Zhang Xueliang, also romanized as Chang Hsueh-liang and known later in life as Peter H. L. Chang, was a Chinese warlord who ruled Manchuria from 1928 to 1936 and the commander-in-chief of the Northeastern Army after the assassination of his father, Zhang Zuolin. A reformer who was sympathetic to nationalist ideas, he completed the official reunification of China at the end of the Warlord Era by pledging loyalty to the Nationalist government in Nanjing. He nonetheless retained Manchuria's de facto autonomy until the Empire of Japan invaded and occupied the region in 1931. He was frustrated by Chiang Kai-shek's policy of "first internal pacification, then external resistance" and helped plan and lead the 1936 Xi'an Incident. Northeastern soldiers under Zhang's command arrested Chiang to force him to negotiate a Second United Front with the Chinese Communist Party against Japan. Chiang eventually agreed, but upon his release he had Zhang arrested and sentenced to 50 years of house arrest, first in mainland China and then in Taiwan. Although never personally a communist, Zhang is regarded by the Chinese Communist Party and the People's Republic of China as a patriotic hero for his role in ending the encirclement campaigns and beginning the war of resistance against Japan.
Multiple sclerosis (MS) is an autoimmune disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. Specific symptoms can include double vision, vision loss, eye pain, muscle weakness, and loss of sensation or coordination. MS takes several forms, with new symptoms either occurring in isolated attacks or building up over time. In the relapsing forms of MS, between attacks, symptoms may disappear completely, although some permanent neurological problems often remain, especially as the disease advances. In the progressive forms of MS, bodily function slowly deteriorates and disability worsens once symptoms manifest and will steadily continue to do so if the disease is left untreated.
Dihydrexidine (DAR-0100) is a moderately selective full agonist at the dopamine D1 and D5 receptors. It has approximately 10-fold selectivity for D1 and D5 over the D2 receptor. Although dihydrexidine has some affinity for the D2 receptor, it has functionally selective (highly biased) D2 signaling, thereby explaining why it lacks D2 agonist behavioral qualities.
Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.
60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.
Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.
Brevican core protein is a protein that in humans is encoded by the BCAN gene. Brevican is a member of the lectican protein family.
Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.
AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene.
Zinc finger protein 451 is a novel nuclear protein that in humans is encoded by the ZNF451 gene.
LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.
The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. In complex with the interleukin-12 receptor β1 subunit (IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23). The IL23R mRNA is 2.8 kilobases in length and includes 12 exons. The translated protein contains 629 amino acids; it is a type I penetrating protein and includes a signal peptide, an N-terminal fibronectin III-like domain and an intracellular part that contains three potential tyrosine phosphorylation domains. There are 24 IL23R splice variants in mitogen-activated lymphocytes. IL23R includes some single-nucleotide polymorphisms in the region encoding the domain that binds IL-23, which may lead to differences between people in Th17 activation. There is also a variant of IL-23R that consists of just the extracellular part and is known as soluble IL-23R. This form can compete with the membrane-bound form to bind IL-23, modulating the Th17 immune response and regulation of inflammation and immune function.
Styphnolobium japonicum, the Japanese pagoda tree is a species of deciduous tree in the subfamily Faboideae of the pea family Fabaceae.
Capillary electrophoresis–mass spectrometry (CE–MS) is an analytical chemistry technique formed by the combination of the liquid separation process of capillary electrophoresis with mass spectrometry. CE–MS combines advantages of both CE and MS to provide high separation efficiency and molecular mass information in a single analysis. It has high resolving power and sensitivity, requires minimal volume and can analyze at high speed. Ions are typically formed by electrospray ionization, but they can also be formed by matrix-assisted laser desorption/ionization or other ionization techniques. It has applications in basic research in proteomics and quantitative analysis of biomolecules as well as in clinical medicine. Since its introduction in 1987, new developments and applications have made CE-MS a powerful separation and identification technique. Use of CE–MS has increased for protein and peptides analysis and other biomolecules. However, the development of online CE–MS is not without challenges. Understanding of CE, the interface setup, ionization technique and mass detection system is important to tackle problems while coupling capillary electrophoresis to mass spectrometry.
Amentoflavone is a biflavonoid constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Biophytum sensitivum, Selaginella tamariscina, Hypericum perforatum and Xerophyta plicata.
L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.
The Jiashi earthquakes were a series of earthquakes from 1997 to 2003, with several earthquakes larger than 6 occurring between January and April, 1997. Two strong earthquakes with magnitudes Ms 6.4 and 6.3 occurred on January 21, 1997, at 09:47 and 09:48 local time, respectively, in Jiashi County of Xinjiang Autonomous Region, NW China. The earthquakes occurred on a major strike-slip fault beneath the Tarim Basin. The fault has no surface expression and prior to the earthquake was unknown. At least 12 people were killed and 40 injured in the earthquakes of January 21. Another earthquake on March 1, 1997, at 14:04 local time with magnitude Ms 6.0 killed another person. On April 6, 11 and 16, other four earthquakes with magnitudes Ms 6.3, 6.4, 6.6 and 6.3 killed 8 people. Several predictions were made in this earthquake series. Some of the predictions were not fulfilled, while some preceded the predicted earthquake from 2.5 hours to 4 days. The April 11 earthquake occurred 30 minutes after a prediction was made. Rebiya Kadeer wrote that her career was significantly affected by the earthquakes, which were "one of the worst natural disasters that had occurred in the Uyghur nation in recent memory." One hundred villages and one thousand homes were leveled. Kadeer organized donations and aid for the area.
Cephidae is a family of stem sawflies in the order Hymenoptera. There are about 27 genera and more than 160 described species in Cephidae.
Thynnoidea is a superfamily of hymenopterans in the order Hymenoptera. There are 2 families and hundreds of described species in Thynnoidea.
Tiphioidea is a suggested superfamily of stinging wasps in the order Hymenoptera. There are three families in Tiphioidea, Bradynobaenidae, Tiphiidae, and Sierolomorphidae.
