Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by intravenous injection. There is also an albumin-bound formulation.
Taxus is a genus of coniferous trees or shrubs known as yews in the family Taxaceae. Yews occur around the globe in temperate zones of the northern hemisphere, northernmost in Norway and southernmost in the South Celebes. Some populations exist in tropical highlands.
Taxaceae, commonly called the yew family, is a coniferous family which includes six extant and two extinct genera, and about 30 species of plants, or in older interpretations three genera and 7 to 12 species.
Prumnopitys taxifolia, the mataī or black pine, is an endemic New Zealand coniferous tree that grows on the North Island and South Island. It also occurs on Stewart Island/Rakiura but is uncommon there.
Taxus baccata is a species of evergreen tree in the family Taxaceae, native to Western Europe, Central Europe and Southern Europe, Northwest Africa, northern Iran, and Southwest Asia. It is the tree originally known as yew, though with other related trees becoming known, it may now be known as common yew, English yew, or European yew. It is primarily grown as an ornamental. Most parts of the plant are poisonous, with toxins that can be absorbed through inhalation and through the skin; consumption of even a small amount of the foliage can result in death.
Austrotaxus spicata, the New Caledonia yew or southern yew, is a species of yew, the sole species in the genus Austrotaxus. It is related to the other yews in the genera Taxus and Pseudotaxus.
Taxus cuspidata, the Japanese yew or spreading yew, is a member of the genus Taxus, native to Japan, Korea, northeast China and the extreme southeast of Russia.
Taxus brevifolia, the Pacific yew or western yew, is a species of tree in the yew family Taxaceae native to the Pacific Northwest of North America. It is a small evergreen conifer, thriving in moisture and otherwise tending to take the form of a shrub.
Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
Taxus canadensis, the Canada yew or Canadian yew, is a conifer native to central and eastern North America, thriving in swampy woods, ravines, riverbanks and on lake shores. Locally called simply "yew", this species is also referred to as American yew or ground-hemlock.
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew. Not only is the synthetic reproduction of the compound itself of great commercial and scientific importance, but it also opens the way to paclitaxel derivatives not found in nature but with greater potential.
Taxus wallichiana, the Himalayan yew, is a species of yew, native to the Himalaya and parts of south-east Asia. The species has a variety of uses in traditional medicine. It is currently classified as endangered by the IUCN.
Taxus chinensis is a species of yew. It is commonly called the Chinese yew, though this term also refers to Taxus celebica or Taxus sumatrana.
Taxus floridana, the Florida yew, is a species of yew, endemic to a small area of under 10 km² on the eastern side of the Apalachicola River in mesophytic forests of northern Florida at altitudes of 15–40 m. It is listed as critically endangered. It is protected in reserves at the Torreya State Park and at the Nature Conservancy's Apalachicola Bluffs and Ravines Preserve, and has legal protection under the United States and Florida Endangered Species laws.
The enzyme taxadiene synthase catalyzes the chemical reaction
Baccatin III is an isolate from the yew tree. Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol).
Taxine alkaloids, which are often named under the collective title of taxines, are the toxic chemicals that can be isolated from the yew tree. The amount of taxine alkaloids depends on the species of yew, with Taxus baccata and Taxus cuspidata containing the most. The major taxine alkaloids are taxine A and taxine B although there are at least 10 different alkaloids. Until 1956, it was believed that all the taxine alkaloids were one single compound named taxine.
Taxus × media, sometimes known simply as Taxus media, is a conifer created by the hybridization of English yew Taxus baccata and Japanese yew Taxus cuspidata. This hybridization is thought to have been performed by the Massachusetts-based horticulturalist T.D. Hatfield in the early 1900s.
Taxus mairei, Maire's yew, is a species of conifer in the yew family Taxaceae, native to Nepal, Assam, central and southern China, Hainan, Taiwan and Vietnam. It is extensively harvested for its paclitaxel (taxol) content in China.
Pestalotiopsis pauciseta is an endophytic fungi isolated from the leaves of several medicinal plants in tropical climates. Pestalotiopsis pauciseta is known for its role in medical mycology, having the ability to produce a chemical compound called paclitaxel (taxol). Taxol is the first billion-dollar anticancer drug, notably the fungal-taxol produced by Pestalotiopsis pauciseta was determined to be comparable to standard taxol.
