z) of ions based on the cyclotron frequency of the ions in a fixed magnetic field. The ions are trapped in a Penning trap, where they are excited to a larger cyclotron radius by an oscillating electric field orthogonal to the magnetic field. After the excitation field is removed, the ions are rotating at their cyclotron frequency in phase. These ions induce a charge on a pair of electrodes as the packets of ions pass close to them. The resulting signal is called a free induction decay (FID), transient or interferogram that consists of a superposition of sine waves. The useful signal is extracted from this data by performing a Fourier transform to give a mass spectrum.
The history of mass spectrometry has its roots in physical and chemical studies regarding the nature of matter. The study of gas discharges in the mid 19th century led to the discovery of anode and cathode rays, which turned out to be positive ions and electrons. Improved capabilities in the separation of these positive ions enabled the discovery of stable isotopes of the elements. The first such discovery was with the element neon, which was shown by mass spectrometry to have at least two stable isotopes: 20Ne and 22Ne. Mass spectrometers were used in the Manhattan Project for the separation of isotopes of uranium necessary to create the atomic bomb.
JEOL, Ltd. is a major developer and manufacturer of electron microscopes and other scientific instruments, industrial equipment and medical equipment.
Herbert Sander Gutowsky was an American chemist who was a Professor of Chemistry at the University of Illinois Urbana-Champaign. Gutowsky was the first to apply nuclear magnetic resonance (NMR) methods to the field of chemistry. He used nuclear magnetic resonance spectroscopy to determine the structure of molecules. His pioneering work developed experimental control of NMR as a scientific instrument, connected experimental observations with theoretical models, and made NMR one of the most effective analytical tools for analysis of molecular structure and dynamics in liquids, solids, and gases, used in chemical and medical research, His work was relevant to the solving of problems in chemistry, biochemistry, and materials science, and has influenced many of the subfields of more recent NMR spectroscopy.
Robert Graham Cooks is the Henry Bohn Hass Distinguished Professor of Chemistry in the Aston Laboratories for Mass Spectrometry at Purdue University. He is an ISI Highly Cited Chemist, with over 1,000 publications and an H-index of 134.
Jesse L. Beauchamp is the Charles and Mary Ferkel Professor of Chemistry at the California Institute of Technology.
Christie G. Enke is a United States academic chemist who made pioneering contributions to the field of analytical chemistry.
Scott A. McLuckey is an American chemist, the John A. Leighty Distinguished Professor of Chemistry at Purdue University. His research concerns the formation of ionized versions of large biomolecules, mass spectrometry of these ions, and ion-ion reactions.
Michael L. Gross is Professor of Chemistry, Medicine, and Immunology, at Washington University in St. Louis. He was formerly Professor of Chemistry at the University of Nebraska-Lincoln from 1968–1994. He is recognized for his contributions to the field of mass spectrometry and ion chemistry. He is credited with the discovery of distonic ions, chemical species containing a radical and an ionic site on different atoms of the same molecule.
Instrumental analysis is a field of analytical chemistry that investigates analytes using scientific instruments.
Richard Dale Smith is a chemist and a Battelle Fellow and Chief Scientist within the Biological Sciences Division, as well as the Director of Proteomics Research at the Pacific Northwest National Laboratory (PNNL). Dr. Smith is also Director of the NIH Proteomics Research Resource for Integrative Biology, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member at the University of Idaho and the Department of Molecular Microbiology & Immunology, Oregon Health & Science University. He is the author or co-author of approximately 1100 peer-reviewed publications and has been awarded 70 US patents.
Catherine Clarke Fenselau is an American scientist who was the first trained mass spectrometrist on the faculty of an American medical school; she joined Johns Hopkins School of Medicine in 1968. She specializes in biomedical applications of mass spectrometry. She has been recognized as an outstanding scientist in the field of bioanalytical chemistry because of her work using mass spectrometry to study biomolecules.
Petroleomics is the identification of the totality of the constituents of naturally occurring petroleum and crude oil using high resolution mass spectrometry. In addition to mass determination, petroleomic analysis sorts the chemical compounds into heteroatom class, type. The name is a combination of petroleum and -omics.
Cynthia Larive is an American scientist and academic administrator serving as the chancellor of University of California, Santa Cruz. Larive's research focuses on nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry. She was previously a professor of chemistry and provost and executive vice chancellor at the University of California, Riverside. She is a fellow of AAAS, IUPAC and ACS, associate editor for the ACS journal Analytical Chemistry and editor of the Analytical Sciences Digital Library.
John Michael Ramsey is an American analytical chemist at the University of North Carolina at Chapel Hill. He currently holds the position of Minnie N. Goldby Distinguished Professor of Chemistry. His current research with the university focuses on microscale and nanoscale devices such as microchip electrospray, microscale Ion trap mass spectrometers, and microfluidic point of care devices. He is ranked #2 in the "Giants of Nano" field on The Analytical Scientist Power List.
Kristina Håkansson is an analytical chemist known for her contribution in Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry for biomolecular identification and structural characterization. Currently, she holds the position of Professor of Chemistry at University of Michigan. Her research focuses on mass spectrometry, primarily identification and characterization of protein posttranslational modifications by complementary fragmentation techniques such as electron-capture dissociation (ECD)/negative ion ECD (niECD) and infrared multiphoton dissociation (IRMPD) at low (femtomole) levels.
Martin F. Jarrold is a physical and analytical chemist known for contributions to ion-mobility spectrometry, heat capacity measurements of metal clusters, and charge detection mass spectrometry. Martin is the Robert & Marjorie Mann Chair in the Department of Chemistry at Indiana University.
Melvin Barnett Comisarow is a Canadian physicist and analytical chemist who co-invented the Fourier-transform ion cyclotron resonance technique of Mass spectroscopy, together with Alan G. Marshall, at the University of British Columbia. Comisarow was born in Alberta to a Ukrainian-Canadian family, and earned his bachelor's degree at the University of Alberta, 1963, before obtaining his PhD at Case Western Reserve University, under the supervision of George Andrew Olah in 1969, and subsequently a postdoc with John D. Baldeschwieler at Stanford University. His first academic appointment was at the University of British Columbia, where he subsequently stayed until retirement.
Ron M.A. Heeren is a Dutch scientist in mass spectrometry imaging. He is currently a distinguished professor at Maastricht University and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry.
Charles Wilkins is a Distinguished Professor of Chemistry and Biochemistry at the University of Arkansas and the founding Director of the University of Arkansas Statewide Mass Spectrometry Facility. With Michael Gross, he built the second Fourier transform ion cyclotron resonance mass spectrometer and they were the first to use it for analytical applications.
This page is based on this Wikipedia article Text is available under the CC BY-SA 4.0 license; additional terms may apply. Images, videos and audio are available under their respective licenses.
