Sphingomyelin deacylase

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Sphingomyelin deacylase
Identifiers
EC no. 3.5.1.109
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Sphingomyelin deacylase (EC 3.5.1.109, SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase) is an enzyme with systematic name N-acyl-sphingosylphosphorylcholine amidohydrolase. [1] [2] [3] This enzyme catalyses the following chemical reaction

(1) an N-acyl-sphingosylphosphorylcholine + H2O a fatty acid + sphingosylphosphorylcholine;;
(2) a D-glucosyl-N-acylsphingosine + H2O a fatty acid + D-glucosyl-sphingosine

The enzyme is involved in the sphingolipid metabolism in the epidermis.

Related Research Articles

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<span class="mw-page-title-main">Stearoyl-CoA 9-desaturase</span> Class of enzymes

Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. In humans, the enzyme is encoded by the SCD gene.

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<span class="mw-page-title-main">Glucosylceramidase</span>

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Sapienic acid is a fatty acid that is a major component of human sebum. Unique to humans, it takes its scientific name from the root sapiens. The equivalent fatty acid in mouse sebum is palmitoleic acid. Sapienic acid salts, esters, anion, and conjugate base are known as sapienates.

Delta11-fatty-acid desaturase (EC 1.14.19.5, Delta11 desaturase, fatty acid Delta11-desaturase, TpDESN, Cro-PG, Delta11 fatty acid desaturase, Z/E11-desaturase, Delta11-palmitoyl-CoA desaturase) is an enzyme with systematic name acyl-CoA,hydrogen donor:oxygen Delta11-oxidoreductase. This enzyme catalyses the following chemical reaction

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3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase (EC 4.2.1.60, D-3-hydroxydecanoyl-[acyl-carrier protein] dehydratase, 3-hydroxydecanoyl-acyl carrier protein dehydrase, 3-hydroxydecanoyl-acyl carrier protein dehydratase, β-hydroxydecanoyl thioester dehydrase, β-hydroxydecanoate dehydrase, beta-hydroxydecanoyl thiol ester dehydrase, FabA, β-hydroxyacyl-acyl carrier protein dehydratase, HDDase, β-hydroxyacyl-ACP dehydrase, (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase) is an enzyme with systematic name (3R)-3-hydroxydecanoyl-(acyl-carrier protein) hydro-lyase. This enzyme catalyses the following chemical reaction

References

  1. ↑ Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (September 2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis". The Journal of Investigative Dermatology. 115 (3): 406–13. doi: 10.1046/j.1523-1747.2000.00072.x . PMID   10951276.
  2. ↑ Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G (September 2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide". The Biochemical Journal. 350 Pt 3: 747–56. doi:10.1042/0264-6021:3500747. PMC   1221306 . PMID   10970788.
  3. ↑ Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G (March 2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis". Laboratory Investigation; A Journal of Technical Methods and Pathology. 83 (3): 397–408. doi: 10.1097/01.lab.0000059931.66821.92 . PMID   12649340.
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