Sensodyne

Last updated
Sensodyne
Sensodyne toothpaste Iran.jpg
Sensodyne twin sachet
(in the Philippines)
Product type Toothpaste
Owner Haleon
Country United States
Introduced1961;63 years ago (1961)
Related brands Aquafresh
Biotene
MarketsWorldwide
Previous owners
Website www.sensodyne.com

Sensodyne is a brand name of toothpaste and mouthwash targeted at people with sensitive teeth. [1] Sensodyne is owned by Haleon and is marketed under the name Shumitect in Japan. [2]

Contents

Effectiveness

Sensodyne toothpastes work in different ways depending on the product's active ingredient—potassium nitrate, strontium acetate/chloride.

Potassium nitrate : The potassium ion hyperpolarizes [3] the nerve and stops it from firing. The nerve impulses are thus desensitized and there is no pain.

Strontium acetate and strontium chloride : These compounds share a similar chemical structure to calcium. Strontium based toothpastes (acetate and chloride) are therefore able to replace some of the lost calcium and block the exposed tubules in the dentinal tissue. This helps prevent the movement of the fluid within the tubules in response to a sensitivity stimulus that could otherwise cause tooth pain. [4]

Some Sensodyne products contain calcium sodium phosphosilicate CSPS (Novamin), which appears to help with tooth sensitivity. [5] [6] A randomized clinical trial published in 2015 demonstrated that dentifrices containing 5% CSPS may have the potential to mineralize and occlude the dentine in the oral environment. [7] [8] Sensodyne products sold in the United States do not contain calcium sodium phosphosilicate (Novamin). [9]

History

Sensodyne is a brand of toothpaste that was first sold by Block Drug, a Brooklyn, New York-based company established in 1907 by pharmacist Alexander Block. [1]

By 1925, manufacturing dental care products had become the company's focus. Leonard N. Block followed his father into the family business which relocated to Jersey City, New Jersey, in 1938. [10]

In 2000, Block Drug was purchased by Smith Kline Beecham P.L.C., [11] which became GlaxoSmithKline (NYSE:GSK). [12]

The toothpaste was first marketed in 1961 as a desensitising toothpaste based on a strontium chloride formulation.[ citation needed ] In 1980,[ citation needed ] Sensodyne launched a new toothpaste containing potassium nitrate, a mild local sedative. [13]

Sensodyne became a part of Haleon, a British multinational consumer healthcare corporation, in July 2022, following the establishment of Haleon as a separate entity through a corporate spin-off from GSK. [14]

Product counterfeits and recall

In 2007, GlaxoSmithKline tracked down counterfeit producers of Sensodyne after a consumer in Panama noted diethylene glycol, a poisonous ingredient commonly found in antifreeze, on the label of his toothpaste. [15]

On July 15, 2015, GlaxoSmithKline Consumer Healthcare announced a recall of certain lots of Sensodyne Repair & Protect toothpaste as well as Sensodyne Complete toothpaste due to the possible presence of wood fragments in the products. The recall also applied to the company's Biotene brand of toothpaste. The recall was a precautionary measure based on a small number of complaints, and no injuries have been reported. The recall applies to products manufactured between 2013 and September 2014, and shipped from June 2013 to April 2015. [16]

See also

Related Research Articles

<span class="mw-page-title-main">Potassium nitrate</span> Chemical compound

Potassium nitrate is a chemical compound with a sharp, salty, bitter taste and the chemical formula KNO
3
. It is an ionic salt of potassium ions K+ and nitrate ions NO3, and is therefore an alkali metal nitrate. It occurs in nature as a mineral, niter (or nitre outside the US). It is a source of nitrogen, and nitrogen was named after niter. Potassium nitrate is one of several nitrogen-containing compounds collectively referred to as saltpeter (or saltpetre outside the US).

<span class="mw-page-title-main">Toothpaste</span> Substance to clean and maintain teeth

Toothpaste is a paste or gel dentifrice used with a toothbrush to clean and maintain the aesthetics and health of teeth. Toothpaste is used to promote oral hygiene: it is an abrasive that aids in removing dental plaque and food from the teeth, assists in suppressing halitosis, and delivers active ingredients to help prevent tooth decay and gum disease (gingivitis). Owing to differences in composition and fluoride content, not all toothpastes are equally effective in maintaining oral health. The decline of tooth decay during the 20th century has been attributed to the introduction and regular use of fluoride-containing toothpastes worldwide. Large amounts of swallowed toothpaste can be poisonous. Common colors for toothpaste include white and blue.

ATC code B05Blood substitutes and perfusion solutions is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup B05 is part of the anatomical group B Blood and blood forming organs.

Tooth whitening or tooth bleaching is the process of lightening the color of human teeth. Whitening is often desirable when teeth become yellowed over time for a number of reasons, and can be achieved by changing the intrinsic or extrinsic color of the tooth enamel. The chemical degradation of the chromogens within or on the tooth is termed as bleaching.

<span class="mw-page-title-main">Strontium chloride</span> Chemical compound

Strontium chloride (SrCl2) is a salt of strontium and chloride. It is a 'typical' salt, forming neutral aqueous solutions. As with all compounds of strontium, this salt emits a bright red colour in flame, and is commonly used in fireworks to that effect. Its properties are intermediate between those for barium chloride, which is more toxic, and calcium chloride.

<span class="mw-page-title-main">Dental abrasion</span> Medical condition

Abrasion is the non-carious, mechanical wear of tooth from interaction with objects other than tooth-tooth contact. It most commonly affects the premolars and canines, usually along the cervical margins. Based on clinical surveys, studies have shown that abrasion is the most common but not the sole aetiological factor for development of non-carious cervical lesions (NCCL) and is most frequently caused by incorrect toothbrushing technique.

<span class="mw-page-title-main">Hydroxyapatite</span> Naturally occurring mineral form of calcium apatite

Hydroxyapatite is a naturally occurring mineral form of calcium apatite with the formula Ca5(PO4)3(OH), often written Ca10(PO4)6(OH)2 to denote that the crystal unit cell comprises two entities. It is the hydroxyl endmember of the complex apatite group. The OH ion can be replaced by fluoride or chloride, producing fluorapatite or chlorapatite. It crystallizes in the hexagonal crystal system. Pure hydroxyapatite powder is white. Naturally occurring apatites can, however, also have brown, yellow, or green colorations, comparable to the discolorations of dental fluorosis.

<span class="mw-page-title-main">Ringer's lactate solution</span> Fluid used for resuscitation after blood loss

Ringer's lactate solution (RL), also known as sodium lactate solution,Lactated Ringer's, and Hartmann's solution, is a mixture of sodium chloride, sodium lactate, potassium chloride, and calcium chloride in water. It is used for replacing fluids and electrolytes in those who have low blood volume or low blood pressure. It may also be used to treat metabolic acidosis and to wash the eye following a chemical burn. It is given by intravenous infusion or applied to the affected area.

<span class="mw-page-title-main">Fluoride therapy</span> Medical use of fluoride

Fluoride therapy is the use of fluoride for medical purposes. Fluoride supplements are recommended to prevent tooth decay in children older than six months in areas where the drinking water is low in fluoride. It is typically used as a liquid, pill, or paste by mouth. Fluoride has also been used to treat a number of bone diseases.

<span class="mw-page-title-main">Bioglass 45S5</span> Bioactive glass biomaterial

Bioglass 45S5 or calcium sodium phosphosilicate, is a bioactive glass specifically composed of 45 wt% SiO2, 24.5 wt% CaO, 24.5 wt% Na2O, and 6.0 wt% P2O5. Typical applications of Bioglass 45S5 include: bone grafting biomaterials, repair of periodontal defects, cranial and maxillofacial repair, wound care, blood loss control, stimulation of vascular regeneration, and nerve repair.

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<span class="mw-page-title-main">Tin(II) fluoride</span> Chemical compound

Tin(II) fluoride, commonly referred to commercially as stannous fluoride (from Latin stannum, 'tin'), is a chemical compound with the formula SnF2. It is a colourless solid used as an ingredient in toothpastes.

<span class="mw-page-title-main">Remineralisation of teeth</span>

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References

  1. 1 2 Clark, Andrew (October 7, 2000). "SmithKline to swallow Sensodyne". The Guardian. Archived from the original on October 25, 2019. Retrieved July 20, 2013.
  2. "Sensodyne | Our consumer healthcare products | Products | GlaxoSmithKline". Archived from the original on 2013-03-05. Retrieved 2013-03-17.
  3. Walsh, Margaret (Apr 15, 2014). Dental Hygiene: Theory and Practice. Elsevier Health Sciences. p. 699. ISBN   9781455745845. Archived from the original on February 27, 2024. Retrieved November 5, 2020.
  4. Hughes, N; Layer, T (2010). "Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity". Journal of Clinical Dentistry. 21 (5): 56–58. PMID   20669817.
  5. Freda, Nicolas M; Veitz-Keenan, Analia (March 2016). "Calcium sodium phosphosilicate had some benefit on dentine hypersensitivity: Question: Is calcium sodium phosphosilicate (CSPS) effective in reducing dentine hypersensitivity (DH) pain response?". Evidence-Based Dentistry. 17 (1): 12–13. doi:10.1038/sj.ebd.6401148. PMID   27012568. S2CID   24049298.
  6. Goldie, Maria (15 March 2011). "Potassium nitrate, sodium fluoride, strontium chloride, and NovaMin technologies for dentin hypersensitivity". Dentistry IQ. Archived from the original on 25 October 2019. Retrieved 21 November 2014.
  7. Jones, Siân Bodfel; Parkinson, Charles R.; Jeffery, Peter; Davies, Maria; Macdonald, Emma L.; Seong, Joon; West, Nicola X. (June 2015). "A randomised clinical trial investigating calcium sodium phosphosilicate as a dentine mineralising agent in the oral environment". Journal of Dentistry. 43 (6): 757–764. doi:10.1016/j.jdent.2014.10.005. PMID   25456613.
  8. Hall, Claire; Mason, Stephen; Cooke, Jonathan (May 2017). "Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes – a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste – for the longer-term relief of dentine hypersensitivity". Journal of Dentistry. 60: 36–43. doi: 10.1016/j.jdent.2017.02.009 . PMID   28219674.
  9. United States National Institutes of Health, National Library of Medicine, SENSODYNE REPAIR AND PROTECT – stannous fluoride paste Archived 2021-09-20 at the Wayback Machine .
  10. Saxon, Wolfgang (2005-11-12). "Leonard Block, 93, Chief of Drug Company, Is Dead". The New York Times. ISSN   0362-4331. Archived from the original on 2019-09-30. Retrieved 2019-09-30.
  11. "Company News; Smithkline to Buy Block Drug for $1.2 Billion". The New York Times. 2000-10-10. ISSN   0362-4331. Archived from the original on 2019-04-02. Retrieved 2019-09-30.
  12. "Firms Complete Merger of GlaxoSmithKline". Los Angeles Times. 2000-12-28. Archived from the original on 2019-09-30. Retrieved 2019-09-30.
  13. Ramirez, Anthony (May 13, 1990). "All About/Toothpaste; Growth Is Glacial, but the Market Is Big, and So Is the Gross". The New York Times. Archived from the original on August 26, 2014. Retrieved July 20, 2013.
  14. Khalaf, Roula (5 May 2023). "Healthy return proves worth of Haleon spin-out". Financial Times. Archived from the original on 23 November 2023. Retrieved 23 November 2023.
  15. Colgate and Sensodyne, got caught up in the sweep when counterfeiters were found to be selling toothpaste with antifreeze under their names. BOGDANICH, WALT (October 1, 2007). "The Everyman Who Exposed Tainted Toothpaste". The New York Times. Archived from the original on 16 January 2018. Retrieved 2 April 2019.
  16. "Urgent: Product Recall – Retail Level" (PDF). Smith Drug. 15 July 2015. Archived (PDF) from the original on 7 August 2015. Retrieved 21 August 2015.