Urodilatin

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Urodilatin
Urodilatin - Compound Summary (CID 16133394).svg
Urodilatin CDDANP-95-126.gif
Identifiers
3D model (JSmol)
ChemSpider
KEGG
MeSH Urodilatin
PubChem CID
UNII
  • InChI=1S/C145H234N52O44S3/c1-11-72(6)112-137(238)171-60-106(208)172-73(7)113(214)177-86(40-41-103(146)205)122(223)190-95(63-198)116(217)170-61-108(210)175-88(51-70(2)3)114(215)169-62-109(211)176-100(133(234)187-92(56-104(147)206)127(228)193-97(65-200)130(231)186-91(54-77-27-16-13-17-28-77)126(227)180-82(31-20-45-163-142(153)154)119(220)189-94(139(240)241)55-78-36-38-79(204)39-37-78)68-243-244-69-101(134(235)185-90(53-76-25-14-12-15-26-76)115(216)168-58-105(207)167-59-107(209)174-80(29-18-43-161-140(149)150)117(218)182-87(42-50-242-10)123(224)188-93(57-110(212)213)128(229)181-85(124(225)196-112)34-23-48-166-145(159)160)195-132(233)99(67-202)194-131(232)98(66-201)192-120(221)83(32-21-46-164-143(155)156)178-118(219)81(30-19-44-162-141(151)152)179-125(226)89(52-71(4)5)184-129(230)96(64-199)191-121(222)84(33-22-47-165-144(157)158)183-135(236)102-35-24-49-197(102)138(239)74(8)173-136(237)111(148)75(9)203/h12-17,25-28,36-39,70-75,80-102,111-112,198-204H,11,18-24,29-35,40-69,148H2,1-10H3,(H2,146,205)(H2,147,206)(H,167,207)(H,168,216)(H,169,215)(H,170,217)(H,171,238)(H,172,208)(H,173,237)(H,174,209)(H,175,210)(H,176,211)(H,177,214)(H,178,219)(H,179,226)(H,180,227)(H,181,229)(H,182,218)(H,183,236)(H,184,230)(H,185,235)(H,186,231)(H,187,234)(H,188,224)(H,189,220)(H,190,223)(H,191,222)(H,192,221)(H,193,228)(H,194,232)(H,195,233)(H,196,225)(H,212,213)(H,240,241)(H4,149,150,161)(H4,151,152,162)(H4,153,154,163)(H4,155,156,164)(H4,157,158,165)(H4,159,160,166)/t72-,73-,74-,75+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-/m0/s1
  • CCC(C)C1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)NC(CSSCC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)CC(=O)O)CCSC)CCCNC(=N)N)Cc2ccccc2)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C(C(C)O)N)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(Cc4ccccc4)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc5ccc(cc5)O)C(=O)O)CC(C)C)CO)CCC(=O)N)C
Properties
C145H234N52O44S3
Molar mass 3505.926
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Urodilatin (URO) is a hormone that causes natriuresis by increasing renal blood flow. It is secreted in response to increased mean arterial pressure and increased blood volume from the cells of the distal tubule and collecting duct. It is important in oliguric patients (such as those with acute kidney injury and chronic kidney failure) as it lowers serum creatinine and increases urine output.

Contents

Interactions

Atrial natriuretic peptide (ANP; CDD/ANP-99-126; NPPA-124-151, 28 residues) is a hormone system of clinical importance. It is produced in the heart and excreted into the circulation via exocytosis. The endocrine heart is composed of specific myoendocrine cells that synthesize and secrete the natriuretic peptide hormones, which exhibit diuretic and vasorelaxant properties. [1] Urodilatin (CDD/ANP-95-126; NPPA-120-151, 32 residues) is a homologue natriuretic peptide that differs from CDD/ANP-99-126 by a four-residue extension at the N-terminal end, produced by the kidney as part of a paracrine system regulating water and sodium reabsorption. [2] [3] It is secreted into the urine. [4] [5]

Effects

Research efforts since the early 1980s have studied their effects on electrolyte homeostasis. [6] Natriuretic peptides bind to the atrial natriuretic peptide receptors, resulting in a cGMP-dependent signal transduction, which induces diuresis and natriuresis. [7]

The potency of urodilatin equals or exceeds that of ANP. [8] Atriopeptin is only of trivial importance in the regulation of sodium excretion during normal living conditions, unlike urodilatin which the kidney produces to control itself. [9]

Metabolism

Neutral endopeptidase-24.11 (NEP) plays a physiological role in degrading the natriuretic peptides. [10]

Endogenous urodilatin is little affected by renal enzymes that inactivate ANP such as NEP, as the kidney elutes with urodilatin rather than with ANP. [11]

The degradation rates of (125I)-urodilatin and [125I]-ANP by pure recombinant NEP (rNEP) were compared. Phosphoramidon, a potent inhibitor of NEP, completely protected both peptides from metabolism by rNEP. [12]

Drug development

When administered intravenously, urodilatin induces strong diuresis and natriuresis with tolerable hemodynamic side effects. [4] As a consequence, urodilatin is involved in drug development along with the proANP (CDD/ANP-1-126) [1] and mature ANP (CDD/ANP-99-126). [3]

References

  1. 1 2 Meyer M, Stief CG, Becker AJ, Truss MC, Taher A, Jonas U, Forssmann WG (June 1988). "The renal paracrine peptide system--possible urologic implications of urodilatin". World J Urol. 14 (2): 249–54. doi:10.1007/BF00183118. ISSN   0724-4983. PMID   8986039. S2CID   37318078.
  2. ↑ Gagelmann M, Hock D, Forssmann WG (June 1988). "Urodilatin (CDD/ANP-95-126) is not biologically inactivated by a peptidase from dog kidney cortex membranes in contrast to atrial natriuretic peptide/cardiodilatin (alpha-hANP/CDD-99-126)". FEBS Lett. 233 (2): 249–54. doi:10.1016/0014-5793(88)80436-8. PMID   2968281. S2CID   28895937.
  3. 1 2 Forssmann WG, Richter R, Meyer M (October 1998). "The endocrine heart and natriuretic peptides: histochemistry, cell biology, and functional aspects of the renal urodilatin system". Histochem Cell Biol. 110 (4): 335–57. doi:10.1007/s004180050295. PMID   9792413. S2CID   9324731.
  4. 1 2 Kuse ER, Meyer M, Constantin R, Oldhafer K, Schlitt HJ, Schulz-Knappe P, Uberbacher HJ, Pichlmayr R, Forssmann WG (April 1996). "[Urodilatin (INN: ularitide). A new peptide in the treatment of acute kidney failure following liver transplantation]". Der Anaesthesist. 45 (4): 351–8. doi:10.1007/s001010050271. PMID   8702053. S2CID   34683941.
  5. ↑ Forssmann W, Meyer M, Forssmann K (August 2001). "The renal urodilatin system: clinical implications". Cardiovasc. Res. 51 (3): 450–62. doi: 10.1016/S0008-6363(01)00331-5 . PMID   11476735.
  6. ↑ Meyer M, Schulz-Knappe P, Kuse ER, Hummel M, Hetzer R, Pichlmayr R, Forssmann WG (February 1995). "[Urodilatin. Use of a new peptide in intensive care]". Der Anaesthesist. 44 (2): 81–91. doi:10.1007/s001010050135. PMID   7702187. S2CID   5706848.
  7. ↑ Meyer M, Richter R, Forssmann WG (October 1998). "Urodilatin, a natriuretic peptide with clinical implications". Eur J Med Res. 3 (1–2): 103–110. PMID   9512977.
  8. ↑ Goetz KL. (December 1991). "Renal natriuretic peptide (urodilatin?) and atriopeptin: evolving concepts". Am J Physiol. 261 (6): 921–32. doi:10.1152/ajprenal.1991.261.6.F921. PMID   1836308.
  9. ↑ Goetz KL. (December 1993). "Is urodilatin (rather than atriopeptin) the primary natriuretic peptide of the ANP family?". J Cardiovasc Pharmacol. 22 (6): 911–913. doi: 10.1097/00005344-199322002-00027 . PMID   7508039.
  10. ↑ Kenny AJ, Bourne A, Ingram J (April 1998). "Hydrolysis of human and pig brain natriuretic peptides, urodilatin, C-type natriuretic peptide and some C-receptor ligands by endopeptidase-24.11". Biochem. J. 1 (291): 83–8. doi:10.1042/bj2910083. PMC   1132484 . PMID   8097089.
  11. ↑ Goetz K, Drummer C, Zhu JL, Leadley R, Fiedler F, Gerzer R (December 1990). "Evidence that urodilatin, rather than ANP, regulates renal sodium excretion". J Am Soc Nephrol. 1 (6): 867–74. doi: 10.1681/ASN.V16867 . ISSN   1533-3450. PMID   1966524.
  12. ↑ Abassi ZA, Golomb E, Agbaria R, Roller PP, Tate J, Keiser HR (September 1994). "Hydrolysis of iodine labelled urodilatin and ANP by recombinant neutral endopeptidase EC. 3.4.24.11". Br J Pharmacol. 113 (1): 204–208. doi:10.1111/j.1476-5381.1994.tb16194.x. PMC   1510039 . PMID   7812611.
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