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Fourier-transform ion cyclotron resonance mass spectrometry is a type of mass analyzer (or mass spectrometer) for determining the mass-to-charge ratio (m/z) of ions based on the cyclotron frequency of the ions in a fixed magnetic field. The ions are trapped in a Penning trap (a magnetic field with electric trapping plates), where they are excited (at their resonant cyclotron frequencies) to a larger cyclotron radius by an oscillating electric field orthogonal to the magnetic field. After the excitation field is removed, the ions are rotating at their cyclotron frequency in phase (as a "packet" of ions). These ions induce a charge (detected as an image current) on a pair of electrodes as the packets of ions pass close to them. The resulting signal is called a free induction decay (FID), transient or interferogram that consists of a superposition of sine waves. The useful signal is extracted from this data by performing a Fourier transform to give a mass spectrum.
Infrared multiple photon dissociation (IRMPD) is a technique used in mass spectrometry to fragment molecules in the gas phase usually for structural analysis of the original (parent) molecule.
The history of mass spectrometry has its roots in physical and chemical studies regarding the nature of matter. The study of gas discharges in the mid 19th century led to the discovery of anode and cathode rays, which turned out to be positive ions and electrons. Improved capabilities in the separation of these positive ions enabled the discovery of stable isotopes of the elements. The first such discovery was with the element neon, which was shown by mass spectrometry to have at least two stable isotopes: 20Ne and 22Ne. Mass spectrometers were used in the Manhattan Project for the separation of isotopes of uranium necessary to create the atomic bomb.
Alan G. Marshall is an American analytical chemist who has devoted his scientific career to developing a scientific technique known as Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry, which he co-invented.
David E. Clemmer is an analytical chemist and the Distinguished Professor and Robert and Marjorie Mann Chair of Chemistry at Indiana University in Bloomington, Indiana, where he leads the Clemmer Group. Clemmer develops new scientific instruments for ion mobility mass spectrometry (IMS/MS), including the first instrument for nested ion-mobility time-of-flight mass spectrometry. He has received a number of awards, including the Biemann Medal in 2006 "for his pioneering contributions to the integration of ion mobility separations with a variety of mass spectrometry technologies."
Peter B. Armentrout is a researcher in thermochemistry, kinetics, and dynamics of simple and complex chemical reactions. He is a Chemistry Professor at the University of Utah.
Scott A. McLuckey is an American chemist, the John A. Leighty Distinguished Professor of Chemistry at Purdue University. His research concerns the formation of ionized versions of large biomolecules, mass spectrometry of these ions, and ion-ion reactions.
Michael L. Gross is Professor of Chemistry, Medicine, and Immunology, at Washington University in St. Louis. He was formerly Professor of Chemistry at the University of Nebraska-Lincoln from 1968–1994. He is recognized for his contributions to the field of mass spectrometry and ion chemistry. He is credited with the discovery of distonic ions, chemical species containing a radical and an ionic site on different atoms of the same molecule.
Instrumental analysis is a field of analytical chemistry that investigates analytes using scientific instruments.
Richard Dale Smith is a chemist and a Battelle Fellow and chief scientist within the biological sciences division, as well as the director of proteomics research at the Pacific Northwest National Laboratory (PNNL). Smith is also director of the NIH Proteomics Research Resource for Integrative Biology, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member at the University of Idaho and the Department of Molecular Microbiology & Immunology, Oregon Health & Science University. He is the author or co-author of approximately 1100 peer-reviewed publications and has been awarded 70 US patents.
Catherine Clarke Fenselau is an American scientist who was the first trained mass spectrometrist on the faculty of an American medical school; she joined Johns Hopkins School of Medicine in 1968. She specializes in biomedical applications of mass spectrometry. She has been recognized as an outstanding scientist in the field of bioanalytical chemistry because of her work using mass spectrometry to study biomolecules.
Gereon Niedner-Schatteburg is a German physicist and chemist. He is professor of physical chemistry at the department of chemistry of the University of Kaiserslautern. Since 2011 he acts as director of the DFG-funded transregional collaborative research center SFB/TRR 88 3MET.de.
Kristina Håkansson is an analytical chemist known for her contribution in Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry for biomolecular identification and structural characterization. Currently, she holds the position of Professor of Chemistry at University of Michigan. Her research focuses on mass spectrometry, primarily identification and characterization of protein posttranslational modifications by complementary fragmentation techniques such as electron-capture dissociation (ECD)/negative ion ECD (niECD) and infrared multiphoton dissociation (IRMPD) at low (femtomole) levels.
Helen Jane Dyson is a British-born biophysicist and a professor of integrative structural and computational biology at the Scripps Research Institute in La Jolla, California. She was the 15th editor-in-chief of the Biophysical Journal. She was elected a Member of the National Academy of Sciences in 2022.
Melvin Barnett Comisarow is a Canadian physicist and analytical chemist who co-invented the Fourier-transform ion cyclotron resonance technique of Mass spectroscopy, together with Alan G. Marshall, at the University of British Columbia. Comisarow was born in Alberta to a Ukrainian-Canadian family, and earned his bachelor's degree at the University of Alberta, 1963, before obtaining his PhD at Case Western Reserve University, under the supervision of George Andrew Olah in 1969, and subsequently a postdoc with John D. Baldeschwieler at Stanford University. His first academic appointment was at the University of British Columbia, where he subsequently stayed until retirement.
Ron M.A. Heeren is a Dutch scientist in mass spectrometry imaging. He is currently a distinguished professor at Maastricht University and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry.
Charles Wilkins is an American chemist who is a distinguished professor of chemistry and biochemistry at the University of Arkansas and the founding director of the University of Arkansas Statewide Mass Spectrometry Facility.
Catherine E. Costello is the William Fairfield Warren distinguished professor in the department of biochemistry, Cell Biology and Genomics, and the director of the Center for Biomedical Mass Spectrometry at the Boston University School of Medicine.
Hilkka Inkeri Kenttämaa is a researcher in organic and bioorganic mass spectrometry, and the Frank Brown Endowed Distinguished Professor of Chemistry at Purdue University. She is a pioneer in distonic radical cation research and laser-induced acoustic desorption.
References
- ↑ "Home | National Academies".
- ↑ Beauchamp, Jesse Lee (1968). Ion cyclotron resonance spectroscopy (Ph.D.). Harvard University. OCLC 76979089 – via ProQuest.
- ↑ Armentrout, Peter B; Bowers, Michael T; Rodgers Mary T (2003). "A celebration of the scientific and personal contributions of Jesse (Jack) L. Beauchamp". International Journal of Mass Spectrometry. 222 (1–3): IX–XI. doi:10.1016/S1387-3806(02)01041-2.
- ↑ "Frances A. Houle" . Retrieved 10 Feb 2017.
- ↑ Jessilyn Gale (21 July 2016). "New Chair Announced for Department of Chemistry and Biochemistry" . Retrieved 10 Feb 2017.
- ↑ "Elaine M Marzluff" . Retrieved 10 Feb 2017.
