Tryptophan 2'-dioxygenase

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tryptophan 2'-dioxygenase
Identifiers
EC no. 1.13.99.3
CAS no. 64295-81-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, a tryptophan 2'-dioxygenase (EC 1.13.99.3) is an enzyme that catalyzes the chemical reaction

Contents

Tryptophan 2'-dioxygenase.svg
L-tryptophan + O
2
+ H+
(indol-3-yl)glycolaldehyde + CO
2
+ NH+
4

Thus, the 3 substrates of this enzyme are L-tryptophan, O
2
and H+
, whereas its 3 products are (indol-3-yl)glycolaldehyde, CO
2
, and NH+
4
.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O miscellaneous.

Nomenclature

The systematic name of this enzyme class is L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving). Other names in common use include indole-3-alkane alpha-hydroxylase, tryptophan side-chain alpha,beta-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan alpha-hydroxylase, tryptophan side chain oxidase type I, TSO I, TSO II, and tryptophan side chain oxidase.

Biological role

This enzyme participates in tryptophan metabolism. It employs one cofactor, heme.

References